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Combination drug
Tetrabamate (Atrium , G Tril , Sevrium ) is a combination drug formulation of febarbamate , difebarbamate , and phenobarbital which was marketed in France and Spain and was used to treat anxiety and alcohol withdrawal -associated muscle tremors , agitation , and depression .[ 1] [ 2] [ 3] [ 4] discontinued on April 4, 1997, after over 30 years of use due to reports of hepatitis and acute liver failure .[ 3] [ 4] [ 5] [ 6] [clarification needed [ 6]
^ Index nominum 2000: international drug directory ISBN 978-3-88763-075-1 . Retrieved 26 November 2011 .^ Chitturi S, Farrell GC (19 October 2011). "Drug-Induced Liver Disease" . In Schiff ER, Maddrey WC, Sorrell MF (eds.). Schiff's Diseases of the Liver . John Wiley and Sons. pp. 703–783. doi :10.1002/9781119950509.ch27 . ISBN 978-1-119-95048-6 . Retrieved 26 November 2011 . ^ a b Binder D, Jost R, Flury R, Salomon F (May 1995). "[Acute liver failure following tetrabamate]". Schweizerische Medizinische Wochenschrift (in German). 125 (19): 965–969. PMID 7761807 . ^ a b Consolidated list of products whose consumption and/or sale have been banned, withdrawn, severely restricted or not approved by governments ISBN 978-92-1-130230-1 . Retrieved 26 November 2011 .[permanent dead link ] ^ Horsmans Y, Lannes D, Pessayre D, Larrey D (December 1994). "Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate". Journal of Hepatology . 21 (6): 1075–1079. doi :10.1016/s0168-8278(05)80620-8 . PMID 7699230 . ^ a b "Severe hepatitis due to Atrium". Prescrire International . 10 (55): 150. October 2001. PMID 11824432 .
Alcohols Barbiturates Benzodiazepines Carbamates Flavonoids Imidazoles Kava constituentsMonoureides Neuroactive steroids Nonbenzodiazepines Phenols Piperidinediones Pyrazolopyridines Quinazolinones Volatiles /gases Others/unsorted
3-Hydroxybutanal α-EMTBL AA-29504 Alogabat Avermectins (e.g., ivermectin )Bromide compounds (e.g., lithium bromide , potassium bromide , sodium bromide )Carbamazepine Chloralose Chlormezanone Clomethiazole Darigabat DEABL Deuterated etifoxine Dihydroergolines (e.g., dihydroergocryptine , dihydroergosine , dihydroergotamine , ergoloid (dihydroergotoxine) )DS2 Efavirenz Etazepine Etifoxine Fenamates (e.g., flufenamic acid , mefenamic acid , niflumic acid , tolfenamic acid )Fluoxetine Flupirtine Hopantenic acid KRM-II-81 Lanthanum Lavender oil Lignans (e.g., 4-O-methylhonokiol , honokiol , magnolol , obovatol )Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine) Safranal Seproxetine Stiripentol Sulfonylalkanes (e.g., sulfonmethane (sulfonal) , tetronal , trional )Terpenoids (e.g., borneol )Topiramate Valerian constituents (e.g., isovaleric acid , isovaleramide , valerenic acid , valerenol )
