Calcitonin receptor

CALCR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5II0
Identifiers
Aliases	CALCR, CRT, CT-R, CTR, CTR1, calcitonin receptor
External IDs	OMIM: 114131; MGI: 101950; HomoloGene: 1320; GeneCards: CALCR; OMA:CALCR - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	93,574,730 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	3,764,714 bp
RNA expression pattern
	Top expressed in
	tibia; ; hypothalamus; ; muscle of thigh; ; human kidney; ; placenta; ; metanephros; ; skeletal muscle tissue; ; renal cortex; ; ligament; ; tendon;
	Top expressed in
	arcuate nucleus; ; median eminence; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; suprachiasmatic nucleus; ; nucleus accumbens; ; morula; ; lateral hypothalamus; ; ventromedial nucleus; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; calcitonin receptor activity; calcitonin binding; signal transducer activity; protein binding; transmembrane signaling receptor activity; amyloid-beta binding; calcitonin gene-related peptide receptor activity; amylin receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; axon; amylin receptor complex 1; amylin receptor complex 2; amylin receptor complex 3;
Biological process	positive regulation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; receptor internalization; response to glucocorticoid; activation of phospholipase C activity; activation of adenylate cyclase activity; cell surface receptor signaling pathway; protein transport; protein localization to plasma membrane; signal transduction; G protein-coupled receptor signaling pathway; positive regulation of gene expression; positive regulation of protein kinase A signaling; positive regulation of cell death; positive regulation of peptidyl-serine phosphorylation; cross-receptor inhibition within G protein-coupled receptor heterodimer; positive regulation of protein kinase B signaling; positive regulation of ERK1 and ERK2 cascade; amylin receptor signaling pathway; response to amyloid-beta; positive regulation of calcium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	799
	12311
	ENSG00000004948
	ENSMUSG00000023964
	P30988
	Q60755
	NM_001742; NM_001164737; NM_001164738
	NM_001042725; NM_007588; NM_001355192; NM_001377018
	NP_001158209; NP_001158210; NP_001733
	NP_001036190; NP_031614; NP_001342121; NP_001363947
	Wikidata
View/Edit Human	View/Edit Mouse

The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis,^[5] particularly with respect to bone formation and metabolism.^[6]^[7]^[8]

CT works by activating the G-proteins G_s and G_q often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain.^[9] It may also affect the ovaries in women and the testes in men.

The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY₁ (CT + RAMP1), AMY₂ (CT + RAMP2), and AMY₃ (CT+ RAMP3).^[10]

Preclinical studies have suggested that dual amylin and calcitonin receptor agonists may be more effective than amylin receptor agonists for obesity and type II diabetes.^[11]

Interactions

Calcitonin receptor has been shown to interact with Apolipoprotein B^[12]^[13] and LRP1.^[14]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000004948 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023964 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Purdue BW, Tilakaratne N, Sexton PM (2002). "Molecular pharmacology of the calcitonin receptor". Receptors & Channels. 8 (3–4): 243–255. doi:10.1080/10606820213681. PMID 12529940.
^ Chambers TJ, Magnus CJ (January 1982). "Calcitonin alters behaviour of isolated osteoclasts". The Journal of Pathology. 136 (1): 27–39. doi:10.1002/path.1711360104. PMID 7057295. S2CID 8395420.
^ Dacquin R, Davey RA, Laplace C, Levasseur R, Morris HA, Goldring SR, et al. (February 2004). "Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo". The Journal of Cell Biology. 164 (4): 509–514. doi:10.1083/jcb.200312135. PMC 2171986. PMID 14970190.
^ Davey RA, Turner AG, McManus JF, Chiu WS, Tjahyono F, Moore AJ, et al. (August 2008). "Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice". Journal of Bone and Mineral Research. 23 (8): 1182–1193. doi:10.1359/jbmr.080310. PMC 2680171. PMID 18627265.
^ senselab Archived February 28, 2009, at the Wayback Machine
^ "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-12.
^ Sonne N, Karsdal MA, Henriksen K (April 2021). "Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases". Molecular Metabolism. 46: 101109. doi:10.1016/j.molmet.2020.101109. PMC 8085567. PMID 33166741.
^ Zhang J, Herscovitz H (February 2003). "Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B". The Journal of Biological Chemistry. 278 (9): 7459–7468. doi:10.1074/jbc.M207976200. PMID 12397072.
^ Linnik KM, Herscovitz H (August 1998). "Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state". The Journal of Biological Chemistry. 273 (33): 21368–21373. doi:10.1074/jbc.273.33.21368. PMID 9694898.
^ Orr AW, Pedraza CE, Pallero MA, Elzie CA, Goicoechea S, Strickland DK, et al. (June 2003). "Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly". The Journal of Cell Biology. 161 (6): 1179–1189. doi:10.1083/jcb.200302069. PMC 2172996. PMID 12821648.

External links

"Calcitonin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-07-23.
Calcitonin+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000004948 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023964 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12529940-5] Purdue BW, Tilakaratne N, Sexton PM (2002). "Molecular pharmacology of the calcitonin receptor". Receptors & Channels. 8 (3–4): 243–255. doi:10.1080/10606820213681. PMID 12529940.

[pmid7057295-6] Chambers TJ, Magnus CJ (January 1982). "Calcitonin alters behaviour of isolated osteoclasts". The Journal of Pathology. 136 (1): 27–39. doi:10.1002/path.1711360104. PMID 7057295. S2CID 8395420.

[pmid14970190-7] Dacquin R, Davey RA, Laplace C, Levasseur R, Morris HA, Goldring SR, et al. (February 2004). "Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo". The Journal of Cell Biology. 164 (4): 509–514. doi:10.1083/jcb.200312135. PMC 2171986. PMID 14970190.

[pmid18627265-8] Davey RA, Turner AG, McManus JF, Chiu WS, Tjahyono F, Moore AJ, et al. (August 2008). "Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice". Journal of Bone and Mineral Research. 23 (8): 1182–1193. doi:10.1359/jbmr.080310. PMC 2680171. PMID 18627265.

[9] senselab Archived February 28, 2009, at the Wayback Machine

[IUPHAR-DB-10] "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-12.

[11] Sonne N, Karsdal MA, Henriksen K (April 2021). "Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases". Molecular Metabolism. 46: 101109. doi:10.1016/j.molmet.2020.101109. PMC 8085567. PMID 33166741.

[pmid12397072-12] Zhang J, Herscovitz H (February 2003). "Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B". The Journal of Biological Chemistry. 278 (9): 7459–7468. doi:10.1074/jbc.M207976200. PMID 12397072.

[pmid9694898-13] Linnik KM, Herscovitz H (August 1998). "Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state". The Journal of Biological Chemistry. 273 (33): 21368–21373. doi:10.1074/jbc.273.33.21368. PMID 9694898.

[pmid12821648-14] Orr AW, Pedraza CE, Pallero MA, Elzie CA, Goicoechea S, Strickland DK, et al. (June 2003). "Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly". The Journal of Cell Biology. 161 (6): 1179–1189. doi:10.1083/jcb.200302069. PMC 2172996. PMID 12821648.

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Interactions

References

Further reading

External links