Draft:Low-density lipoprotein receptor-related protein 6
Submission declined on 30 August 2024 by Ktkvtsh (talk).
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| Submission declined on 29 August 2024 by KylieTastic (talk). This draft's references do not show that the subject qualifies for a Wikipedia article. In summary, the draft needs multiple published sources that are: Declined by KylieTastic 2 months ago.
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Low-density lipoprotein receptor-related protein 6 (LRP6), is a protein that in humans is encoded by the LRP6 gene. LRP6 is a member of the low-density lipoprotein (LDLR) superfamily of cell-surface receptors family. It is a single-span transmembrane protein essential for the activation of Wnt/β-catenin signaling pathway.[1][2] LRP6 consists of four YWTD β-propeller domains, each of which is followed by an EGF-like domain, and this is followed by three LDLR type A repeats, a transmembrane helix, and a short intracellular domain.[3]
Genetic Mutations
[edit]A LRP6 mutant lacking the intracellular domain is defective in Wnt signaling[4] while LRP6 mutant lacking the extracellular domain (but anchored on the membrane) are constitutively active.[5]
Common genetic variants of LRP6 have been associated with the risks for hyperlipidemia,[6] atherosclerosis,[7] coronary disease,[8] and late-onset Alzheimer's disease[9] in the general population.
References
[edit]- ^ Tamai K, Zeng X, Liu C, Zhang X, Harada Y, Chang Z, He X (January 2004). "A Mechanism for Wnt Coreceptor Activation". Molecular Cell. 13 (1): 149–156. doi:10.1016/S1097-2765(03)00484-2. PMID 14731402.
- ^ MacDonald BT, He X (1 December 2012). "Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling". Cold Spring Harbor Perspectives in Biology. 4 (12): a007880. doi:10.1101/cshperspect.a007880. PMC 3504444. PMID 23209147.
- ^ Cheng Z, Biechele T, Wei Z, Morrone S, Moon RT, Wang L, Xu W (November 2011). "Crystal structures of the extracellular domain of LRP6 and its complex with DKK1". Nature Structural & Molecular Biology. 18 (11): 1204–1210. doi:10.1038/nsmb.2139. PMC 3249237. PMID 21984209.
- ^ Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X (September 2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. 407 (6803): 530–535. Bibcode:2000Natur.407..530T. doi:10.1038/35035117. PMID 11029007.
- ^ Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C (17 May 2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature. 411 (6835): 321–325. Bibcode:2001Natur.411..321M. doi:10.1038/35077108. PMID 11357136.
- ^ Tomaszewski M, Charchar FJ, Barnes T, Gawron-Kiszka M, Sedkowska A, Podolecka E, Kowalczyk J, Rathbone W, Kalarus Z, Grzeszczak W, Goodall AH, Samani NJ, Zukowska-Szczechowska E (September 2009). "A Common Variant in Low-Density Lipoprotein Receptor–Related Protein 6 Gene (LRP6) Is Associated With LDL-Cholesterol". Arteriosclerosis, Thrombosis, and Vascular Biology. 29 (9): 1316–1321. doi:10.1161/ATVBAHA.109.185355. PMC 2814817. PMID 19667113.
- ^ Sarzani R, Salvi F, Bordicchia M, Guerra F, Battistoni I, Pagliariccio G, Carbonari L, Dessì-Fulgheri P, Rappelli A (February 2011). "Carotid artery atherosclerosis in hypertensive patients with a functional LDL receptor-related protein 6 gene variant". Nutrition, Metabolism and Cardiovascular Diseases. 21 (2): 150–156. doi:10.1016/j.numecd.2009.08.004. PMID 19833493.
- ^ Mani A, Radhakrishnan J, Wang H, Mani A, Mani MA, Nelson-Williams C, Carew KS, Mane S, Najmabadi H, Wu D, Lifton RP (2 March 2007). "LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors". Science. 315 (5816): 1278–1282. Bibcode:2007Sci...315.1278M. doi:10.1126/science.1136370. PMC 2945222. PMID 17332414.
- ^ De Ferrari GV, Papassotiropoulos A, Biechele T, Wavrant De-Vrieze F, Avila ME, Major MB, Myers A, Sáez K, Henríquez JP, Zhao A, Wollmer MA, Nitsch RM, Hock C, Morris CM, Hardy J, Moon RT (29 May 2007). "Common genetic variation within the Low-Density Lipoprotein Receptor-Related Protein 6 and late-onset Alzheimer's disease". Proceedings of the National Academy of Sciences. 104 (22): 9434–9439. Bibcode:2007PNAS..104.9434D. doi:10.1073/pnas.0603523104. PMC 1890512. PMID 17517621.
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