Microsomal glutathione S-transferase 1

MGST1
Identifiers
Aliases	MGST1, GST12, MGST, MGST-I, microsomal glutathione S-transferase 1
External IDs	OMIM: 138330; MGI: 1913850; HomoloGene: 10544; GeneCards: MGST1; OMA:MGST1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p12.3 Start 16,347,142 bp End 16,609,259 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 G1 Start 138,117,314 bp End 138,133,753 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex right lobe of liver mucosa of ileum adipose tissue abdominal fat subcutaneous adipose tissue pericardium Top expressed in left lobe of liver tunica adventitia of aorta transitional epithelium of urinary bladder right lung lobe granulocyte subcutaneous adipose tissue white adipose tissue intercostal muscle brown adipose tissue nose More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity identical protein binding glutathione binding protein homodimerization activity glutathione peroxidase activity protein binding glutathione transferase activity prostaglandin-E synthase activity Cellular component integral component of membrane mitochondrion nucleus peroxisomal membrane apical part of cell intracellular membrane-bounded organelle membrane endoplasmic reticulum endoplasmic reticulum membrane mitochondrial outer membrane plasma membrane azurophil granule membrane Biological process xenobiotic metabolic process response to lipopolysaccharide protein homotrimerization Leydig cell differentiation cellular response to lipid hydroperoxide glutathione derivative biosynthetic process response to organonitrogen compound cellular oxidant detoxification neutrophil degranulation prostaglandin biosynthetic process glutathione metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4257 56615 Ensembl ENSG00000008394 ENSMUSG00000008540 UniProt P10620 Q91VS7 RefSeq (mRNA) NM_001260511 NM_001260512 NM_001267598 NM_020300 NM_145764 NM_145791 NM_145792 NM_019946 NM_001347489 NM_001361308 NM_001361309 NM_001361307 RefSeq (protein) NP_001247440 NP_001247441 NP_001254527 NP_064696 NP_665707 NP_665734 NP_665735 NP_001334418 NP_064330 NP_001348237 NP_001348238 NP_001348236 Location (UCSC) Chr 12: 16.35 – 16.61 Mb Chr 6: 138.12 – 138.13 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Microsomal glutathione S-transferase 1 is an enzyme that in humans is encoded by the MGST1 gene.

Function

The MAPEG family (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Four transcript variants of this gene encode one protein isoform.

Further reading

• Jakobsson PJ, Morgenstern R, Mancini J (2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily". Am. J. Respir. Crit. Care Med. 161 (2 Pt 2): S20–4. doi:10.1164/ajrccm.161.supplement_1.ltta-5. PMID 10673221.
• Cholon A, Giaccia AJ, Lewis AD (1992). "What role do glutathione S-transferases play in the cellular response to ionizing radiation?". Int. J. Radiat. Oncol. Biol. Phys. 22 (4): 759–63. doi:10.1016/0360-3016(92)90519-N. PMID 1544849.
• DeJong JL, Mohandas T, Tu CP (1990). "The gene for the microsomal glutathione S-transferase is on human chromosome 12". Genomics. 6 (2): 379–82. doi:10.1016/0888-7543(90)90580-N. PMID 2307478.
• DeJong JL, Morgenstern R, Jörnvall H (1988). "Gene expression of rat and human microsomal glutathione S-transferases". J. Biol. Chem. 263 (17): 8430–6. doi:10.1016/S0021-9258(18)68495-9. PMID 3372534.
• Adams MD, Kerlavage AR, Fleischmann RD (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Söderström M, Morgenstern R, Hammarström S (1995). "Protein-protein interaction affinity chromatography of leukotriene C4 synthase". Protein Expr. Purif. 6 (3): 352–6. doi:10.1006/prep.1995.1046. PMID 7663172.
• Kelner MJ, Stokely MN, Stovall NE, Montoya MA (1997). "Structural organization of the human microsomal glutathione S-transferase gene (GST12)". Genomics. 36 (1): 100–3. doi:10.1006/geno.1996.0429. PMID 8812420.
• Estonius M, Forsberg L, Danielsson O (1999). "Distribution of microsomal glutathione transferase 1 in mammalian tissues. A predominant alternate first exon in human tissues". Eur. J. Biochem. 260 (2): 409–13. doi:10.1046/j.1432-1327.1999.00165.x. PMID 10095775.
• Lee SH, DeJong J (1999). "Microsomal GST-I: genomic organization, expression, and alternative splicing of the human gene". Biochim. Biophys. Acta. 1446 (3): 389–96. doi:10.1016/S0167-4781(99)00112-8. PMID 10524215.
• Kelner MJ, Bagnell RD, Montoya MA (2000). "Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p13.1-13.2. Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress". J. Biol. Chem. 275 (17): 13000–6. doi:10.1074/jbc.275.17.13000. PMID 10777602.
• Surapureddi S, Svartz J, Magnusson KE (2000). "Colocalization of leukotriene C synthase and microsomal glutathione S-transferase elucidated by indirect immunofluorescence analysis". FEBS Lett. 480 (2–3): 239–43. Bibcode:2000FEBSL.480..239S. doi:10.1016/S0014-5793(00)01885-8. PMID 11034337. S2CID 36611943.
• Iida A, Saito S, Sekine A (2001). "Catalog of 46 single-nucleotide polymorphisms (SNPs) in the microsomal glutathione S-transferase 1 (MGST1) gene". J. Hum. Genet. 46 (10): 590–4. doi:10.1007/s100380170026. PMID 11587073.
• To-Figueras J, Gené M, Gómez-Catalán J (2003). "Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk". Cancer Lett. 187 (1–2): 95–101. doi:10.1016/S0304-3835(02)00406-8. PMID 12359356.
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ekström L, Lyrenäs L, Jakobsson PJ (2003). "Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3". Biochim. Biophys. Acta. 1627 (2–3): 79–84. doi:10.1016/S0167-4781(03)00077-0. PMID 12818425.
• Lengqvist J, Svensson R, Evergren E (2004). "Observation of an intact noncovalent homotrimer of detergent-solubilized rat microsomal glutathione transferase-1 by electrospray mass spectrometry". J. Biol. Chem. 279 (14): 13311–6. doi:10.1074/jbc.M310958200. PMID 14726533.
• Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.