Talk:Choroid plexus

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i am looking for an artical that describes the chemical composition of cerebral spinal fluid, and a discription of the different types of protens present in CSF.

What do you think leads to the calcification of the choroid plexus...other than the symptoms of neurofibromatosis? DrGladwin 04:14, 27 May 2007 (UTC)[reply]

I hope get more detailness of the choroid plexus,clearly. —Preceding unsigned comment added by 218.216.185.20 (talk) 08:12, 20 August 2010 (UTC)[reply]

Hi, I don't know enough about the subject to edit anything, but as written I find it very confusing. This page, and many books and other web sites tell us that the CP filters plasma, or that CSF is made by filtering plasma. This implies a passive process, a bit like what happens to plasma in the Glomerulus of the kidney. But then we are also told that "the CP epithelial layer has tight junctions in between the cells on the side facing the ventricle (apical surface). These tight junctions prevent the majority of substances from crossing the cell layer into the CSF; thus the CP acts as a blood-CSF barrier" - ie nothing can be "filtered". The reader is then informed that "CP epithelial cells actively transport sodium, chloride and bicarbonate ions into the ventricles and water follows the resulting osmotic gradient." If this latter statement describes how CSF is really formed, then the word "filtration" should not be used in the description of CSF formation?Pysifr (talk) 10:18, 1 October 2013 (UTC)[reply]

Grammar

What would be the plural of "choroid plexus"? Would it be "choroid plexi" or what? The grammar used in the article is very inconsistent. ForestAngel (talk) 06:17, 13 December 2010 (UTC)[reply]

should mention calcification of the CP

The page should mention calcification of the CP. How common is calcification? What are the effects of calcification? Has anyone ever reversed CP calcification? Encyclopedant (talk) 20:26, 24 October 2014 (UTC)[reply]

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How does pia get into the Choroid Plexus?

(I've asked this same question over under pia). I've seen that there is pia inside choroid plexus, and I can't for the life of me figure out how it gets there, since pia is on the outside of the brain, and ventricles with choroid plexus are on the inside of the brain (except in relation to the 4th ventricle, which is in the dorsal aspect of the brain stem, and therefore adjacent to the pia). So I'm conjecturing that maybe the pia follows blood vessels into the brain, but I haven't found anything which verifies that. I've read some about the perivascular space, but I'm not sure that answers my question. Does anyone know if pia follows blood vessels into the brain?UnderEducatedGeezer (talk) 23:10, 25 December 2019 (UTC)[reply]

Hello UnderEducatedGeezer the Tela choroidea page may make things a bit clearer. Also the choroid plexus is developed in the embryo while the ventricles are being developed. I hope to be able to add to the pages soon. Best --Iztwoz (talk) 20:58, 28 December 2019 (UTC)[reply]

Thanks Iztwoz, I'd discovered the concept of the Tela choroidea, also the perivascular space, in relation the to choroid plexus, but neither seemed to help very much to see where the pia came from, given the distance of most pia from the ventricles. I'm glad to see you may be adding to the pages soon! And it is helpful to be reminded that CP is developed in embryo, rather than an ongoing developing structure. Maybe that figures into answer somehow? I haven't got any into brain development yet, still stuck at basics of brain anatomy. I'll keep looking too. Regards. UnderEducatedGeezer (talk) 12:32, 30 December 2019 (UTC)[reply]

Hi Iztwoz, I found something, but I'm not too sure about it. It's at https://www.ncbi.nlm.nih.gov/books/NBK539882/ , Neuroanatomy, Cranial Meninges , at StatPearls, in the section Pia Mater, and says in part, "Importantly, the cerebral pia mater forms sheaths around the blood vessels that enter and exit the brain perpendicular to the meninges, specifically from the subarachnoid space to within the brain parenchyma." But I wonder if that's actually true (though it's what I had thought would likely be happening), because that publication explicitly warns user to verify information published there, and I found what I suspect is a gross typo earlier in that same paper, where it says, "Importantly, there is an opening in the falx cerebri, known as the tentorial incisura (sometimes referred to as the tentorial notch), that allows the midbrain to pass through into middle cranial fossa." As far as I've read, the tentorial incisura is not in the falx cerebri at all, but is in the tentorium cerebelli (which is between the cerebellum and occipital lobes, rather than between the two hemispheres as is the falx cerebri). I guess it's just a typo, but it's kind of an important typo, & leads me to feel dubious about what I was in fact looking for. UnderEducatedGeezer (talk) 10:11, 1 January 2020 (UTC)[reply]

I also found, "At the point where blood vessels enter the underlying neural tissue, extensions of the pia mater are carried with them creating a perivascular space 1.", at https://radiopaedia.org/articles/pia-mater . I've just not found anything which directly says the pia found in the choroid plexus comes in to it by following the capillaries, which is surprising me. UnderEducatedGeezer (talk) 10:11, 1 January 2020 (UTC)[reply]

Thanks UEG but am focusing on another page at the moment so will look again soon. (Radiopedia is usually a good source) I'm pretty sure that that is not the entry point for the choroid plexus. Best--Iztwoz (talk) 10:49, 1 January 2020 (UTC)t[reply]

Ok Iztwoz, I know that you're a very busy & top-of-the-line editor! The best I've found so far about pia & choroid is, "Each sulcus contains blood vessels which lie just outside the pia. Each vessel that enters the brain carries a sleeve of pia with it.", at https://aclandanatomy.com/multimediaplayer.aspx?multimediaid=10528477 , so I'm getting a little more convinced that my guess about pia following vasculature to ventricles for choriod may be correct. Respect. UnderEducatedGeezer (talk) 11:24, 2 January 2020 (UTC)[reply]

At this date I'm of the opinion that I've been thinking about the source of pia in the choroid plexus wrongly, wondering how the pia gets from the lining of the brain, at the 'outside' of the brain, into the ventricles, in the 'inside' of the brain. The simple explanation may be that it gets there in utero, as a part of embryonic development, when at some point pia material is available to the ventricles because everything is closer together (1 cell, 2, 4,8,16, etc). UnderEducatedGeezer (talk) 09:21, 18 August 2020 (UTC)[reply]

Hello UnderEducatedGeezer you are right, as regards forming in the development of the ventricles - I have looked at this before and have not yet entered up anything for want of better clarity and good ref.--Iztwoz (talk) 10:06, 18 August 2020 (UTC)[reply]

Hi Iztwoz! Every once in a while (currently as it happens), I'm still looking into this, and finding a good explanation of the structure of the CP very hard to come by! So I'm sort of glad that someone of your caliber may also be having difficulty finding really good sources of info! One candidate might be: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818536/ , although I find its first picture, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818536/figure/F1/?report=objectonly confusing, as it seems to show CP in the roof of the lateral ventricles, which is not how most that I've seen show it (ie, on the floor). I'm also looking to see/understand its 3D structure, and how it attaches along its length(s) to the ventricle walls. And did you see my next post under this section? Looks to me that there's a completely erroneous statement in the article? UnderEducatedGeezer (talk) 03:21, 19 August 2020 (UTC)[reply]

Have found this to be very good - ^[1] best --Iztwoz (talk) 06:37, 19 August 2020 (UTC)[reply]

Thanks, Iztwoz, but so far have only been able to have access to read the Key Points and Abstract. UnderEducatedGeezer (talk) 12:01, 19 August 2020 (UTC)[reply]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629451/

Ah, thanks, Iztwoz, got it & bookmarked it! UnderEducatedGeezer (talk) 12:16, 31 August 2020 (UTC)[reply]

References

^ Lun, MP; Monuki, ES; Lehtinen, MK (August 2015). "Development and functions of the choroid plexus-cerebrospinal fluid system". Nature reviews. Neuroscience. 16 (8): 445–57. doi:10.1038/nrn3921. PMID 26174708.

Location of CP in lateral ventricles currently wrong

Currently in this article, in Structure, & Location, there is a statement, "In the lateral ventricles, it is only present in the inferior horn.[2]". This must be wrong. It is present in the floor of the superior horn of the lateral ventricles at least at the foramen of monro, in the walls of the foramen, and on the roof of the third ventricle, as far as I understand. UnderEducatedGeezer (talk) 09:57, 18 August 2020 (UTC)[reply]

Never mind, I see it's been fixed. :) UnderEducatedGeezer (talk) 12:11, 31 August 2020 (UTC)[reply]

" is a plexus of cells that arises from the tela choroidea in each of the ventricles of the brain"

... this phrase is kind of misleading, there are two choroid plexus, one in the roof of the four ventricle (posterior or inferior choroid plexus) and one that develops in the third ventricle (anterior or superior choroid plexus) but the telencephalon gets so convoluted during development that the plexus spreads over the lateral ventricles too. That should be clarified because it reads as there are two more choroid plexus arising from the lateral ventricles, and that is not the case. Lmalena (talk) 19:54, 3 September 2021 (UTC)[reply]

CSF-brain barrier in embryo and adult

On my talk page, IP 178.233.42.242 said: "In reply to your response including the sentence "Your edit was overly technical, and the previous version was accurate, according to the source (caption to Fig. 1f): There is a CSF-brain barrier at the level of the pia mater, but only in the embryo.", I have to tell you without any intention of disrespectfulness that the previous version was not accurate. The barrier in question is not at the level of pia mater, and there is no part of the article where that level has been referred to as "the level of pia mater". There was a brief discussion on the IP's talk page, here.

The edit revert and summary for the article were here, posted now for assessment, discussion, and consensus. Zefr (talk) 17:01, 12 December 2021 (UTC)[reply]

First image mislabeled

I think I have noticed some oddities in the first image of this page, titled "Slide7oo.PNG". First the septum pellucidum is labeled "septum lucidum". I could not find any evidence for this as an alternative name, but correct me if I am wrong! Second, I think the left and right hemisphere labels are switched. Based on the location of the pons and the way the lateral ventricle diverges, I think we are looking at the brain from the anterior side. Because medical images are always labeled from the subject's/patient's perspective, if this is the anterior side, the "left hemisphere" would actually be the right hemisphere. I looked at the rest of the labels and they look okay, but I am not 100% about that.

Is there a way to edit the image? or would it need to be replaced? I am new to the editing side of Wiki, so if it is something I can fix let me know! I thought I had better add a topic here and not risk messing something up by accident. I will do some research and see how I can fix it when I get a chance.

Thanks, RubyFjord (talk) 05:18, 29 September 2023 (UTC)[reply]

I agree that image could potentially confuse users, so have replaced it with one of the fourth ventricle, leaving the lateral ventricle image for perspective. Zefr (talk) 15:19, 29 September 2023 (UTC)[reply]

Thank you! RubyFjord (talk) 15:32, 29 September 2023 (UTC)[reply]

[1] Lun, MP; Monuki, ES; Lehtinen, MK (August 2015). "Development and functions of the choroid plexus-cerebrospinal fluid system". Nature reviews. Neuroscience. 16 (8): 445–57. doi:10.1038/nrn3921. PMID 26174708.

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