Phosphatidylserine decarboxylase

phosphatidylserine decarboxylase
Identifiers
EC no.	4.1.1.65
CAS no.	9054-78-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Phosphatidylserine decarboxylase
Identifiers
Symbol	PSD
Pfam	PF02666
InterPro	IPR003817
Membranome	595
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The enzyme phosphatidylserine decarboxylase (EC 4.1.1.65) catalyzes the chemical reaction

phosphatidyl-L-serine $\rightleftharpoons$ phosphatidylethanolamine + CO₂

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming). Other names in common use include PS decarboxylase, and phosphatidyl-L-serine carboxy-lyase. This enzyme participates in glycine, serine and threonine metabolism, and glycerophospholipid metabolism. It has two cofactors: pyridoxal phosphate, and Pyruvate.

References

• KANFER J, KENNEDY EP (1964). "Metabolism and Function of Bacterial Lipids. Ii. Biosynthesis of Phospholipids in Escherichia Coli". J. Biol. Chem. 239 (6): 1720–6. doi:10.1016/S0021-9258(18)91247-0. PMID 14213340.
• Satre M, Kennedy EP (1978). "Identification of bound pyruvate essential for the activity of phosphatidylserine decarboxylase of Escherichia coli". J. Biol. Chem. 253 (2): 479–83. doi:10.1016/S0021-9258(17)38234-0. PMID 338609.