User:Ride or die baby/sandbox

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Here are some sources for the calcium channel research and editing:

^[1]"The role of T-type calcium channels in epilepsy and pain."
^[2]"The role of calcium channel blockers in the treatment of essential hypertension." https://www.ncbi.nlm.nih.gov/pubmed/1992952
^[3]"PKD2 cation channel is required for directional sperm movement and male fertility." https://www.ncbi.nlm.nih.gov/pubmed/14680633
^[4]"Function and dysfunction of two-pore channels." https://www.ncbi.nlm.nih.gov/pubmed/26152696

Plans for editing page:

Beef up table by adding information about two-pore channels and cation channels of sperm and cite good sources

^[5]Two-pore channel: Gated by: Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Gene: TPCN1, TPCN2 Location: endosomal/lysosomal membranes Function: NAADP-activated calcium channel across endosomal/lysosomal membranes (http://www.uniprot.org/uniprot/Q9ULQ1)

^[6]Cation channels of sperm: Gated by: Calcium Gene: PKD2 family Location: sperm (specifically flagella) Function: non-selective calcium-activated cation channel directing sperm in female reproductive tract ("PKD2 cation channel is required for directional sperm movement and male fertility." https://www.ncbi.nlm.nih.gov/pubmed/14680633) *this information and the information on two-pore channels will be added into the table listing different types of calcium channels. This will help round out the information presented in the article and make it more comprehensive.

Beef up pharmacology section by expounding on mechanism of epilepsy and hypertension treatment and cite good sources

^[7]Hypertension: in most areas of the body, depolarization is mediated by sodium influx into a cell; changing the calcium permeability has little effect on action potentials. However, in many smooth muscle tissues, depolarization is mediated primarily by calcium influx into the cell. Calcium channel blockers selectively inhibit these action potentials in smooth muscle which leads to dilation of blood vessels; this in turn corrects hypertension.

"Pharmacology and mechanisms of action of calcium-channel blockers." https://www.ncbi.nlm.nih.gov/pubmed/3540226

^[8]Epilepsy: increased calcium conductance in the neurons leads to increased depolarization and excitability. This leads to a greater predisposition to epileptic episodes. Calcium channel blockers reduce the neuronal calcium conductance and reduce the likelihood of experiencing epileptic attacks.

"Role of voltage-gated calcium channels in epilepsy." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312315/ *This info on hypertension and epilepsy will replace the final paragraph in the article and give it a little more depth.

Peer Review by Jarett Anderson

I think this is a really good start. I would only suggest next to make an outline of which paragraphs you want to incorporate your research into. Don't forget to find one image or figure to add, and I've found that if you click the "cite" button above, it will cite your sources next to any word you choose. Be sure to use that once you start to implement what you've researched and inserted it into the original source. Great job, just organize it now!

-Jarett

Thanks for the feedback Jarett! This is really helpful, I have already added the citations like you showed me how to do. I will get on looking for a good figure to add. And I'll be a little more clear as to where I will be adding this new information.

2nd peer review: The sources look great! Based on your presentation I think there is some room to talk about the difference between L-type and T-type calcium channels and to possibly explain the difference between the voltage-gated calcium channel vs the ligand gated calcium channel.

Excited to see the final product!

Jarett

Thanks again for the timely feedback my man! I appreciate it. I understand that the current page doesn't go into much detail about those differences you mentioned, and I think it is because they are more thoroughly filled out in their own Wikipedia pages. I feel like it would be somewhat redundant to add more than the brief descriptions that are already there. But if there is something specific you feel should be added regarding the differences, let me know. I'm open to suggestions.

Sources

^ Nelson, M. T.; Todorovic, S. M.; Perez-Reyes, E. (2006). "The role of T-type calcium channels in epilepsy and pain". Current Pharmaceutical Design. 12 (18): 2189–2197. ISSN 1381-6128. PMID 16787249.
^ Cummings, D. M.; Amadio, P.; Nelson, L.; Fitzgerald, J. M. (February 1991). "The role of calcium channel blockers in the treatment of essential hypertension". Archives of Internal Medicine. 151 (2): 250–259. ISSN 0003-9926. PMID 1992952.
^ Gao, Zhiqian; Ruden, Douglas M.; Lu, Xiangyi (2003-12-16). "PKD2 cation channel is required for directional sperm movement and male fertility". Current biology: CB. 13 (24): 2175–2178. ISSN 0960-9822. PMID 14680633.
^ Patel, Sandip (2015-07-07). "Function and dysfunction of two-pore channels". Science Signaling. 8 (384): re7. doi:10.1126/scisignal.aab3314. ISSN 1937-9145. PMID 26152696.
^ "TPCN1 - Two pore calcium channel protein 1 - Homo sapiens (Human) - TPCN1 gene & protein". www.uniprot.org. Retrieved 2017-11-16.
^ Gao, Zhiqian; Ruden, Douglas M.; Lu, Xiangyi (2003-12-16). "PKD2 cation channel is required for directional sperm movement and male fertility". Current biology: CB. 13 (24): 2175–2178. ISSN 0960-9822. PMID 14680633.
^ Katz, A. M. (September 1986). "Pharmacology and mechanisms of action of calcium-channel blockers". Journal of Clinical Hypertension. 2 (3 Suppl): 28S–37S. ISSN 0748-450X. PMID 3540226.
^ Zamponi, Gerald W.; Lory, Philippe; Perez-Reyes, Edward (2010-7). "Role of voltage-gated calcium channels in epilepsy". Pflugers Archiv. 460 (2): 395–403. doi:10.1007/s00424-009-0772-x. ISSN 0031-6768. PMC 3312315. PMID 20091047. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link)

[1] Nelson, M. T.; Todorovic, S. M.; Perez-Reyes, E. (2006). "The role of T-type calcium channels in epilepsy and pain". Current Pharmaceutical Design. 12 (18): 2189–2197. ISSN 1381-6128. PMID 16787249.

[2] Cummings, D. M.; Amadio, P.; Nelson, L.; Fitzgerald, J. M. (February 1991). "The role of calcium channel blockers in the treatment of essential hypertension". Archives of Internal Medicine. 151 (2): 250–259. ISSN 0003-9926. PMID 1992952.

[3] Gao, Zhiqian; Ruden, Douglas M.; Lu, Xiangyi (2003-12-16). "PKD2 cation channel is required for directional sperm movement and male fertility". Current biology: CB. 13 (24): 2175–2178. ISSN 0960-9822. PMID 14680633.

[4] Patel, Sandip (2015-07-07). "Function and dysfunction of two-pore channels". Science Signaling. 8 (384): re7. doi:10.1126/scisignal.aab3314. ISSN 1937-9145. PMID 26152696.

[5] "TPCN1 - Two pore calcium channel protein 1 - Homo sapiens (Human) - TPCN1 gene & protein". www.uniprot.org. Retrieved 2017-11-16.

[6] Gao, Zhiqian; Ruden, Douglas M.; Lu, Xiangyi (2003-12-16). "PKD2 cation channel is required for directional sperm movement and male fertility". Current biology: CB. 13 (24): 2175–2178. ISSN 0960-9822. PMID 14680633.

[7] Katz, A. M. (September 1986). "Pharmacology and mechanisms of action of calcium-channel blockers". Journal of Clinical Hypertension. 2 (3 Suppl): 28S–37S. ISSN 0748-450X. PMID 3540226.

[8] Zamponi, Gerald W.; Lory, Philippe; Perez-Reyes, Edward (2010-7). "Role of voltage-gated calcium channels in epilepsy". Pflugers Archiv. 460 (2): 395–403. doi:10.1007/s00424-009-0772-x. ISSN 0031-6768. PMC 3312315. PMID 20091047. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link)

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