ZNF746

ZNF746
Identifiers
Aliases	ZNF746, P.A.R.I.S, PARIS, zinc finger protein 746
External IDs	OMIM: 613914; MGI: 1916478; HomoloGene: 19783; GeneCards: ZNF746; OMA:ZNF746 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	149,497,817 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	48,063,527 bp
RNA expression pattern
	Top expressed in
	blood; ; granulocyte; ; mucosa of ileum; ; spleen; ; monocyte; ; bone marrow cells; ; left testis; ; stromal cell of endometrium; ; right testis; ; sural nerve;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; granulocyte; ; genital tubercle; ; blood; ; spermatocyte; ; condyle; ; Paneth cell; ; fossa;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; ubiquitin protein ligase binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; intracellular anatomical structure; nucleus;
Biological process	negative regulation of transcription, DNA-templated; positive regulation of neuron death; negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	155061
	69228
	ENSG00000181220
	ENSMUSG00000057691
	Q6NUN9
	Q3U133
	NM_001163474; NM_152557; NM_001363517; NM_001394198
	NM_001163475; NM_001347142; NM_001362062
	NP_001156946; NP_689770; NP_001350446
	NP_001156947; NP_001334071; NP_001348991
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 746 also known as Parkin-interacting substrate (PARIS) is a zinc finger protein that, in humans, is encoded by the ZNF746 gene and is involved in the neurodegeneration of Parkinson's disease.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181220 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057691 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, et al. (March 2011). "PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease". Cell. 144 (5): 689–702. doi:10.1016/j.cell.2011.02.010. PMC 3063894. PMID 21376232.
^ "Entrez Gene: ZNF746 zinc finger protein 746 [ Homo sapiens (human) ]".

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181220 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057691 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10718198-5] Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, et al. (March 2011). "PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease". Cell. 144 (5): 689–702. doi:10.1016/j.cell.2011.02.010. PMC 3063894. PMID 21376232.

[entrez-6] "Entrez Gene: ZNF746 zinc finger protein 746 [ Homo sapiens (human) ]".

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