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Enrique de-Madaria

Enrique de-Madaria (born October 20, 1975, in Alicante, Spain), is a gastroenterologist and researcher specializing in pancreatic and biliary diseases.[1] His primary research focus is acute pancreatitis, particularly early-phase fluid therapy. He was the first Spaniard to receive the United European Gastroenterology Research Prize.[2] He is also the founder of the "Race of the Cities Against Pancreatic Cancer," an international sporting event that has raised over a million euros for pancreatic cancer research.[3]

Biography

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Enrique de-Madaria (Enrique de Madaria Pascual) was born in Alicante, Spain, in 1975. He studied medicine at the Miguel Hernández University of Elche and completed his residency in gastroenterology at the Hospital General Universitario de Alicante (currently known as Hospital General Universitario Dr. Balmis). He is in charge of the Biliopancreatic Unit at the Hospital General Universitario Dr. Balmis and is an associate professor at Miguel Hernandez University.

Research Contributions

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Since the late 1990s, aggressive intravenous fluid therapy was recommended for patients with acute pancreatitis, with the belief that resultant hemodilution would ensure adequate blood flow to the pancreas, preventing glandular necrosis and improving prognosis.[4] In 2011, Enrique de-Madaria published a prospective observational study indicating that patients receiving aggressive fluid therapy had a worse disease course.[5] In 2018, he conducted a single-center randomized clinical trial demonstrating that lactated Ringer's solution had anti-inflammatory properties in acute pancreatitis.[6] In 2022, he published the results of the WATERFALL randomized controlled trial in the New England Journal of Medicine.[7] This study compared aggressive versus moderate fluid therapy in 249 patients across 18 centers in four countries, showing that aggressive fluid therapy was unsafe and associated with a threefold increase in cardiopulmonary overload events. The findings influenced the 2024 American College of Gastroenterology guidelines to recommend moderate fluid therapy for acute pancreatitis based on this research.[8] Additionally, Enrique de-Madaria and his collaborators developed the PAN-PROMISE, a Patient Reported Outcome Measurement tool that assesses the main symptoms of acute pancreatitis. This scale was validated in an international study and is a useful tool for exploring the subjective experiences of patients with acute pancreatitis.[9]

Roles in Scientific Societies

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Enrique de-Madaria founded and served as the first president of the Spanish Pancreatology Association (AESPANC) from 2013 to 2016. He was also president of the Spanish Association of Gastroenterology from 2020 to 2023.[10]

Race of the Cities Against Pancreatic Cancer

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In January 2015, Enrique de-Madaria organized a charity run between the towns of Mutxamel and Sant Joan in Alicante, on behalf of the Spanish Association of Pancreatology (AESPANC), to raise awareness about the high mortality rate of pancreatic cancer and to fund research.[11] That same year, additional events took place in Alicante and Las Rozas, Madrid, in collaboration with the patient association ACANPAN. Since 2015, the event has expanded to 14 cities in Spain, attracting over 60,000 participants and raising more than one million euros for pancreatic cancer research. [3]

Awards

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Miguel Pérez Mateo Research Award in Gastroenterology (2016)[12] United European Gastroenterology (UEG) Rising Star Award (2017)[13] [14] TopDoctors Top 50 Best Doctors in Spain (2023)[15] United European Gastroenterology (UEG) Research Prize (2024)[16]

References

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  1. ^ "ORCID".
  2. ^ "UEG Research Prize".
  3. ^ a b "Carrera de Las Ciudades Contra el Cáncer de Páncreas website".
  4. ^ Gardner, T. B.; Vege, S. S.; Pearson, R. K.; Chari, S. T. (2008). "T.B.Gardner et al. Fluid resuscitation in acute pancreatitis. Clinical Gastroenterology and Hepatology 2008. Volume 6, Issue 10, P1070-1076". Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association. 6 (10): 1070–1076. doi:10.1016/j.cgh.2008.05.005. PMID 18619920.
  5. ^ De-Madaria, Enrique; Soler-Sala, Gema; Sánchez-Payá, José; Lopez-Font, Inmaculada; Martínez, Juan; Gómez-Escolar, Laura; Sempere, Laura; Sánchez-Fortún, Cristina; Pérez-Mateo, Miguel (October 2011). "E. de-Madaria et al. Influence of Fluid Therapy on the Prognosis of Acute Pancreatitis: A Prospective Cohort Study. American Journal of Gastroenterology 2011, Volume 106. Issue 10. P1843-1850". Official Journal of the American College of Gastroenterology | Acg. 106 (10): 1843–1850. doi:10.1038/ajg.2011.236. PMID 21876561.
  6. ^ De-Madaria, Enrique; Herrera-Marante, Iván; González-Camacho, Verónica; Bonjoch, Laia; Quesada-Vázquez, Noé; Almenta-Saavedra, Isabel; Miralles-Maciá, Cayetano; Acevedo-Piedra, Nelly G.; Roger-Ibáñez, Manuela; Sánchez-Marin, Claudia; Osuna-Ligero, Rosa; Gracia, Ángel; Llorens, Pere; Zapater, Pedro; Singh, Vikesh K.; Moreu-Martín, Rocío; Closa, Daniel (February 2018). "E. de-Madaria et al. Fluid resuscitation with lactated Ringer's solution vs normal saline in acute pancreatitis: A triple-blind, randomized, controlled trial. United European Gastroenterology Journal 2017, Volume 6. Issue 1. P63-72". United European Gastroenterology Journal. 6 (1): 63–72. doi:10.1177/2050640617707864. PMC 5802674. PMID 29435315.
  7. ^ De-Madaria, Enrique; Buxbaum, James L.; Maisonneuve, Patrick; Zapater, Pedro; Guilabert, Lucía; Vaillo-Rocamora, Alicia; Rodríguez-Gandía, Miguel Á.; Donate-Ortega, Jesús; Lozada-Hernández, Edgard E.; Collazo Moreno, Alan J. R.; Lira-Aguilar, Alba; Llovet, Laura P.; Mehta, Rajiv; Tandel, Raj; Navarro, Pablo; Sánchez-Pardo, Ana M.; Sánchez-Marin, Claudia; Cobreros, Marina; Fernández-Cabrera, Idaira; Casals-Seoane, Fernando; Casas Deza, Diego; Lauret-Braña, Eugenia; Martí-Marqués, Eva; Camacho-Montaño, Laura M.; Ubieto, Verónica; Ganuza, Mikel; Bolado, Federico (15 September 2022). "E. de-Madaria et al. Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis. The New England Journal of Medicine 2022, Volume 387. Issue 11. P989-1000". New England Journal of Medicine. 387 (11): 989–1000. doi:10.1056/NEJMoa2202884. PMID 36103415. {{cite journal}}: Missing |author4= (help)
  8. ^ Tenner, Scott; Vege, Santhi Swaroop; Sheth, Sunil G.; Sauer, Bryan; Yang, Allison; Conwell, Darwin L.; Yadlapati, Rena H.; Gardner, Timothy B. (March 2024). "S. Tenner et al. American College of Gastroenterology Guidelines: Management of Acute Pancreatitis. American Journal of Gastroenterology, 2024. Volume 119. Issue 3. P419-437". Official Journal of the American College of Gastroenterology | Acg. 119 (3): 419–437. doi:10.14309/ajg.0000000000002645. PMID 38857482.
  9. ^ De-Madaria, E.; Sánchez-Marin, C.; Carrillo, I.; Vege, S. S.; Chooklin, S.; Bilyak, A.; Mejuto, R.; Mauriz, V.; Hegyi, P.; Márta, K.; Kamal, A.; Lauret-Braña, E.; Barbu, S. T.; Nunes, V.; Ruiz-Rebollo, M. L.; García-Rayado, G.; Lozada-Hernandez, E. E.; Pereira, J.; Negoi, I.; Espina, S.; Hollenbach, M.; Litvin, A.; Bolado-Concejo, F.; Vargas, R. D.; Pascual-Moreno, I.; Singh, V. K.; Mira, J. J. (2021). "E. de-Madaria et al. Design and validation of a patient-reported outcome measure scale in acute pancreatitis: the PAN-PROMISE study. Gut, 2021. Volume 70. Issue 1. P 139-147". Gut. 70 (1): 139–147. doi:10.1136/gutjnl-2020-320729. PMID 32245906.
  10. ^ "Spanish Association of Gastroenterology (AEG)".
  11. ^ "D. Moltó. Carrera de fondo para lograr más investigación sobre cáncer de páncreas. El Mundo, 2019". 4 November 2019.
  12. ^ "Vithas hospitals. Enrique de Madaria, Premio Miguel Pérez-Mateo a la investigación sobre el páncreas. 2016". 30 May 2016.
  13. ^ "P. Alberola. Un médico del General de Alicante, entre los mejores jóvenes investigadores en aparato digestivo. Diario Información, 2017". 23 January 2017.
  14. ^ "UEG website, Young GI Blog. What you always wanted to know from UEG Rising Stars. 2019".
  15. ^ "TopDoctors Spain".
  16. ^ "UEG website. Research Prize".