O-2390
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Formula | C15H19Cl2NO |
Molar mass | 300.22 g·mol−1 |
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O-2390 (3,4-Dichloro-alpha-PVP, DCPVP) is a recreational designer drug from the substituted cathinone family, which acts as a potent inhibitor of dopamine and noradrenaline reuptake in vitro, with weaker but still significant inhibition of serotonin reuptake.[1][2][3][4]
See also
[edit]- 3F-PVP
- 4F-PVP
- 4Cl-PVP
- 3,4-DCMP
- Chlorosipentramine
- Cilobamine
- Dichloropane
- LR-5182
- MDPV
- MFPVP
- Naphyrone
- Sertraline
- TH-PVP
References
[edit]- ^ Meltzer PC, Butler D, Deschamps JR, Madras BK (February 2006). "1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors". Journal of Medicinal Chemistry. 49 (4): 1420–1432. doi:10.1021/jm050797a. PMC 2602954. PMID 16480278.
- ^ Kolanos R, Sakloth F, Jain AD, Partilla JS, Baumann MH, Glennon RA (October 2015). "Structural Modification of the Designer Stimulant α-Pyrrolidinovalerophenone (α-PVP) Influences Potency at Dopamine Transporters". ACS Chemical Neuroscience. 6 (10): 1726–1731. doi:10.1021/acschemneuro.5b00160. PMC 5349767. PMID 26217965.
- ^ Glennon RA, Young R (September 2016). "Neurobiology of 3,4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinovalerophenone (α-PVP)". Brain Research Bulletin. 126 (Pt 1): 111–126. doi:10.1016/j.brainresbull.2016.04.011. PMC 5817884. PMID 27142261.
- ^ Yadav-Samudrala BJ, Eltit JM, Glennon RA (September 2019). "Synthetic Cathinone Analogues Structurally Related to the Central Stimulant Methylphenidate as Dopamine Reuptake Inhibitors". ACS Chemical Neuroscience. 10 (9): 4043–4050. doi:10.1021/acschemneuro.9b00284. PMID 31369229. S2CID 199380459.