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Hydroxymethylglutaryl-CoA hydrolase

From Wikipedia, the free encyclopedia
hydroxymethylglutaryl-CoA hydrolase
Identifiers
EC no.3.1.2.5
CAS no.9025-89-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme hydroxymethylglutaryl-CoA hydrolase (EC 3.1.2.5) catalyzes the reaction

S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is S-(2-hydroxyacyl)glutathione hydrolase. Other names in common use include β-hydroxy-beta-methylglutaryl coenzyme A hydrolase, β-hydroxy-β-methylglutaryl coenzyme A deacylase, hydroxymethylglutaryl coenzyme A hydrolase, hydroxymethylglutaryl coenzyme A deacylase, and 3-hydroxy-3-methylglutaryl-CoA hydrolase.

References

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  • Dekker EE, Schlesinger MJ, Coon MJ (1958). "β-Hydroxy-β-methylglutaryl coenzyme A deacylase". J. Biol. Chem. 233 (2): 434–8. PMID 13563516.