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Approval date

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Is this medicine out yet? I am confused about the June 20th date given. Was it approved by the FDA or put on the market then?

It was approved by the FDA on 2007-06-20. I added a reference. Depending on the manufacturer's perceived potential demand will depend on when it will actually be available. MeekMark (talk) 19:42, 21 January 2008 (UTC)[reply]

More details

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There is public confusion as to whether Nuvigil is a generic of Provigil, or an improvement on Provigil. As of September 10, 2010, the F.D.A. reports that Nuvigil and Provigil were approved as different drugs. The FDA does not consider them interchangeable. However, United Health Care is now refusing to cover Provigil in some if not all of its health plans, in favor of Nuvigil. Letters sent out from United Health Care in July stated that Provigil prescriptions would AUTOMATICALLY be filled with Nuvigil. By September, 2010, that position had changed, when United apparently realized they are different medications and require different prescriptions under law. A pharmacist at United Health Care comparred Nuvigil and Provigil to differing brands of Ibuprofin, yet representatives of Cephalon on their information line state the two medications are chemically different. Provigil is a combination of R and S isomers of modafinil. Nuvigil uses only the R isomer, with the hope that it will have longer lasting effects in the body. However, Cephalon states that it has no comparative test data on Nuvigil and Provigil, either on efficacy or patient tolerance. Both substances carry a risk of dependency and producing mania. Provigil has been well tolerated by millions of patients for years. Without the necessary comparative data, it is uncertain at this time whether Nuvigil will be as well tolerated, even though both medications have the same active ingredient. It would seem premature and unwise for a blanket substitution of Nuvigil for Provigil without comparative testing. —Preceding unsigned comment added by 69.254.131.245 (talk) 03:59, 11 September 2010 (UTC)[reply]

this article needs more details, like side effects, time of peak levels, differences with modafinil, etc. most of this information can be found here: http://www.rxlist.com/nuvigil-drug.htm but i am not a good writer, so could someone please add this information? the article seems bare, even though there is a ton of information about admofafinil out there. sorry about not logging in by the way. 71.255.166.119 (talk) 04:37, 24 November 2009 (UTC)[reply]

12:09, 21 April 2011 (UTC)ProfMad12:09, 21 April 2011 (UTC)

(-)-R-Modafinil

If the pharmokinetic data is correct from NUVIGIL.COM, R-Modafinil, reaches a plasma concentration (CMax.) ~1.8 x that of Modafinil, after 7 days, due to its longer t1/2.

Therefore, it is not twice the potency of Modafinil, given as a single dose (i.e. L-Modafinil, is a (50% w/w) inactive component of Modafinil), rather R- Modafinil plasma concentrations increase (167-180% cf. L-& R- Modafinil} over 7 consecutive doses.

Whether or not this affects sleep patterns more than Modafinil, is something not yet well published (to my knowledge).

This possibility, though not creating two separate drugs, may be similarly compared to short, medium & long acting benzodiazepines, and their differing applications, (i.e Modafinil may be better for jet lag, Armodafinil possibly for sleep apnoea).

12:09, 21 April 2011 (UTC)ProfMad12:09, 21 April 2011 (UTC) — Preceding unsigned comment added by Profmad (talk • contribs)

Sun generic: Waklert

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Sun Pharma has apparently for a while now manufactured its own armodafinil as well as its existing modafinil generics; but this isn't mentioned. I'm particularly confused because as far as I can tell, armodafinil should not be covered under the Indian loophole that lets Sun manufacture modafinil.

Also, two armodafinil studies: http://www.4nrx.co.uk/Waklert.pdf --Gwern (contribs) 17:40 28 October 2011 (GMT)

No longer available references

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Reference #4, Cephalon - Pipeline is giving a 404 error right now. If this continues, a new source will need to be found. Archdiamond (talk) 17:11, 7 November 2012 (UTC)[reply]

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These links are current as of 2010. These were updated for the medication 12/2022. These ought to be changed to reflect current drug information. 24.181.125.234 (talk) 17:55, 15 February 2023 (UTC)[reply]

Change: medical uses

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Under Medical Uses, this sentence appears: "however in the United States, sleep prevention medications such as Dalmane (Flurazepam), Provigil (Modafinil), and Nuvigil (Armodafinil) are not approved by the FAA for civilian controllers or pilots." Dalmane is NOT a sleep prevention medication. In fact, it is prescribed as a sleep-promoting medication. 150.148.14.129 (talk) 19:09, 19 November 2021 (UTC)[reply]

Outdated medication guide and prescribing information reference PDFs

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The information at the bottom of the page citing medication guide and PI are old and outdated. They are from 2010. These were revised in 12/2022. I added a new link, but it was removed by CV9933 user. I suggest adding the correct and updated information to this page. Furthermore, medication guide and prescribing information cited from an archived internet page, as opposed to the actual pharmaceutical manufacturer's site leads to only outdated and inaccurate information. Please add the appropriate PDF instead like I did before someone deleted it. https://www.nuvigil.com/globalassets/nuvigil-consumer/prescribinginformation.pdf 24.181.125.234 (talk) 17:54, 15 February 2023 (UTC)[reply]

Request to change addiction and dependence liability status to true state

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hi I have just finished school in chemical dependency and in my multiple drug classes I've learned that the addiction and dependence liability status of armodafinil is not low. it's moderate. at best. so I requested we are here to give real and true information so let's please keeps this at the true state of this medication. thank you. NW49ERSFAN24 (talk) 00:47, 26 December 2024 (UTC)[reply]

Citing a WP:MEDRS is the only possible way to get your idea implemented. DMacks (talk) 10:29, 26 December 2024 (UTC)[reply]
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