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Protein found in humans
Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene .[ 5] [ 6]
EAAT4 is expressed predominantly in the cerebellum , has high affinity for the excitatory amino acids L-aspartate and L-glutamate . When stimulated by these amino acids, EAAT4 conducts chloride ions.[ 6]
Deng X, Shibata H, Takeuchi N, et al. (2007). "Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet . 144B (3): 271–8. doi :10.1002/ajmg.b.30351 . PMID 17221839 . S2CID 42347750 .
Need AC, Keefe RS, Ge D, et al. (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis" . Eur. J. Hum. Genet . 17 (7): 946–57. doi :10.1038/ejhg.2008.264 . PMC 2986499 . PMID 19156168 .
Poulsen MV, Vandenberg RJ (2001). "Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4" . J. Physiol . 534 (Pt 1): 159–67. doi :10.1111/j.1469-7793.2001.00159.x . PMC 2278676 . PMID 11432999 .
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell . 122 (6): 957–68. doi :10.1016/j.cell.2005.08.029 . hdl :11858/00-001M-0000-0010-8592-0 . PMID 16169070 . S2CID 8235923 .
Jackson M, Song W, Liu MY, et al. (2001). "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins" . Nature . 410 (6824): 89–93. doi :10.1038/35065091 . PMID 11242047 . S2CID 4381210 .
Rajamanickam J, Palmada M, Lang F, Boehmer C (2007). "EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase" . J. Neurochem . 102 (3): 858–66. doi :10.1111/j.1471-4159.2007.04585.x . PMID 17442044 . S2CID 30779935 .
Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment" . Am. J. Med. Genet. B Neuropsychiatr. Genet . 150B (6): 808–16. doi :10.1002/ajmg.b.30902 . PMID 19086053 . S2CID 44524739 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
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By group
SLC1–10
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SLC11–20
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SLC21–30
(21): (22): (23): (24): (25): (26): (27): (28): (29): (30):
SLC31–40
(31): (32): (33): (34): (35): (36): (37): (38): (39): (40):
SLC41–48
(41): (42): (43): (44): (45): (46): (47): (48):
Transporter
EAATs Tooltip Excitatory amino acid transporters vGluTs Tooltip Vesicular glutamate transporters
Enzyme
GAH Tooltip Glutamine aminohydrolase (glutaminase) AST Tooltip Aspartate aminotransferase ALT Tooltip Alanine aminotransferase GDH Tooltip Glutamate dehydrogenase GS Tooltip Glutamine synthetase GAD Tooltip Glutamate decarboxylase