Protein-fructosamine 3-kinase
Appearance
Protein-fructosamine 3-kinase | |||
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Identifiers | |||
EC no. | 2.7.1.171 | ||
Databases | |||
IntEnz | IntEnz view | ||
BRENDA | BRENDA entry | ||
ExPASy | NiceZyme view | ||
KEGG | KEGG entry | ||
MetaCyc | metabolic pathway | ||
PRIAM | profile | ||
PDB structures | RCSB PDB PDBe PDBsum | ||
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Protein-fructosamine 3-kinase (EC 2.7.1.171, FN3K, fructosamine 3-kinase) is an enzyme with systematic name ATP:(protein)-N6-D-fructosyl-L-lysine 3-phosphotransferase.[1][2] This enzyme catalyses the following chemical reaction
- ATP + [protein]-N6-D-fructosyl-L-lysine ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
Nonenzymatic glycation is a factor in the pathogenesis of diabetes.
References
[edit]- ^ Szwergold BS, Howell S, Beisswenger PJ (September 2001). "Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo". Diabetes. 50 (9): 2139–47. doi:10.2337/diabetes.50.9.2139. PMID 11522682.
- ^ Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E (October 2000). "Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase". Diabetes. 49 (10): 1627–34. doi:10.2337/diabetes.49.10.1627. PMID 11016445.
External links
[edit]- Protein-fructosamine+3-kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)