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dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)

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DTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
Identifiers
EC no.1.1.1.339
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DTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) (EC 1.1.1.339, tll (gene name)) is an enzyme with systematic name dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

dTDP-6-deoxy-beta-L-talose + NAD+ dTDP-4-dehydro-6-deoxy-beta-L-mannose + NADH + H+

The enzyme from bacterium Aggregatibacter actinomycetemcomitans participates in the biosynthesis of the serotype c-specific polysaccharide antigen.

References

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  1. ^ Nakano Y, Suzuki N, Yoshida Y, Nezu T, Yamashita Y, Koga T (March 2000). "Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans". The Journal of Biological Chemistry. 275 (10): 6806–12. doi:10.1074/jbc.275.10.6806. PMID 10702238.
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