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Steroid-transporting ATPase

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Steroid-transporting ATPase
Identifiers
EC no.3.6.3.45
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
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Steroid-transporting ATPase (EC 3.6.3.45, pleiotropic-drug-resistance protein, PDR protein) is an enzyme with systematic name ATP phosphohydrolase (steroid-exporting).[1][2][3] This enzyme catalyses the following chemical reaction

ATP + H2O + steroidin ADP + phosphate + steroidout

This enzyme has two similar ATP-binding domains.

References

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  1. ^ Prasad R, De Wergifosse P, Goffeau A, Balzi E (March 1995). "Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals". Current Genetics. 27 (4): 320–9. doi:10.1007/BF00352101. PMID 7614555.
  2. ^ Nagao K, Taguchi Y, Arioka M, Kadokura H, Takatsuki A, Yoda K, Yamasaki M (March 1995). "bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily". Journal of Bacteriology. 177 (6): 1536–43. PMC 176770. PMID 7883711.
  3. ^ Mahé Y, Lemoine Y, Kuchler K (October 1996). "The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo". The Journal of Biological Chemistry. 271 (41): 25167–72. doi:10.1074/jbc.271.41.25167. PMID 8810273.
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