Sodium-dependent neutral amino acid transporter B(0)AT2

SLC6A15
Identifiers
Aliases	SLC6A15, NTT73, SBAT1, V7-3, hv7-3, solute carrier family 6 member 15
External IDs	OMIM: 607971; MGI: 2143484; HomoloGene: 18163; GeneCards: SLC6A15; OMA:SLC6A15 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	84,913,629 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	103,255,238 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; prefrontal cortex; ; testicle; ; cerebellar hemisphere; ; Brodmann area 9; ; right hemisphere of cerebellum; ; middle temporal gyrus; ; Brodmann area 23; ; ganglionic eminence; ; primary visual cortex;
	Top expressed in
	saccule; ; barrel cortex; ; ciliary body; ; iris; ; hippocampus proper; ; dentate gyrus; ; Cerebellum; ; dentate gyrus of hippocampal formation granule cell; ; secondary oocyte; ; Epithelium of choroid plexus;
	More reference expression data
	n/a
Gene ontology
Molecular function	neurotransmitter:sodium symporter activity; neurotransmitter transmembrane transporter activity; symporter activity; proline:sodium symporter activity; amino acid transmembrane transporter activity;
Cellular component	plasma membrane; membrane; integral component of plasma membrane; integral component of membrane;
Biological process	sodium ion transport; proline transport; neutral amino acid transport; neurotransmitter transport; amino acid transport; ion transport; leucine transport; transmembrane transport; amino acid transmembrane transport; organic acid transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	55117
	103098
	ENSG00000072041
	ENSMUSG00000019894
	Q9H2J7
	Q8BG16
	NM_001146335; NM_018057; NM_182767
	NM_001252330; NM_175328; NM_001358821
	NP_001139807; NP_060527; NP_877499
	NP_001239259; NP_780537; NP_001345750
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium-dependent neutral amino acid transporter B(0)AT2 is a protein that in humans is encoded by the SLC6A15 gene.^[5]

Function

SLC6A15 shows structural characteristics of an Na⁺ and Cl⁻-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.^[6]

Clinical relevance

Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072041 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019894 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 6 (neutral amino acid transporter)".
^ Farmer MK, Robbins MJ, Medhurst AD, Campbell DA, Ellington K, Duckworth M, Brown AM, Middlemiss DN, Price GW, Pangalos MN (Dec 2000). "Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family". Genomics. 70 (2): 241–52. doi:10.1006/geno.2000.6387. PMID 11112352.
^ Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB (Apr 2011). "The neuronal transporter gene SLC6A15 confers risk to major depression". Neuron. 70 (2): 252–65. doi:10.1016/j.neuron.2011.04.005. PMC 3112053. PMID 21521612.

Bröer A, Tietze N, Kowalczuk S, Chubb S, Munzinger M, Bak LK, Bröer S (Jan 2006). "The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2)". The Biochemical Journal. 393 (Pt 1): 421–30. doi:10.1042/BJ20051273. PMC 1383701. PMID 16185194.
Zaia KA, Reimer RJ (Mar 2009). "Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport". The Journal of Biological Chemistry. 284 (13): 8439–48. doi:10.1074/jbc.M806407200. PMC 2659202. PMID 19147495.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Bröer S (Jan 2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiological Reviews. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
Takanaga H, Mackenzie B, Peng JB, Hediger MA (Nov 2005). "Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain". Biochemical and Biophysical Research Communications. 337 (3): 892–900. doi:10.1016/j.bbrc.2005.09.128. PMID 16226721.
Masson J, Sagné C, Hamon M, El Mestikawy S (Sep 1999). "Neurotransmitter transporters in the central nervous system". Pharmacological Reviews. 51 (3): 439–64. PMID 10471414.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072041 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019894 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: solute carrier family 6 (neutral amino acid transporter)".

[pmid11112352-6] Farmer MK, Robbins MJ, Medhurst AD, Campbell DA, Ellington K, Duckworth M, Brown AM, Middlemiss DN, Price GW, Pangalos MN (Dec 2000). "Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family". Genomics. 70 (2): 241–52. doi:10.1006/geno.2000.6387. PMID 11112352.

[pmid21521612-7] Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB (Apr 2011). "The neuronal transporter gene SLC6A15 confers risk to major depression". Neuron. 70 (2): 252–65. doi:10.1016/j.neuron.2011.04.005. PMC 3112053. PMID 21521612.

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Function

Clinical relevance

References

Further reading