Racefemine
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| Trade names | Dysmalgine, Evalgin |
| Other names | N-(1-Methyl-2-phenoxyethyl)amphetamine; CB-3697; Racephemine |
| Drug class | β-Adrenergic receptor agonist; Tocolytic |
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| CAS Number | |
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| Chemical and physical data | |
| Formula | C18H23NO |
| Molar mass | 269.388 g·mol−1 |
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Racefemine (INN), sold under the brand names Dysmalgine and Evalgin, is a uterine spasmolytic and muscle relaxant of the amphetamine family.[1][2][3][4][5] It is the racemic threo form of dextrofemine.[1][3] The drug acts as a β-adrenergic receptor agonist and sympathomimetic.[6] It appears to no longer be marketed.[7][8] Other tocolytics with similar chemical structures as phenethylamines or amphetamines include bedoradrine, buphenine, fenoterol, hexoprenaline, isoxsuprine, ritodrine, and terbutaline.[6][1]
References
[edit]- ^ a b c Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. pp. 804, others. ISBN 978-1-4757-2085-3. Retrieved 9 October 2024.
- ^ Morton IK, Hall JM (2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Netherlands. p. 244. ISBN 978-94-011-4439-1. Retrieved 9 October 2024.
- ^ a b Martindale W, Reynolds JE (1993). The Extra Pharmacopoeia. Martindale Series. Pharmaceutical Press. p. 1408. ISBN 978-0-85369-300-0. Retrieved 9 October 2024.
Racefemine fumarate has been used as a uterine relaxant. The dextrorotatory isomer, dextrofemine, has been used intravenously.
- ^ Kleemann A, Engel J (2001). Pharmaceutical Substances: Syntheses, Patents, Applications. Thieme. p. 1779. ISBN 978-1-58890-031-9. Retrieved 9 October 2024.
- ^ Milne GW (2018). Drugs: Synonyms and Properties. Routledge Revivals. Taylor & Francis. p. 451. ISBN 978-1-351-78990-5. Retrieved 9 October 2024.
- ^ a b Sas M, Kovács L (1981). "Systemic Pharmacology of Adrenergic Activators and Inhibitors: Effects on the Genital System". Handbook of Experimental Pharmacology. Vol. 54 / 2. Berlin, Heidelberg: Springer Berlin Heidelberg. pp. 213–242. doi:10.1007/978-3-642-67584-3_5. ISBN 978-3-642-67586-7. ISSN 0171-2004.
- ^ Muller NF, Dessing RP (1997). European Drug Index: European Drug Registrations (in Danish) (Fourth ed.). Taylor & Francis. p. 412. ISBN 978-1-351-44947-2. Retrieved 9 October 2024.
- ^ Schweizerischer Apotheker-Verein (2000). Index Nominum 2000: International Drug Directory. Medpharm Scientific Publishers. ISBN 978-3-88763-075-1. Retrieved 9 October 2024.