Draft:Leucine rich repeat containing 27

Review waiting, please be patient.

This may take 3 months or more, since drafts are reviewed in no specific order. There are 1,546 pending submissions waiting for review.

If the submission is accepted, then this page will be moved into the article space.
If the submission is declined, then the reason will be posted here.
In the meantime, you can continue to improve this submission by editing normally.

Where to get help

If you need help editing or submitting your draft, please ask us a question at the AfC Help Desk or get live help from experienced editors. These venues are only for help with editing and the submission process, not to get reviews.
If you need feedback on your draft, or if the review is taking a lot of time, you can try asking for help on the talk page of a relevant WikiProject. Some WikiProjects are more active than others so a speedy reply is not guaranteed.

How to improve a draft

Wikipedia:Contributing to Wikipedia – a basic overview on how to edit Wikipedia.
Help:Wikitext – how to use the markup
Help:Referencing for beginners – how to include references
Wikipedia:Article development – how to develop your article
Wikipedia:Writing better articles – how to improve your article
Wikipedia:Verifiability – make sure your article includes reliable third-party sources

You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article.

Improving your odds of a speedy review

To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags.

Add tags to your draft

Editor resources

Find sources: Google (books · news · scholar · free images · WP refs) · FENS · JSTOR · TWL
Easy tools: Citation bot (help) | Advanced: Fix bare URLs

Reviewer tools

Instructions · What links here · Leucine rich repeat containing 27 (talk: + · bio) · (log) · Copyvios report · reFill · Citation Bot · (Search: Google, Bing, Wikipedia) · Submitted 44 days ago by Dhrmot (talk: D · +) · Last edited 17 days ago by Ktkvtsh

Comment: I'd say add some context for the general reader at the beginning before leading to the advanced information of the subject. Ktkvtsh (talk) 00:22, 26 August 2024 (UTC)

Comment: This article's references are online databases and two primary studies. It doesn't seem to me to pass WP:GNG, but it also doesn't seem that different to other articles about genes. I would recommend adding some secondary sources, and I'll watch to see other reviewers' views. Mgp28 (talk) 19:18, 8 August 2024 (UTC)

Leucine rich repeat containing 27 (LRRC27) isoform a is a protein which in humans is encoded by the LRRC27 gene.

Gene

Homo sapiens gene Leucine Rich Repeat containing 27 (LRRC27) is a protein coding gene that is located on chromosome 10 at 10q26.3..^[1]. The gene is on the plus (+) strand, and is 8251 base pairs long. The gene has 9 exons ^[2].

Transcript

LRRC27 has 45 transcript variants. Transcript variant 2 encodes isoform a in humans. The mRNA sequence for this variant is 8251 base pairs in length ^[3], and all 9 exons are present.

The LRRC27 transcript has low and variable expression in many tissues, but with notable amounts of the transcript present in the brain, fetal brain, and testis^[4] ^[5]

Protein

LRRC27 Isoform a in humans is 530 amino acids long with a predicted molecular weight of ~60 kDa and predicted isoelectric point around 9 ^[6]. It is relatively poor in tyrosine compared to other proteins ^[7]. LRRC27 is also largely localized in the nucleus of a cell ^[8].

Domains and Motifs

The protein has 5 leucine rich regions and 2 disordered regions^[9]

Structure

LRRC27 structure is largely helical, with strands present in the leucine rich regions of the protein ^[10]

Post-Translational Modifications

LRRC27 has several phosphorylation, o-linked glycosylation, and sumoylation sites that may change its structure post-translationally ^[11] ^[12]

Evolution

Paralogs

Paralogs for LRRC27 include LRRC7 (Leucine Rich Region Containing 7) and LRCH1 (Leucine Rich Repeats and Calponin Homology Domain Containing 1) ^[13].

Presence of the LRRC27 gene in classes Mammalia, Reptilia, Aves, Amphibian, and Fish are shown. Median date of Divergence from Homo sapiens, sequence identity, and sequence similarly to the human protein are included.

Orthologs

LRRC27 is widely conserved in mammals, and moderately conserved in certain reptiles, amphibians, fish and birds. There are no orthologs of this LRRC27 gene in invertebrates^[14]

Phylogeny/History

LRRC27 and LRCH1 are neither evolving as quickly as Fibrinogen Alpha nor as slowly as Cytochrome C. LRCH1 appears to also be changing at a slower rate compared to LRRC27.

Clinical Significance

Enriched LRRC27 expression is present in preeclampsia (PE) ^[15]. LRRC27 is overexpressed in platelets unique to PE, compared to a healthy pregnancy.

A single nucleotide polymorphism in LRRC27 is also significantly associated with the pathogenesis of primary open-angle glaucoma (POAG) ^[16]. Increased expression of LRRC27 with SNP rs116121322 was shown to be associated with POAG.

References

^ NCBI (National Center for Biotechnology Information) Nucleotide. Homo sapiens leucine rich repeat containing 27 (LRRC27). https://www.ncbi.nlm.nih.gov/nuccore/https://www.ncbi.nlm.nih.gov/nuccore/NM_001143757.2 .
^ NCBI (National Center for Biotechnology Information) Gene. Homo sapiens leucine rich repeat containing 27 (LRRC27). https://www.ncbi.nlm.nih.gov/gene/80313
^ NCBI (National Center for Biotechnology Information) Nucleotide. Homo sapiens leucine rich repeat containing 27 (LRRC27). https://www.ncbi.nlm.nih.gov/nuccore/https://www.ncbi.nlm.nih.gov/nuccore/NM_001143757.2
^ National Center for Biotechnology Information. GEO Profile results for LRRC27 AND GDS3113. https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS3113:170833
^ Szabo, L., Morey, R., Palpant, N.J. et al. Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol 16, 126 (2015). https://doi.org/10.1186/s13059-015-0690-5
^ Expasy. Compute pI/Mw. (https://web.expasy.org/cgi-bin/compute_pi/pi_tool.cgi )
^ EMBL-EBI SAPS. Sequence Statistics. (https://www.ebi.ac.uk/jdispatcher/seqstats/saps/summary?jobId=saps-I20240722-031647-0802-84915747-p1m&js=pass )
^ PSORT II Results for LRRC27 protein.[1]
^ National Center for Biotechnology Information (NCBI) Nucleotide results for LRRC27. https://www.ncbi.nlm.nih.gov/nuccore/NM_001143757.2
^ Predict Protein. Secondary Structure results for LRRC27. (https://predictprotein.org/visual_results?req_id=$2y$10$Gx3aBD1BHu5Z5vq.cdU7/uOrEV216aOp5Otixb3XTdz4ugk/w6qZ2#JobRunDialogue )
^ DTU Health Tech. Bioinformatic Services. (https://services.healthtech.dtu.dk/ )
^ The Cuckoo Group. GPS SUMO. (https://sumo.biocuckoo.cn/showResult.php )
^ GeneCards. The Human Gene Database. LRRC27 Paralogs. https://www.genecards.org/cgi-bin/carddisp.pl?gene=LRRC27#paralogs
^ National Center for Biotechnology Information (NCBI) Ortholog results for LRRC27. https://www.ncbi.nlm.nih.gov/gene/80313/ortholog/?scope=7742
^ de Almeida, L. G. N., Young, D., Chow, L., Nicholas, J., Lee, A., Poon, M. C., Dufour, A., & Agbani, E. O. (2022). Proteomics and Metabolomics Profiling of Platelets and Plasma Mediators of Thrombo-Inflammation in Gestational Hypertension and Preeclampsia. Cells, 11(8), 1256. https://doi.org/10.3390/cells11081256
^ Kim, Y. W., Kim, Y. J., Cheong, H. S., Shiga, Y., Hashimoto, K., Song, Y. J., Kim, S. H., Choi, H. J., Nishiguchi, K. M., Kawai, Y., Nagasaki, M., Nakazawa, T., Park, K. H., Kim, D. M., & Jeoung, J. W. (2020). Exploring the Novel Susceptibility Gene Variants for Primary Open-Angle Glaucoma in East Asian Cohorts: The GLAU-GENDISK Study. Scientific reports, 10(1), 221. https://doi.org/10.1038/s41598-019-57066-7

[1] NCBI (National Center for Biotechnology Information) Nucleotide. Homo sapiens leucine rich repeat containing 27 (LRRC27). https://www.ncbi.nlm.nih.gov/nuccore/https://www.ncbi.nlm.nih.gov/nuccore/NM_001143757.2 .

[2] NCBI (National Center for Biotechnology Information) Gene. Homo sapiens leucine rich repeat containing 27 (LRRC27). https://www.ncbi.nlm.nih.gov/gene/80313

[3] NCBI (National Center for Biotechnology Information) Nucleotide. Homo sapiens leucine rich repeat containing 27 (LRRC27). https://www.ncbi.nlm.nih.gov/nuccore/https://www.ncbi.nlm.nih.gov/nuccore/NM_001143757.2

[4] National Center for Biotechnology Information. GEO Profile results for LRRC27 AND GDS3113. https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS3113:170833

[5] Szabo, L., Morey, R., Palpant, N.J. et al. Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol 16, 126 (2015). https://doi.org/10.1186/s13059-015-0690-5

[6] Expasy. Compute pI/Mw. (https://web.expasy.org/cgi-bin/compute_pi/pi_tool.cgi )

[7] EMBL-EBI SAPS. Sequence Statistics. (https://www.ebi.ac.uk/jdispatcher/seqstats/saps/summary?jobId=saps-I20240722-031647-0802-84915747-p1m&js=pass )

[8] PSORT II Results for LRRC27 protein.[1]

[9] National Center for Biotechnology Information (NCBI) Nucleotide results for LRRC27. https://www.ncbi.nlm.nih.gov/nuccore/NM_001143757.2

[10] Predict Protein. Secondary Structure results for LRRC27. (https://predictprotein.org/visual_results?req_id=$2y$10$Gx3aBD1BHu5Z5vq.cdU7/uOrEV216aOp5Otixb3XTdz4ugk/w6qZ2#JobRunDialogue )

[11] DTU Health Tech. Bioinformatic Services. (https://services.healthtech.dtu.dk/ )

[12] The Cuckoo Group. GPS SUMO. (https://sumo.biocuckoo.cn/showResult.php )

[13] GeneCards. The Human Gene Database. LRRC27 Paralogs. https://www.genecards.org/cgi-bin/carddisp.pl?gene=LRRC27#paralogs

[14] National Center for Biotechnology Information (NCBI) Ortholog results for LRRC27. https://www.ncbi.nlm.nih.gov/gene/80313/ortholog/?scope=7742

[15] Almeida, L. G. N., Young, D., Chow, L., Nicholas, J., Lee, A., Poon, M. C., Dufour, A., & Agbani, E. O. (2022). Proteomics and Metabolomics Profiling of Platelets and Plasma Mediators of Thrombo-Inflammation in Gestational Hypertension and Preeclampsia. Cells, 11(8), 1256. https://doi.org/10.3390/cells11081256

[16] Kim, Y. W., Kim, Y. J., Cheong, H. S., Shiga, Y., Hashimoto, K., Song, Y. J., Kim, S. H., Choi, H. J., Nishiguchi, K. M., Kawai, Y., Nagasaki, M., Nakazawa, T., Park, K. H., Kim, D. M., & Jeoung, J. W. (2020). Exploring the Novel Susceptibility Gene Variants for Primary Open-Angle Glaucoma in East Asian Cohorts: The GLAU-GENDISK Study. Scientific reports, 10(1), 221. https://doi.org/10.1038/s41598-019-57066-7

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]