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ZEB2-AS1

From Wikipedia, the free encyclopedia
ZEB2-AS1
Identifiers
AliasesZEB2-AS1, ZEB2-AS, ZEB2AS, ZEB2NAT, ZEB2 antisense RNA 1
External IDsGeneCards: ZEB2-AS1; OMA:ZEB2-AS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)Chr 2: 144.52 – 144.52 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

ZEB2-AS1 (ZEB2 antisense RNA 1) is a long non-coding RNA, which is overlapping and antisense to the ZEB2 gene.[3][4] It overlaps the 5′ splice site of an intron within the 5′UTR of the ZEB2 gene. This intron contains an internal ribosome entry site (IRES), which is necessary for ZEB2 expression. ZEB2-AS1 prevents the splicing of this intron, and therefore activates ZEB2 expression.[4]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000238057Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Nelles L, Van de Putte T, van Grunsven L, Huylebroeck D, Verschueren K (October 2003). "Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1". Genomics. 82 (4): 460–469. doi:10.1016/S0888-7543(03)00169-1. PMID 13679026.
  4. ^ a b Beltran M, Puig I, Peña C, et al. (March 2008). "A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition". Genes Dev. 22 (6): 756–769. doi:10.1101/gad.455708. PMC 2275429. PMID 18347095.

Further reading

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