Fragilysin
| Fragilysin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.24.74 | ||||||||
| CAS no. | 188596-63-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Fragilysin (EC 3.4.24.74, Bacteroides fragilis (entero)toxin) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Broad proteolytic specificity, bonds hydrolysed including -Gly-Leu-, -Met-Leu-, -Phe-Leu-, -Cys-Leu-, Leu-Gly
It is thought to be a cause of diarrhoea in animals and humans.
References
[edit]- ^ Moncrief JS, Obiso R, Barroso LA, Kling JJ, Wright RL, Van Tassell RL, Lyerly DM, Wilkins TD (January 1995). "The enterotoxin of Bacteroides fragilis is a metalloprotease". Infection and Immunity. 63 (1): 175–81. PMC 172975. PMID 7806355.
- ^ Obiso RJ, Lyerly DM, Van Tassell RL, Wilkins TD (October 1995). "Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo". Infection and Immunity. 63 (10): 3820–6. PMC 173537. PMID 7558286.
- ^ Donelli G, Fabbri A, Fiorentini C (January 1996). "Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells". Infection and Immunity. 64 (1): 113–9. PMC 173735. PMID 8557328.
- ^ Koshy SS, Montrose MH, Sears CL (December 1996). "Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis". Infection and Immunity. 64 (12): 5022–8. PMC 174483. PMID 8945541.
- ^ Kling JJ, Wright RL, Moncrief JS, Wilkins TD (January 1997). "Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis". FEMS Microbiology Letters. 146 (2): 279–84. doi:10.1016/s0378-1097(96)00488-0. PMID 9011050.
External links
[edit]- Fragilysin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
