YCT529

YCT529
Identifiers
	IUPAC name 4-[5-[2,2-dimethyl-4-(4-methylphenyl)chromen-6-yl]-1H-pyrrol-2-yl]benzoic acid;
CAS Number	2863670-66-8 ;
PubChem CID	162679554;
ChemSpider	128921383;
Chemical and physical data
Formula	C29H25NO3
Molar mass	435.523 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC=C(C=C1)C2=CC(OC3=C2C=C(C=C3)C4=CC=C(N4)C5=CC=C(C=C5)C(=O)O)(C)C;
	InChI InChI=1S/C29H25NO3/c1-18-4-6-19(7-5-18)24-17-29(2,3)33-27-15-12-22(16-23(24)27)26-14-13-25(30-26)20-8-10-21(11-9-20)28(31)32/h4-17,30H,1-3H3,(H,31,32); Key:QLXSCDXZOYRDAX-UHFFFAOYSA-N;

YCT529 is a drug which acts as a potent and selective antagonist of the Vitamin A receptor retinoic acid receptor alpha (RAR-α). In studies on mice it produced a 99% reduction in sperm production, and it has proceeded to early stage human clinical trials as a potential male contraceptive.^[1]

The Vitamin A signalling system plays a number of important roles in bodily systems, such as the Immune system “It seems to me inherently unlikely that a compound with such activity would be free of side effects,” says Richard Sharpe, of the University of Edinburgh.^[2]

References

^ "A non-hormonal pill could soon expand men's birth control options". ACS News. 23 March 2022.
^ Wilkins A (23 March 2022). "Male contraceptive pill is safe and effective in tests in mice". New Scientist.

[1] "A non-hormonal pill could soon expand men's birth control options". ACS News. 23 March 2022.

[2] Wilkins A (23 March 2022). "Male contraceptive pill is safe and effective in tests in mice". New Scientist.

[1]

[2]

See also

References