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Trimethylamine-corrinoid protein Co-methyltransferase

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Trimethylamine-corrinoid protein Co-methyltransferase
Identifiers
EC no.2.1.1.250
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Trimethylamine-corrinoid protein Co-methyltransferase (EC 2.1.1.250, mttB (gene), trimethylamine methyltransferase) is an enzyme with systematic name trimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

trimethylamine + [Co(I) trimethylamine-specific corrinoid protein] [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine

This enzyme is involved in methanogenesis from trimethylamine.

References

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  1. ^ Ferguson DJ, Krzycki JA (February 1997). "Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri". Journal of Bacteriology. 179 (3): 846–52. doi:10.1128/jb.179.3.846-852.1997. PMC 178769. PMID 9006042.
  2. ^ Krzycki JA (October 2004). "Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases". Current Opinion in Chemical Biology. 8 (5): 484–91. doi:10.1016/j.cbpa.2004.08.012. PMID 15450490.
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