L-arabinose isomerase
Appearance
L-arabinose isomerase | |||
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Identifiers | |||
EC no. | 5.3.1.4 | ||
CAS no. | 9023-80-7 | ||
Databases | |||
IntEnz | IntEnz view | ||
BRENDA | BRENDA entry | ||
ExPASy | NiceZyme view | ||
KEGG | KEGG entry | ||
MetaCyc | metabolic pathway | ||
PRIAM | profile | ||
PDB structures | RCSB PDB PDBe PDBsum | ||
Gene Ontology | AmiGO / QuickGO | ||
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Arabinose isomerase | |||
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Identifiers | |||
Symbol | Arabinose_Isome | ||
Pfam | PF02610 | ||
InterPro | IPR003762 | ||
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In enzymology, a L-arabinose isomerase (EC 5.3.1.4) is an enzyme that catalyzes the chemical reaction
- L-arabinose L-ribulose
Hence, this enzyme has one substrate, L-arabinose, and one product, L-ribulose.
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is L-arabinose aldose-ketose-isomerase. This enzyme participates in pentose and glucuronate interconversions.
This enzyme catalyses the conversion of L-arabinose to L-ribulose as the first step in the pathway of L-arabinose utilization as a carbon source.[1]
Structural studies
[edit]As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2AJT and 2HXG.
References
[edit]- ^ Sa-Nogueira I, Nogueira TV, Soares S, de Lencastre H (March 1997). "The Bacillus subtilis L-arabinose (ara) operon: nucleotide sequence, genetic organization and expression". Microbiology. 143 (3): 957–69. doi:10.1099/00221287-143-3-957. PMID 9084180.
Further reading
[edit]- HEATH EC, HORECKER BL, SMYRNIOTIS PZ, TAKAGI Y (1958). "Pentose fermentation by Lactobacillus plantarum. II. L-arabinose isomerase". J. Biol. Chem. 231 (2): 1031–7. doi:10.1016/S0021-9258(18)70464-X. PMID 13539034.
- Nakamatu T, Yamanaka K (1969). "Crystallization and properties of L-arabinose isomerase from Lactobacillus gayonii". Biochim. Biophys. Acta. 178 (1): 156–65. doi:10.1016/0005-2744(69)90142-9. PMID 5773448.