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Progesterone monooxygenase

From Wikipedia, the free encyclopedia
progesterone monooxygenase
Identifiers
EC no.1.14.99.4
CAS no.37256-85-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a progesterone monooxygenase (EC 1.14.99.4) is an enzyme that catalyzes the chemical reaction

progesterone + AH2 + O2 testosterone acetate + A + H2O

The 3 substrates of this enzyme are progesterone, AH2, and O2, whereas its 3 products are testosterone acetate, A, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O miscellaneous.[clarification needed] The systematic name of this enzyme class is progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating). This enzyme is also called progesterone hydroxylase.

References

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  • Rahm MA, Sih CJ (August 1966). "Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain". The Journal of Biological Chemistry. 241 (15): 3615–23. doi:10.1016/S0021-9258(18)99875-3. PMID 5950688.