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1-Deoxypentalenic acid 11beta-hydroxylase

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1-deoxypentalenic acid 11beta-hydroxylase
Identifiers
EC no.1.14.11.35
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
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NCBIproteins

1-deoxypentalenic acid 11beta-hydroxylase (EC 1.14.11.35, PTLH (gene), SAV2991 (gene), PNTH (gene)) is an enzyme with systematic name 1-deoxypentalenic acid,2-oxoglutarate:oxygen oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

1-deoxypentalenate + 2-oxoglutarate + O2 1-deoxy-11beta-hydroxypentalenate + succinate + CO2

1-Deoxypentalenic acid 11beta-hydroxylase contains Fe(II) and ascorbate.

References

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  1. ^ You Z, Omura S, Ikeda H, Cane DE (May 2006). "Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlH, a non-heme iron dioxygenase of Streptomyces avermitilis". Journal of the American Chemical Society. 128 (20): 6566–7. doi:10.1021/ja061469i. PMC 2533727. PMID 16704250.
  2. ^ You Z, Omura S, Ikeda H, Cane DE, Jogl G (December 2007). "Crystal structure of the non-heme iron dioxygenase PtlH in pentalenolactone biosynthesis". The Journal of Biological Chemistry. 282 (50): 36552–60. doi:10.1074/jbc.M706358200. PMC 3010413. PMID 17942405.
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