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N-isopropylammelide isopropylaminohydrolase

From Wikipedia, the free encyclopedia
N-isopropylammelide isopropylaminohydrolase
Identifiers
EC no.3.5.99.4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a N-isopropylammelide isopropylaminohydrolase (EC 3.5.99.4) is an enzyme that catalyzes the chemical reaction

N-isopropylammelide + H2O cyanuric acid + isopropylamine

Thus, the two substrates of this enzyme are N-isopropylammelide and H2O, whereas its two products are cyanuric acid and isopropylamine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in compounds that have not been otherwise categorized within EC number 3.5. The systematic name of this enzyme class is N-isopropylammelide isopropylaminohydrolase. This enzyme is also called AtzC. This enzyme participates in atrazine degradation.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2QT3.

References

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  • Sadowsky MJ, Tong Z, de Souza M, Wackett LP (1998). "AtzC is a new member of the amidohydrolase protein superfamily and is homologous to other atrazine-metabolizing enzymes". J. Bacteriol. 180 (1): 152–8. doi:10.1128/JB.180.1.152-158.1998. PMC 106861. PMID 9422605.