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Wylie Burke

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Wylie Burke
Burke in 2013
Born
Utica, NY[1]
Alma materUniversity of Washington
Scientific career
FieldsGenetics
InstitutionsUniversity of Washington, Northwest-Alaska Pharmacogenomics Research Network
External media
Audio
audio icon “Wylie Burke on genomics, precision medicine, and healthcare policy”, podcast, Genome Alberta, July 10, 2015.
Video
video icon Risks and Benefits of Genetic Testing, Wylie Burke, University of Washington, November 22, 2013

Wylie Burke is a Professor Emerita and former Chair of the Department of Bioethics and Humanities at the University of Washington and a founding co-director of the Northwest-Alaska Pharmacogenomics Research Network, which partners with underserved populations in the Pacific Northwest and Alaska.

Burke's work focuses on ethical, legal, and social implications of genetic information for research and health care. She is an elected member of the National Academy of Medicine and the Association of American Physicians, and a past president of the American Society of Human Genetics.

Early life and education

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Burke attended Brooklyn College, graduating summa cum laude in 1970. She then studied at the University of Washington, receiving a PhD in Genetics in 1974 and completing her MD with a residency in Internal Medicine.[1][2] Next she spent several years as a primary care doctor at a community hospital.[3] Burke returned to the University of Washington as a Medical Genetics Fellow from 1981-1982.[4]

Career

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Burke joined the Department of Medicine at the University of Washington in 1983. She served as the associate director of the Internal Medicine Residency Program from 1988 to 1994 and as the founding director of the Women’s Health Care Center at the University of Washington from 1994-1999. In 2000, she became director of the Department of Medical History and Ethics. It was renamed the Department of Bioethics and Humanities in 2008. Burke stepped down as chair in 2014.[1][4]

Burke is now Professor Emerita of the University of Washington. She is also an adjunct professor of medicine and epidemiology and a member of the Fred Hutchinson Cancer Research Center. The Department of Bioethics & Humanities at the University of Washington has created an endowed scholarship for diversity in her name.[5]

Burke was a visiting scientist at the Centers for Disease Control and Prevention in 1998. She served on the NIH National Advisory Council for Human Genome Research from 1999-2003 and the Department of Health and Human Services Advisory Committee on Genetic Testing from 1999-2002.[6] Burke was the founding Principal Investigator of the University of Washington's Center for Genomics and Healthcare Equality from 2004–2017, one of the NIH Centers of Excellence in Ethical, Legal and Social Implications (ELSI) Research, which were funded by the National Human Genome Research Institute.[3][7][8][9] She served on the National Academies' Committee on the Return of Individual-Specific Results Generated in Research Laboratories, which released a report in 2018 recommending guidelines for researchers and institutions.[10][11]

Burke is a founding co-director with Ken Thummel of the Northwest-Alaska Pharmacogenomics Research Network.[12] The network was formed in 2009 as a research partnership between tribal organizations and universities[3] to study pharmacogenomics in rural and underserved populations in the Pacific Northwest and Alaska.[12][13][14][15] It received funding from the National Institutes of Health (NIH).[16] American Indian and Alaska Native (AI/AN) people are disproportionately likely to be designated as medically underserved, as a result of lower availability of primary care physicians and higher than average percentages for infant mortality, incomes below the poverty level, and people 65 years or older.[17] Current university partners include the University of Washington, the University of Alaska Fairbanks, the Oregon Health & Science University, and the University of Montana.[18]

Burke has been an international fellow at the National Health Service in Cambridge, United Kingdom.[19] Burke was director of the American Society of Human Genetics (ASHG) from 2002 to 2004 and a member of its Social Issues Committee from 2004 to 2006. In 2007 she served as ASHG President.[1][20]

Research

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Burke examines the ethical, legal, and social implications of human genetics. She is particularly concerned with the translation of novel genomic technologies from their development in the lab to their use in the health system and community.[21] She is regarded as a national leader in ethics and policy dealing with human genome research, addressing fundamental and difficult questions with respect for those involved.[7]

Among the issues of concern to Burke are clinical utility — what genetic information will be of help to a particular patient, how can this be determined, and are there potential harms to a patient? — and equity — are interventions which have clinical utility available to all who can benefit from it? Are diverse populations and individuals being taken into account?[3]

Awards

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Publications

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References

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  1. ^ a b c d Ratzel, Sarah; Cullinan, Sara B. (November 3, 2016). "Wylie Burke, M.D., Ph.D., President, American Society of Human Genetics, 2007". The American Journal of Human Genetics. 99 (5): 1001–1224. doi:10.1016/j.ajhg.2016.10.007.
  2. ^ "2020 Advancing Ethical Research Virtual Conference". 2020 Advancing Ethical Research Conference. Retrieved 7 February 2022.
  3. ^ a b c d Burke, Wylie (31 August 2021). "Utility and Diversity: Challenges for Genomic Medicine". Annual Review of Genomics and Human Genetics. 22 (1): 1–24. doi:10.1146/annurev-genom-120220-082640. ISSN 1527-8204. PMID 33792358. S2CID 232483454.
  4. ^ a b Institute of Medicine (20 June 2013). The Economics of Genomic Medicine: Workshop Summary. Washington, D.C.: National Academies Press. ISBN 978-0-309-26973-5. Retrieved 7 February 2022.
  5. ^ "2022 Wylie Burke Endowed Scholarship for Diversity!". UW Department of Bioethics & Humanities. Retrieved 7 February 2022.
  6. ^ a b "2016 Cowan Memorial Lectureships with Wylie Burke, MD, PhD". School of Medicine, University of Utah. March 11, 2016. Retrieved 7 February 2022.
  7. ^ a b c Foster, Krystal (12 July 2021). "ASHG Honors Wylie Burke, MD, PhD with the 2021 Victor A. McKusick Leadership Award". American Society of Human Genetics. Retrieved 7 February 2022.
  8. ^ "Wylie Burke, MD, PhD". UW Department of Bioethics & Humanities. Retrieved 7 February 2022.
  9. ^ Herndon, Megan (November 16, 2015). "UW Ph.D. candidates working to include indigenous voices in genomic research". The Daily of the University of Washington. Retrieved 7 February 2022.
  10. ^ "New Report Says Individual Research Results Should Be Shared With Participants More Often; Recommends Framework for Decision-Making". National Academies of Sciences, Engineering, and Medicine. July 10, 2018. Retrieved 8 February 2022.
  11. ^ Division, Health Medicine (2018). Returning Individual Research Results to Participants: Guidance for a New Research Paradigm. National Academies Press. ISBN 9780309475174. Retrieved 8 February 2022. {{cite book}}: |website= ignored (help)
  12. ^ a b "CANHR researchers team up to study drug/gene interaction" (PDF). News from the Center for Alaska Native Health Research. 8 (1). 2011. Retrieved 7 February 2022.
  13. ^ "Pharmacogenomics Research Network (PGRN)". School of Pharmacy. University of Washington. Retrieved 7 February 2022.
  14. ^ "Parent Project Number 5P01GM116691-05". NIH Reporter. Retrieved 7 February 2022.
  15. ^ Morales, Chelsea T.; Muzquiz, LeeAnna I.; Howlett, Kevin; Azure, Bernie; Bodnar, Brenda; Finley, Vernon; Incashola, Tony; Mathias, Cheryl; Laukes, Cindi; Beatty, Patrick; Burke, Wylie; Pershouse, Mark A.; Putnam, Elizabeth A.; Trinidad, Susan Brown; James, Rosalina; Woodahl, Erica L. (2016). "Partnership with the Confederated Salish and Kootenai Tribes: Establishing an Advisory Committee for Pharmacogenetic Research". Progress in Community Health Partnerships: Research, Education, and Action. 10 (2): 169–170. doi:10.1353/cpr.2016.0029. ISSN 1557-0541. PMC 5850964. PMID 27346761.
  16. ^ "Improving Care for Alaska Native People". University of Washington, School of Pharmacy. 13 September 2019. Retrieved 8 February 2022.
  17. ^ Woodahl, Erica L; Lesko, Lawrence J; Hopkins, Scarlett; Robinson, Renee F; Thummel, Kenneth E; Burke, Wylie (2014). "Pharmacogenetic research in partnership with American Indian and Alaska Native communities". Pharmacogenomics. 15 (9): 1235–1241. doi:10.2217/pgs.14.91. ISSN 1462-2416. PMC 4201360. PMID 25141898.
  18. ^ "Northwest-Alaska Pharmacogenetic Research Network". UW Research. Retrieved 8 February 2022.
  19. ^ National Research Council (2014). "Appendix C: Biographical Sketches of Steering Committee Members and Presenters". Issues in returning individual results from genome research using population-based banked specimens, with a focus on the National Health and Nutrition Examination Survey : workshop summary. Washington, D.C.: The National Academies Press. ISBN 978-0-309-30704-8. Retrieved 7 February 2022.
  20. ^ Burke, Wylie (May 2008). "ASHG Presidential Address: Who Is under the Umbrella—and Why Are We Here?" (PDF). The American Journal of Human Genetics. 82 (5): 1029–1031. doi:10.1016/j.ajhg.2008.04.010. PMC 2427266. PMID 20529637. Retrieved 7 February 2022.
  21. ^ a b "Wylie Burke Named UCSF Presidential Chair". UCSF School of Nursing. Retrieved 7 February 2022.
  22. ^ "National Academy of Medicine (formerly Institute of Medicine)". UW Research. Retrieved 7 February 2022.
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