Talk:CD20
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Untitled
[edit]External link - In German... —Preceding unsigned comment added by 124.169.69.120 (talk) 06:55, 10 October 2008 (UTC)
where is it first seen?
[edit]how is it on pre-pre B-cells and not on pro B-cells. Arent' those the same thing?
clinincal significance
[edit]Could this section list other diseases that anti-CD20 agents may treat ? Rod57 (talk) 05:00, 19 February 2010 (UTC)
Erroneous theoretical structure of CD20
[edit]CD20 is a member of the Membrane-spanning 4A family of genes (MS4A). It consists of four transmembrane helical segments (UniProtKB/Swiss-Prot entry P11836). As thus, the image in the wikipedia page http://wiki.riteme.site/wiki/MS4A1, corresponding to a theoretical model (PDB entry 1S8B) and composed essentially of 8 transmembrane parallel "curly" strands is completely wrong and misleading! Compare to the high-resolution crystallographic structure of the GA101 anti-CD20 antibody complexed to the CD20 antigen. Therefore, that image should be ignored and for all practical purposes deleted from the article. 193.52.23.133 (talk) 16:08, 29 August 2012 (UTC)CMaroun, France
Copyright problem removed
[edit]
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contradicting
[edit]the beggining stated 'expressed on the surface of all B-cells beginning at the pro-B phase' and then under Expressions it says ' expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through memory cells, but not on either early pro-B cells'
which one is it?? 195.194.4.65 (talk) 10:54, 15 July 2023 (UTC)
Structural rendering of CD20 is still wrong
[edit]This was noted previously, as far back as 2012. It is a dimeric membrane protein with each subunit containing 4 transmembrane helices. There is no experimentally determined structure of C20 on its own, but multiple structures done by cryo-electron microscopy of the full length CD20 in complex with Rituximab Fab. Here is a link for one such structure. https://www.rcsb.org/structure/6Y90. All the structural links given in the article should get similarly updated. The present links are for structures of CD20 peptide epitopes in complex with anti-CD20 antibody Fab's. RepSeattle (talk) 19:26, 20 September 2023 (UTC)