Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 01:54, 10 November 2007 (UTC)
[edit]Proteins without matches (17)
[edit]Proteins with a High Potential Match (8)
[edit]Manual Inspection (Page not found) (19)
[edit]
Protein Status Grid - Date: 01:54, 10 November 2007 (UTC)
[edit]Vebose Log - Date: 01:54, 10 November 2007 (UTC)
[edit]- INFO: Beginning work on BTG2... {November 9, 2007 5:41:38 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:42:37 PM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = BTG family, member 2
| HGNCid = 1131
| Symbol = BTG2
| AltSymbols =; PC3; MGC126063; MGC126064; TIS21
| OMIM = 601597
| ECnumber =
| Homologene = 31406
| MGIid = 108384
| GeneAtlas_image1 = PBB_GE_BTG2_201236_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BTG2_201235_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006479 |text = protein amino acid methylation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009952 |text = anterior/posterior pattern formation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7832
| Hs_Ensembl = ENSG00000159388
| Hs_RefseqProtein = NP_006754
| Hs_RefseqmRNA = NM_006763
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 201541242
| Hs_GenLoc_end = 201545353
| Hs_Uniprot = P78543
| Mm_EntrezGene = 12227
| Mm_Ensembl = ENSMUSG00000020423
| Mm_RefseqmRNA = NM_007570
| Mm_RefseqProtein = NP_031596
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 135891276
| Mm_GenLoc_end = 135895566
| Mm_Uniprot = Q3TF68
}}
}}
'''BTG family, member 2''', also known as '''BTG2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle.<ref>{{cite web | title = Entrez Gene: BTG2 BTG family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7832| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Puisieux A, Magaud JP |title=[Mechanisms of BTG2 activity, a transcriptional target of p53: evidences and hypothesis.] |journal=Bulletin du cancer |volume=86 |issue= 4 |pages= 358-64 |year= 1999 |pmid= 10341341 |doi= }}
*{{cite journal | author=Tirone F |title=The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair? |journal=J. Cell. Physiol. |volume=187 |issue= 2 |pages= 155-65 |year= 2001 |pmid= 11267995 |doi= 10.1002/jcp.1062 }}
*{{cite journal | author=Matsuda S, Rouault J, Magaud J, Berthet C |title=In search of a function for the TIS21/PC3/BTG1/TOB family. |journal=FEBS Lett. |volume=497 |issue= 2-3 |pages= 67-72 |year= 2001 |pmid= 11377414 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on C1S... {November 9, 2007 5:20:31 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein C1S image.jpg {November 9, 2007 5:21:03 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 5:21:12 PM PST}
- CREATED: Created new protein page: C1S {November 9, 2007 5:21:23 PM PST}
- INFO: Beginning work on CALCR... {November 9, 2007 5:21:23 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:22:21 PM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Calcitonin receptor
| HGNCid = 1440
| Symbol = CALCR
| AltSymbols =; CRT; CTR; CTR1
| OMIM = 114131
| ECnumber =
| Homologene = 1320
| MGIid = 101950
| GeneAtlas_image1 = PBB_GE_CALCR_207886_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CALCR_207887_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0004948 |text = calcitonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0007202 |text = phospholipase C activation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 799
| Hs_Ensembl = ENSG00000004948
| Hs_RefseqProtein = NP_001733
| Hs_RefseqmRNA = NM_001742
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 92891735
| Hs_GenLoc_end = 93041686
| Hs_Uniprot = P30988
| Mm_EntrezGene = 12311
| Mm_Ensembl = ENSMUSG00000023964
| Mm_RefseqmRNA = NM_001042725
| Mm_RefseqProtein = NP_001036190
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 3637395
| Mm_GenLoc_end = 3672973
| Mm_Uniprot = Q790U4
}}
}}
'''Calcitonin receptor''', also known as '''CALCR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pondel M |title=Calcitonin and calcitonin receptors: bone and beyond. |journal=International journal of experimental pathology |volume=81 |issue= 6 |pages= 405-22 |year= 2001 |pmid= 11298188 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CALD1... {November 9, 2007 5:22:21 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:24:01 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Caldesmon 1
| HGNCid = 1441
| Symbol = CALD1
| AltSymbols =; CDM; H-CAD; L-CAD; MGC21352; NAG22
| OMIM = 114213
| ECnumber =
| Homologene = 69531
| MGIid =
| GeneAtlas_image1 = PBB_GE_CALD1_201616_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CALD1_201615_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CALD1_201617_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005523 |text = tropomyosin binding}} {{GNF_GO|id=GO:0017022 |text = myosin binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0030478 |text = actin cap}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 800
| Hs_Ensembl = ENSG00000122786
| Hs_RefseqProtein = NP_004333
| Hs_RefseqmRNA = NM_004342
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 134114711
| Hs_GenLoc_end = 134306010
| Hs_Uniprot = Q05682
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Caldesmon 1''', also known as '''CALD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.<ref>{{cite web | title = Entrez Gene: CALD1 caldesmon 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=800| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Huber PA |title=Caldesmon. |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 8-9 |pages= 1047-51 |year= 1998 |pmid= 9415999 |doi= }}
*{{cite journal | author=Gusev NB |title=Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation. |journal=Biochemistry Mosc. |volume=66 |issue= 10 |pages= 1112-21 |year= 2002 |pmid= 11736632 |doi= }}
*{{cite journal | author=Wang CL |title=Caldesmon and smooth-muscle regulation. |journal=Cell Biochem. Biophys. |volume=35 |issue= 3 |pages= 275-88 |year= 2002 |pmid= 11894847 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CAMK4... {November 9, 2007 5:24:01 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 5:24:43 PM PST}
- CREATED: Created new protein page: CAMK4 {November 9, 2007 5:24:50 PM PST}
- INFO: Beginning work on CD151... {November 9, 2007 5:24:50 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:25:35 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD151 molecule (Raph blood group)
| HGNCid = 1630
| Symbol = CD151
| AltSymbols =; GP27; MER2; PETA-3; RAPH; SFA1; TSPAN24
| OMIM = 602243
| ECnumber =
| Homologene = 20916
| MGIid = 1096360
| GeneAtlas_image1 = PBB_GE_CD151_204306_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 977
| Hs_Ensembl = ENSG00000177697
| Hs_RefseqProtein = NP_001034579
| Hs_RefseqmRNA = NM_001039490
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 822961
| Hs_GenLoc_end = 828830
| Hs_Uniprot = P48509
| Mm_EntrezGene = 12476
| Mm_Ensembl = ENSMUSG00000025510
| Mm_RefseqmRNA = NM_009842
| Mm_RefseqProtein = NP_033972
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 141320142
| Mm_GenLoc_end = 141322788
| Mm_Uniprot = Q921J7
}}
}}
'''CD151 molecule (Raph blood group)''', also known as '''CD151''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.<ref>{{cite web | title = Entrez Gene: CD151 CD151 molecule (Raph blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=977| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143-51 |year= 2002 |pmid= 11739647 |doi= }}
*{{cite journal | author=Ashman LK |title=CD151. |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 3 |pages= 223-6 |year= 2003 |pmid= 12456024 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CXCL11... {November 9, 2007 5:27:54 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CXCL11 image.jpg {November 9, 2007 5:28:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:29:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CXCL11_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1rjt.
| PDB = {{PDB2|1rjt}}
| Name = Chemokine (C-X-C motif) ligand 11
| HGNCid = 10638
| Symbol = CXCL11
| AltSymbols =; H174; I-TAC; IP-9; IP9; MGC102770; SCYB11; SCYB9B; b-R1
| OMIM = 604852
| ECnumber =
| Homologene = 3944
| MGIid = 1860203
| GeneAtlas_image1 = PBB_GE_CXCL11_210163_at_tn.png
| GeneAtlas_image2 = PBB_GE_CXCL11_211122_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008009 |text = chemokine activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6373
| Hs_Ensembl = ENSG00000169248
| Hs_RefseqProtein = NP_005400
| Hs_RefseqmRNA = NM_005409
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 77173975
| Hs_GenLoc_end = 77176376
| Hs_Uniprot = O14625
| Mm_EntrezGene = 56066
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_019494
| Mm_RefseqProtein = NP_062367
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Chemokine (C-X-C motif) ligand 11''', also known as '''CXCL11''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene.<ref>{{cite web | title = Entrez Gene: CXCL11 chemokine (C-X-C motif) ligand 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6373| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CXCL5... {November 9, 2007 5:29:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:30:12 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine (C-X-C motif) ligand 5
| HGNCid = 10642
| Symbol = CXCL5
| AltSymbols =; ENA-78; SCYB5
| OMIM = 600324
| ECnumber =
| Homologene = 88672
| MGIid =
| GeneAtlas_image1 = PBB_GE_CXCL5_214974_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_CXCL5_215101_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008009 |text = chemokine activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6374
| Hs_Ensembl = ENSG00000163735
| Hs_RefseqProtein = NP_002985
| Hs_RefseqmRNA = NM_002994
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 75080224
| Hs_GenLoc_end = 75083280
| Hs_Uniprot = P42830
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Chemokine (C-X-C motif) ligand 5''', also known as '''CXCL5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is an inflammatory chemokine that belongs to the CXC chemokine family. This chemokine is produced concomitantly with interleukin-8 (IL8) in response to stimulation with either interleukin-1 (IL1) or tumor necrosis factor-alpha (TNFA). This chemokine is a potent chemotaxin involved in neutrophil activation.<ref>{{cite web | title = Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6374| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Walz A, Schmutz P, Mueller C, Schnyder-Candrian S |title=Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease. |journal=J. Leukoc. Biol. |volume=62 |issue= 5 |pages= 604-11 |year= 1997 |pmid= 9365115 |doi= }}
*{{cite journal | author=Struyf S, Proost P, Van Damme J |title=Regulation of the immune response by the interaction of chemokines and proteases. |journal=Adv. Immunol. |volume=81 |issue= |pages= 1-44 |year= 2004 |pmid= 14711052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FOXP2... {November 9, 2007 5:45:44 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 5:46:24 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:46:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FOXP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2a07.
| PDB = {{PDB2|2a07}}, {{PDB2|2as5}}
| Name = Forkhead box P2
| HGNCid = 13875
| Symbol = FOXP2
| AltSymbols =; CAGH44; DKFZp686H1726; SPCH1; TNRC10
| OMIM = 605317
| ECnumber =
| Homologene = 33482
| MGIid = 2148705
| GeneAtlas_image1 = PBB_GE_FOXP2_gnf1h09377_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0021757 |text = caudate nucleus development}} {{GNF_GO|id=GO:0021758 |text = putamen development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 93986
| Hs_Ensembl = ENSG00000128573
| Hs_RefseqProtein = NP_055306
| Hs_RefseqmRNA = NM_014491
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 113842288
| Hs_GenLoc_end = 114117219
| Hs_Uniprot = O15409
| Mm_EntrezGene = 114142
| Mm_Ensembl = ENSMUSG00000029563
| Mm_RefseqmRNA = NM_053242
| Mm_RefseqProtein = NP_444472
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 15135506
| Mm_GenLoc_end = 15391977
| Mm_Uniprot = Q8BQ27
}}
}}
'''Forkhead box P2''', also known as '''FOXP2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an evolutionarily conserved transcription factor expressed in fetal and adult brain. This transcription factor is a member of the forkhead/winged-helix (FOX) family of transcription factors, and contains a FOX DNA-binding domain and a large polyglutamine tract. Members of the FOX family of transcription factors are regulators of embryogenesis. The product of this gene is thought to be required for proper development of speech and language regions of the brain during embryogenesis. Although a point mutation in this gene has been associated with the KE pedigree segregating developmental verbal dyspraxia, no association between mutations in this gene and another speech disorder, autism, has been found. Four alternative transcripts encoding three different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: FOXP2 forkhead box P2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93986| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Vargha-Khadem F, Gadian DG, Copp A, Mishkin M |title=FOXP2 and the neuroanatomy of speech and language. |journal=Nat. Rev. Neurosci. |volume=6 |issue= 2 |pages= 131-8 |year= 2005 |pmid= 15685218 |doi= 10.1038/nrn1605 }}
*{{cite journal | author=Benítez-Burraco A |title=[FOXP2: from the specific disorder to the molecular biology of language. I. Aetiological, neuroanatomical, neurophysiological and molecular aspects] |journal=Revista de neurologia |volume=40 |issue= 11 |pages= 671-82 |year= 2005 |pmid= 15948071 |doi= }}
*{{cite journal | author=Lennon PA, Cooper ML, Peiffer DA, ''et al.'' |title=Deletion of 7q31.1 supports involvement of FOXP2 in language impairment: clinical report and review. |journal=Am. J. Med. Genet. A |volume=143 |issue= 8 |pages= 791-8 |year= 2007 |pmid= 17330859 |doi= 10.1002/ajmg.a.31632 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GAB2... {November 9, 2007 5:43:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:44:19 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = GRB2-associated binding protein 2
| HGNCid = 14458
| Symbol = GAB2
| AltSymbols =; KIAA0571
| OMIM = 606203
| ECnumber =
| Homologene = 69067
| MGIid = 1333854
| GeneAtlas_image1 = PBB_GE_GAB2_203853_s_at_tn.png
| Function =
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9846
| Hs_Ensembl = ENSG00000033327
| Hs_RefseqProtein = NP_036428
| Hs_RefseqmRNA = NM_012296
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 77603990
| Hs_GenLoc_end = 77806414
| Hs_Uniprot = Q9UQC2
| Mm_EntrezGene = 14389
| Mm_Ensembl = ENSMUSG00000004508
| Mm_RefseqmRNA = NM_010248
| Mm_RefseqProtein = NP_034378
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 96956943
| Mm_GenLoc_end = 97180228
| Mm_Uniprot = Q3ZB56
}}
}}
'''GRB2-associated binding protein 2''', also known as '''GAB2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: GAB2 GRB2-associated binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9846| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hibi M, Hirano T |title=Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors. |journal=Leuk. Lymphoma |volume=37 |issue= 3-4 |pages= 299-307 |year= 2000 |pmid= 10752981 |doi= }}
*{{cite journal | author=Gold MR, Ingham RJ, McLeod SJ, ''et al.'' |title=Targets of B-cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap1 GTPase. |journal=Immunol. Rev. |volume=176 |issue= |pages= 47-68 |year= 2001 |pmid= 11043767 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RPS6KA2... {November 9, 2007 5:25:35 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:26:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ribosomal protein S6 kinase, 90kDa, polypeptide 2
| HGNCid = 10431
| Symbol = RPS6KA2
| AltSymbols =; HU-2; RSK; MAPKAPK1C; RSK3; S6K-alpha; S6K-alpha2; p90-RSK3; pp90RSK3
| OMIM = 601685
| ECnumber =
| Homologene = 36318
| MGIid = 1342290
| GeneAtlas_image1 = PBB_GE_RPS6KA2_204906_at_tn.png
| GeneAtlas_image2 = PBB_GE_RPS6KA2_212912_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6196
| Hs_Ensembl = ENSG00000071242
| Hs_RefseqProtein = NP_001006933
| Hs_RefseqmRNA = NM_001006932
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 166742844
| Hs_GenLoc_end = 167195791
| Hs_Uniprot = Q15349
| Mm_EntrezGene = 20112
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_489703
| Mm_RefseqProtein = XP_489703
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Ribosomal protein S6 kinase, 90kDa, polypeptide 2''', also known as '''RPS6KA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6196| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on S100A6... {November 9, 2007 5:26:58 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein S100A6 image.jpg {November 9, 2007 5:27:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:27:54 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_S100A6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a03.
| PDB = {{PDB2|1a03}}, {{PDB2|1cnp}}, {{PDB2|1jwd}}, {{PDB2|1k8u}}, {{PDB2|1k96}}, {{PDB2|1k9k}}, {{PDB2|1k9p}}, {{PDB2|2cnp}}
| Name = S100 calcium binding protein A6
| HGNCid = 10496
| Symbol = S100A6
| AltSymbols =; 2A9; 5B10; CABP; CACY; PRA
| OMIM = 114110
| ECnumber =
| Homologene = 7925
| MGIid = 1339467
| GeneAtlas_image1 = PBB_GE_S100A6_217728_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0048154 |text = S100 beta binding}} {{GNF_GO|id=GO:0048306 |text = calcium-dependent protein binding}}
| Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007409 |text = axonogenesis}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0048146 |text = positive regulation of fibroblast proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6277
| Hs_Ensembl = ENSG00000197956
| Hs_RefseqProtein = NP_055439
| Hs_RefseqmRNA = NM_014624
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 151773699
| Hs_GenLoc_end = 151775344
| Hs_Uniprot = P06703
| Mm_EntrezGene = 20200
| Mm_Ensembl = ENSMUSG00000001025
| Mm_RefseqmRNA = NM_011313
| Mm_RefseqProtein = NP_035443
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 90699108
| Mm_GenLoc_end = 90700341
| Mm_Uniprot = Q545I9
}}
}}
'''S100 calcium binding protein A6''', also known as '''S100A6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.<ref>{{cite web | title = Entrez Gene: S100A6 S100 calcium binding protein A6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6277| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134-40 |year= 1996 |pmid= 8701470 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SFRP1... {November 9, 2007 5:30:12 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:32:21 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Secreted frizzled-related protein 1
| HGNCid = 10776
| Symbol = SFRP1
| AltSymbols =; FRP1; FRP; FRP-1; FrzA; SARP2
| OMIM = 604156
| ECnumber =
| Homologene = 2266
| MGIid = 892014
| GeneAtlas_image1 = PBB_GE_SFRP1_202037_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SFRP1_202035_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SFRP1_202036_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001756 |text = somitogenesis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6422
| Hs_Ensembl = ENSG00000104332
| Hs_RefseqProtein = NP_003003
| Hs_RefseqmRNA = NM_003012
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 41238640
| Hs_GenLoc_end = 41286149
| Hs_Uniprot = Q8N474
| Mm_EntrezGene = 20377
| Mm_Ensembl = ENSMUSG00000031548
| Mm_RefseqmRNA = NM_013834
| Mm_RefseqProtein = NP_038862
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 24877063
| Mm_GenLoc_end = 24915179
| Mm_Uniprot = Q505A2
}}
}}
'''Secreted frizzled-related protein 1''', also known as '''SFRP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP1 and SFRP5 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP1 is expressed in several human tissues, with the highest levels in heart.<ref>{{cite web | title = Entrez Gene: SFRP1 secreted frizzled-related protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6422| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SILV... {November 9, 2007 5:32:21 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:33:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Silver homolog (mouse)
| HGNCid = 10880
| Symbol = SILV
| AltSymbols =; SI; D12S53E; ME20; PMEL17; SIL; gp100
| OMIM = 155550
| ECnumber =
| Homologene = 5048
| MGIid = 98301
| GeneAtlas_image1 = PBB_GE_SILV_209848_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006583 |text = melanin biosynthetic process from tyrosine}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6490
| Hs_Ensembl = ENSG00000185664
| Hs_RefseqProtein = NP_008859
| Hs_RefseqmRNA = NM_006928
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 54634157
| Hs_GenLoc_end = 54646765
| Hs_Uniprot = P40967
| Mm_EntrezGene = 20431
| Mm_Ensembl = ENSMUSG00000025359
| Mm_RefseqmRNA = NM_021882
| Mm_RefseqProtein = NP_068682
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 128109207
| Mm_GenLoc_end = 128123073
| Mm_Uniprot = Q60696
}}
}}
'''Silver homolog (mouse)''', also known as '''SILV''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC3A1... {November 9, 2007 5:33:09 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:33:59 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
| HGNCid = 11025
| Symbol = SLC3A1
| AltSymbols =; ATR1; CSNU1; D2H; FLJ34681; NBAT; RBAT
| OMIM = 104614
| ECnumber =
| Homologene = 37289
| MGIid = 1195264
| GeneAtlas_image1 = PBB_GE_SLC3A1_205799_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0015174 |text = basic amino acid transmembrane transporter activity}} {{GNF_GO|id=GO:0015184 |text = L-cystine transmembrane transporter activity}} {{GNF_GO|id=GO:0043169 |text = cation binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005743 |text = mitochondrial inner membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006520 |text = amino acid metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0015802 |text = basic amino acid transport}} {{GNF_GO|id=GO:0015811 |text = L-cystine transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6519
| Hs_Ensembl = ENSG00000138079
| Hs_RefseqProtein = NP_000332
| Hs_RefseqmRNA = NM_000341
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 44356103
| Hs_GenLoc_end = 44402137
| Hs_Uniprot = Q07837
| Mm_EntrezGene = 20532
| Mm_Ensembl = ENSMUSG00000024131
| Mm_RefseqmRNA = XM_001003828
| Mm_RefseqProtein = XP_001003828
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 84936702
| Mm_GenLoc_end = 84972562
| Mm_Uniprot =
}}
}}
'''Solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1''', also known as '''SLC3A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC9A3R2... {November 9, 2007 5:42:37 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SLC9A3R2 image.jpg {November 9, 2007 5:43:09 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 5:43:38 PM PST}
- CREATED: Created new protein page: SLC9A3R2 {November 9, 2007 5:43:45 PM PST}
- INFO: Beginning work on STX4... {November 9, 2007 5:34:46 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 5:35:22 PM PST}
- CREATED: Created new protein page: STX4 {November 9, 2007 5:35:29 PM PST}
- INFO: Beginning work on SULT2A1... {November 9, 2007 5:35:29 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SULT2A1 image.jpg {November 9, 2007 5:36:54 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:37:20 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SULT2A1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1efh.
| PDB = {{PDB2|1efh}}, {{PDB2|1j99}}, {{PDB2|1ov4}}
| Name = Sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
| HGNCid = 11458
| Symbol = SULT2A1
| AltSymbols =; HST; ST2; DHEA-ST; ST2A3; STD; hSTa
| OMIM = 125263
| ECnumber =
| Homologene = 37741
| MGIid = 3690091
| GeneAtlas_image1 = PBB_GE_SULT2A1_206292_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SULT2A1_206293_at_tn.png
| Function = {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0047704 |text = bile-salt sulfotransferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}} {{GNF_GO|id=GO:0030573 |text = bile acid catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6822
| Hs_Ensembl = ENSG00000105398
| Hs_RefseqProtein = NP_003158
| Hs_RefseqmRNA = NM_003167
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 53065682
| Hs_GenLoc_end = 53081405
| Hs_Uniprot = Q06520
| Mm_EntrezGene = 20865
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_987548
| Mm_RefseqProtein = XP_992642
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1''', also known as '''SULT2A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene is primarily expressed in liver and adrenal tissues where the encoded protein sulfates steroids and bile acids.<ref>{{cite web | title = Entrez Gene: SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6822| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Weinshilboum RM, Otterness DM, Aksoy IA, ''et al.'' |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3-14 |year= 1997 |pmid= 9034160 |doi= }}
*{{cite journal | author=Glatt H, Engelke CE, Pabel U, ''et al.'' |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112-113 |issue= |pages= 341-8 |year= 2000 |pmid= 10720750 |doi= }}
*{{cite journal | author=Glatt H, Boeing H, Engelke CE, ''et al.'' |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. |journal=Mutat. Res. |volume=482 |issue= 1-2 |pages= 27-40 |year= 2001 |pmid= 11535246 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SUMO2... {November 9, 2007 5:33:59 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SUMO2 image.jpg {November 9, 2007 5:34:11 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 5:34:37 PM PST}
- CREATED: Created new protein page: SUMO2 {November 9, 2007 5:34:46 PM PST}
- INFO: Beginning work on TBXAS1... {November 9, 2007 5:37:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:38:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)
| HGNCid = 11609
| Symbol = TBXAS1
| AltSymbols =; TS; CYP5; CYP5A1; THAS; TXAS; TXS
| OMIM = 274180
| ECnumber =
| Homologene = 55549
| MGIid = 98497
| GeneAtlas_image1 = PBB_GE_TBXAS1_208130_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004796 |text = thromboxane-A synthase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0016712 |text = oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001516 |text = prostaglandin biosynthetic process}} {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006633 |text = fatty acid biosynthetic process}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6916
| Hs_Ensembl = ENSG00000059377
| Hs_RefseqProtein = NP_001052
| Hs_RefseqmRNA = NM_001061
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 139124668
| Hs_GenLoc_end = 139366560
| Hs_Uniprot = P24557
| Mm_EntrezGene = 21391
| Mm_Ensembl = ENSMUSG00000029925
| Mm_RefseqmRNA = NM_011539
| Mm_RefseqProtein = NP_035669
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 38848593
| Mm_GenLoc_end = 39014194
| Mm_Uniprot = Q3UTF0
}}
}}
'''Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)''', also known as '''TBXAS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. The gene expresses two transcript variants.<ref>{{cite web | title = Entrez Gene: TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6916| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Shen RF, Tai HH |title=Thromboxanes: synthase and receptors. |journal=J. Biomed. Sci. |volume=5 |issue= 3 |pages= 153-72 |year= 1998 |pmid= 9678486 |doi= }}
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Wang LH, Kulmacz RJ |title=Thromboxane synthase: structure and function of protein and gene. |journal=Prostaglandins Other Lipid Mediat. |volume=68-69 |issue= |pages= 409-22 |year= 2003 |pmid= 12432933 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TFF2... {November 9, 2007 5:38:10 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:39:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Trefoil factor 2 (spasmolytic protein 1)
| HGNCid = 11756
| Symbol = TFF2
| AltSymbols =; SML1; SP
| OMIM = 182590
| ECnumber =
| Homologene = 3956
| MGIid = 1306805
| GeneAtlas_image1 = PBB_GE_TFF2_214476_at_tn.png
| Function =
| Component =
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007586 |text = digestion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7032
| Hs_Ensembl = ENSG00000160181
| Hs_RefseqProtein = NP_005414
| Hs_RefseqmRNA = NM_005423
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 42639538
| Hs_GenLoc_end = 42644176
| Hs_Uniprot = Q03403
| Mm_EntrezGene = 21785
| Mm_Ensembl = ENSMUSG00000024028
| Mm_RefseqmRNA = NM_009363
| Mm_RefseqProtein = NP_033389
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 30868938
| Mm_GenLoc_end = 30871294
| Mm_Uniprot = Q80YV5
}}
}}
'''Trefoil factor 2 (spasmolytic protein 1)''', also known as '''TFF2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.<ref>{{cite web | title = Entrez Gene: TFF2 trefoil factor 2 (spasmolytic protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7032| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Advenier C, Lagente V, Boichot E |title=The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. |journal=Eur. Respir. J. |volume=10 |issue= 8 |pages= 1892-906 |year= 1997 |pmid= 9272936 |doi= }}
*{{cite journal | author=Langer G, Jagla W, Behrens-Baumann W, ''et al.'' |title=Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells. |journal=Adv. Exp. Med. Biol. |volume=506 |issue= Pt A |pages= 313-6 |year= 2003 |pmid= 12613926 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TGFBR3... {November 9, 2007 5:39:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:39:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transforming growth factor, beta receptor III
| HGNCid = 11774
| Symbol = TGFBR3
| AltSymbols =; BGCAN; betaglycan
| OMIM = 600742
| ECnumber =
| Homologene = 2436
| MGIid = 104637
| GeneAtlas_image1 = PBB_GE_TGFBR3_204731_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005539 |text = glycosaminoglycan binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7049
| Hs_Ensembl = ENSG00000069702
| Hs_RefseqProtein = NP_003234
| Hs_RefseqmRNA = NM_003243
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 91918488
| Hs_GenLoc_end = 92144147
| Hs_Uniprot = Q03167
| Mm_EntrezGene = 21814
| Mm_Ensembl = ENSMUSG00000029287
| Mm_RefseqmRNA = NM_011578
| Mm_RefseqProtein = NP_035708
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 107346872
| Mm_GenLoc_end = 107529822
| Mm_Uniprot = Q3TM82
}}
}}
'''Transforming growth factor, beta receptor III''', also known as '''TGFBR3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Massagué J |title=Receptors for the TGF-beta family. |journal=Cell |volume=69 |issue= 7 |pages= 1067-70 |year= 1992 |pmid= 1319842 |doi= }}
*{{cite journal | author=Border WA, Noble NA |title=Transforming growth factor beta in tissue fibrosis. |journal=N. Engl. J. Med. |volume=331 |issue= 19 |pages= 1286-92 |year= 1994 |pmid= 7935686 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TK1... {November 9, 2007 5:39:39 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TK1 image.jpg {November 9, 2007 5:40:13 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 5:40:23 PM PST}
- CREATED: Created new protein page: TK1 {November 9, 2007 5:40:30 PM PST}
- INFO: Beginning work on USF2... {November 9, 2007 5:40:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:41:38 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Upstream transcription factor 2, c-fos interacting
| HGNCid = 12594
| Symbol = USF2
| AltSymbols =; FIP
| OMIM = 600390
| ECnumber =
| Homologene = 2527
| MGIid = 99961
| GeneAtlas_image1 = PBB_GE_USF2_202152_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_USF2_214879_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_USF2_215737_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007595 |text = lactation}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7392
| Hs_Ensembl = ENSG00000105698
| Hs_RefseqProtein = NP_003358
| Hs_RefseqmRNA = NM_003367
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 40451721
| Hs_GenLoc_end = 40462558
| Hs_Uniprot = Q15853
| Mm_EntrezGene = 22282
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001001413
| Mm_RefseqProtein = XP_001001413
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Upstream transcription factor 2, c-fos interacting''', also known as '''USF2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.<ref>{{cite web | title = Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7392| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Corre S, Galibert MD |title=[USF as a key regulatory element of gene expression] |journal=Med Sci (Paris) |volume=22 |issue= 1 |pages= 62-7 |year= 2006 |pmid= 16386222 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on WNK1... {November 9, 2007 5:44:19 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein WNK1 image.jpg {November 9, 2007 5:45:28 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:45:44 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_WNK1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1t4h.
| PDB = {{PDB2|1t4h}}
| Name = WNK lysine deficient protein kinase 1
| HGNCid = 14540
| Symbol = WNK1
| AltSymbols =; KDP; KIAA0344; PHA2C; PRKWNK1
| OMIM = 605232
| ECnumber =
| Homologene = 14253
| MGIid = 2442092
| GeneAtlas_image1 = PBB_GE_WNK1_211992_at_tn.png
| GeneAtlas_image2 = PBB_GE_WNK1_211993_at_tn.png
| GeneAtlas_image3 = PBB_GE_WNK1_211994_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004860 |text = protein kinase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0042598 |text = vesicular fraction}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0050794 |text = regulation of cellular process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 65125
| Hs_Ensembl = ENSG00000060237
| Hs_RefseqProtein = NP_061852
| Hs_RefseqmRNA = NM_018979
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 732993
| Hs_GenLoc_end = 888219
| Hs_Uniprot = Q9H4A3
| Mm_EntrezGene = 232341
| Mm_Ensembl = ENSMUSG00000045962
| Mm_RefseqmRNA = XM_001004362
| Mm_RefseqProtein = XP_001004362
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 119889590
| Mm_GenLoc_end = 120004226
| Mm_Uniprot = Q3TU87
}}
}}
'''WNK lysine deficient protein kinase 1''', also known as '''WNK1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The WNK1 gene encodes a cytoplasmic serine-threonine kinase expressed in distal nephron.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: WNK1 WNK lysine deficient protein kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65125| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hart GW, Haltiwanger RS, Holt GD, Kelly WG |title=Nucleoplasmic and cytoplasmic glycoproteins. |journal=Ciba Found. Symp. |volume=145 |issue= |pages= 102-12, discussion 112-8 |year= 1989 |pmid= 2507249 |doi= }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
*{{cite journal | author=Xu BE, Lee BH, Min X, ''et al.'' |title=WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension. |journal=Cell Res. |volume=15 |issue= 1 |pages= 6-10 |year= 2005 |pmid= 15686619 |doi= 10.1038/sj.cr.7290256 }}
*{{cite journal | author=Subramanya AR, Yang CL, McCormick JA, Ellison DH |title=WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron. |journal=Kidney Int. |volume=70 |issue= 4 |pages= 630-4 |year= 2006 |pmid= 16820787 |doi= 10.1038/sj.ki.5001634 }}
}}
{{refend}}
{{protein-stub}}
end log.
