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Zinc finger protein 426

From Wikipedia, the free encyclopedia
ZNF426
Identifiers
AliasesZNF426, K-RBP, zinc finger protein 426
External IDsMGI: 1920248; HomoloGene: 23435; GeneCards: ZNF426; OMA:ZNF426 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300883
NM_024106
NM_001318055
NM_001318056

NM_001110309
NM_146221
NM_001310742

RefSeq (protein)

NP_001287812
NP_001304984
NP_001304985
NP_077011

NP_001103779
NP_001297671
NP_666333

Location (UCSC)Chr 19: 9.52 – 9.54 MbChr 9: 20.38 – 20.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 426 is a protein that in humans is encoded by the ZNF426 gene. [5]

Function

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Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130818Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059475Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Zinc finger protein 426". Retrieved 2016-01-28.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.