Portal:Spaceflight/On This Day/27 September
- 1962 - A Vostok-2 launches the Kosmos 9 satellite.
- 1963 - A Scout X-2B fails to launch the OPS 1610 satellite.
- 1967 - A Kosmos-3M fails to launch an unknown satellite.
- 1967 - A Proton-K fails to launch an unknown satellite.
- 1973 - A Soyuz launches the manned Soyuz 12 mission.
- 1973 - A Titan 24B launches a KH-8 satellite.
- 1975 - A Diamant launches the D-2B satellite.
- 1984 - A Soyuz-U launches the Kosmos 1600 satellite.
- 1984 - A Kosmos-3M launches the Kosmos 1601 satellite.
- 1985 - A Proton-K launches the Kosmos 1686 spacecraft to Salyut 7.
- 1989 - A Molniya-M launches a Molniya-1 satellite.
- 1989 - A Tsyklon-2 launches the Kosmos 2046 satellite.
- 1990 - A Soyuz-U2 launches the Progress M-5 spacecraft to resupply Mir.
- 1994 - A Kosmos-3M launches the Kosmos 2292 satellite.
- 1997 - A Delta II launches five Iridium satellites.
- 2003 - A Kosmos-3M launches the STSat-1, DMC-2 and Mozhazets satellites.
- 2003 - An Ariane 5 launches the Insat 3E and e-Bird satellites.
- 2004 - A Long March 2D launches the FSW-20 satellite.
- 2007 - A Delta IIH launches the Dawn probe.
- 2008 - Shenzhou 7 crewmembers Zhai Zhigang and Liu Boming perform China's first EVA.
- 2011 - A Minotaur IV launches the TacSat-4 satellite.
- 2022 - DART crashes on asteroid Dimorphos