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Group 82D

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This is the Wikipedia page for 410.602 Molecular Biology, Spring, 2013, group 82D. This group will be working on the article Missense mutation.

Use the talk page here to collaborate as a group, when learning to use and navigate Wikipedia, assessing articles, or for any other topic.

Use this page (not the talk page) for article assessments; rationale for selecting an article; etc.

Please create a new section here for each of those assignments.

Final Progress Report (Unit 14)

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Since the last progress report, the following changes have been made:

  • We figured out the wiki markup to improve the tables in the article. There were two tables that were updated in "Relationships with other mutations" section.
  • We were able to implement spelling and grammar fixes in addition to wording improvements as suggested by the reviewers.
  • We mentioned DNA in the lead paragraph as suggested by many reviewers and expanded a little bit more on the end to make it more proportional to the rest of the article.
    • Added another reference to the lead paragraph and fixed other references to be consistent with the other references in the article.
  • Thank you so much to all the reviewers and Klortho for all your help in reviewing this article and providing feedback.

Overall, this article was improved from being a small stub article at the beginning of the semester to being a much more complete article with many new sections covering most of the essential information and more. Furthermore, there were images and tables added, while the references were clean up and expanded upon. Bcheon1 (talk) 18:32, 10 May 2013 (UTC)[reply]

Unit 9 Progress Report

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  • We found an image illustrating an example of missense mutation on a site affiliated with the U.S. National Library of Medicine.
    • We uploaded it to Wikimedia Commons here after consulting Klortho.
    • We added the image to the article for missense mutation as an enlarged thumbnail.
  • We created a new section on and outlined the various causes of missense mutation including spontaneous mutations, DNA replication errors and exposure to mutagenic environmental factors.
  • We made a new section on and went into detail about suppressors and how they relate to missense mutation in addition to going into some of the various mechanisms.
  • We made a new section for diseases related to missense mutations and moved the sickle cell disease part down there.
    • We edited the subsection on sickle cell disease to be more substantial.
    • We talked about Parkinson’s Disease and how it relates to our topic.
    • We also talked about Congenital nephrotic syndrome of the Finnish type and how it relates to our topic.
    • We included a subsection on Sagliker syndrome.

Article selection rationale.

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Our group chose to work on the missense mutation article for several reasons.

  • First, we noticed that this article is currently of Stub quality even though it is of High Importance on the WikiProject Molecular and Cellular Biology. This means that this article has fairly high priority and really should be getting more attention.
  • Next, we saw that the current state of development for the article seems to be just right. This article has a fair bit of development so that our group doesn't have to spend an inordinate amount of time in creating the basic framework. But on the other hand, this article is underdeveloped to the extent that our group will have many viable venues to improve on.
  • Another reason we chose this article is that we were able to find many informative secondary sources regarding this topic and so we are quite confident that we have plenty of information to work with. Some articles we considered like RecA had most of the research done in the past few years and were lacking inclusion in secondary sources. Missense mutation on the other hand is fairly well known and this topic is rich with information as well as various parallels such as diseases causes by missense mutations.
  • Finally, our group chose this article because it is goes well with our coursework. This topic will be covered in a few weeks with Chapter 15 and we hope that the coursework will give us a solid foundation in understanding this concept as we look into secondary sources.

Initial article assessments from user Bcheon1 (Unit 5 Assignment)

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Missense mutation

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Link: Missense mutation

Assessment:

  • This article gives a very rough general overview, but any other information is sparse.
    • There are a few details but they seem to be relatively random that are slapped together.
  • Spacing is inconsistent and the only section present after the lead section is barely developed.
  • There are few references and those present are inconsistent in formatting.
  • There is no media present, though it is almost necessary to visualize the concepts presented here.
  • Everything seems to have been done haphazardly.
  • I would rate this as a Stub class article or perhaps a low level Start class article at best.
adding assessment from mhk5600.
* Noticed that this article is marked as `needs additional citation for verification` at the top of page.
* a detail about this mutation with a diagram/illustration at the introduction part to help audience to understand and learn.
* Coverage by article can be extended to a little further, such as adding more example cases by comparing among Eukaryote, Eukaryote and bacteria and others.
* Could add external links where another source of summary about this mutation could be found.
* curious to see, if this mutation could be used in a helpful way like a drug target. (example case in RecA)

Possible Improvements:

  • Fix references so that all the appropriate bibliographic information is given.
  • Add figures.
    • The example explaining sickle cell disease mutation could use a figure.
  • Create more sections.
    • A Clinical significance section would be useful.
  • Add links to other types of point mutations.
  • Add content in general and go into more detail for what is already mentioned.

Potential References:

  • Brubaker RR (2012). "Consequences of missense mutations in Yersinia pestis: efficient flow of metabolic carbon versus virulence". Advances in Yersinia Research. Adv. Exp. Med. Biol. Vol. 954. pp. 31–8. doi:10.1007/978-1-4614-3561-7_4. ISBN 978-1-4614-3560-0. PMID 22782743.
  • Rauch A, Wieczorek D, Graf E, et al. (November 2012). "Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study". Lancet. 380 (9854): 1674–82. doi:10.1016/S0140-6736(12)61480-9. PMID 23020937. S2CID 22096802.
  • Macdonald RL, Kang JQ (December 2012). "mRNA surveillance and endoplasmic reticulum quality control processes alter biogenesis of mutant GABAA receptor subunits associated with genetic epilepsies". Epilepsia. 53 (Suppl 9): 59–70. doi:10.1111/epi.12035. PMC 3762703. PMID 23216579.

RecA

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Link: RecA

Assessment:

  • Compared to the missense mutation article, the RecA article is in a lot better shape. There is a nice infobox with a lot of the core information.
    • There is a nice general overview but the other aspects are rough and are missing details.
  • References are sparse.
    • All but one of the references seem to be consistent.
  • There is a decent amount of information but most of the information seems to be squished together in the lead section.
    • Distinct logical organization of sections is lacking.
  • I would rate this somewhere between Stub class and Start class.
adding assessment from mhk5600.
  • Marked as 'high-important' by Wiki-Microbiology and Wiki-Molecular and Cellular Biology
  • Agreed that it is in a lot better shape.
  • Likewise in missense mutation article, Coverage by article can be extended to a little further, such as adding more example cases by comparing among Eukaryote, Eukaryote and bacteria and others. I am guessing that a summary of this kind of example case would be helpful for audience to understand and follow
  • Like to see a coverage in 'potential as a drug target'. Do we need to expand this part?

Possible Improvements:

  • Add some more content in general.
    • Add a section on clinical significance with associated diseases and mutations.
  • Fix the last reference so that it is consistent with the rest.
  • Create a logical organization with new sections including: gene, protein, distribution, and history.
    • Move appropriate information to relevant sections and add more details to make them substantial.
  • More media would be useful.

Potential References:

  • Liu W, Li L, Khan MA, Zhu F (2012). "Popular molecular markers in bacteria". Mol. Gen. Mikrobiol. Virusol. (3): 14–7. PMID 22984767.
  • Richert K, Brambilla E, Stackebrandt E (March 2007). "The phylogenetic significance of peptidoglycan types: Molecular analysis of the genera Microbacterium and Aureobacterium based upon sequence comparison of gyrB, rpoB, recA and ppk and 16SrRNA genes". Syst. Appl. Microbiol. 30 (2): 102–8. doi:10.1016/j.syapm.2006.04.001. PMID 16684595.
  • Holmes DE, Nevin KP, Lovley DR (September 2004). "Comparison of 16S rRNA, nifD, recA, gyrB, rpoB and fusA genes within the family Geobacteraceae fam. nov". Int. J. Syst. Evol. Microbiol. 54 (Pt 5): 1591–9. doi:10.1099/ijs.0.02958-0. PMID 15388715.

Initial article assessments from mhk5600

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Maintaining overall format in a group page.

Origin of replication[1]

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Assessment:

  • Surprisingly low activity, compare to a level of important, WikiProject Molecular and Cellular Biology rated this article as High-important. The last talk activity was at year 2008 and 2006.
  • Overall structure has been established, Prokaryotic, Eukaryotic and Viral.
  • Current references targets do all exist. They are stable and detail in a technical papers.
  • One of reference point is pointing a company's web site. That may not be suitable to meet a guideline.

Possible Improvements:

  • Figure and Illustration on topics are needed per different living organism.
  • Need to expand within Prokaryotic, Eukaryotic level, such as E.coli, phage, Mammal, etc.
  • Depth of contents could be a detail and deep as it is an important concept in Biology area.

Potential References:

Phylogenomics[2]

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Assessment:

  • It has been very little work done with no discussion of any kind.
  • WikiProject Molecular and Cellular Biology rated this article as High-important and Stub-Class.
  • An introduction part is very much dry with a list of terminology.
  • As it is a relatively new concept, article needs to focus on stable contents.

Possible Improvements:

  • Detail and broad range of introduction is needed, before article proceeds to a gene function.
  • By adding figure or a good animation from reference sources, reader may feel easy to understand.
  • Jonathan Eisen, who coined Phylogenomics, and other evolutionary biologist's activities are needed.
  • Need to check a reference, if they are still valid or stable contents.

Potential References:

Notes

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  1. ^ Wikipedia. "Origin of replication". Wikipedia.
  2. ^ Wikipedia. "Phylogenomics". Wikipedia.
  3. ^ Eisen, Jonathan. "Jonathan Eisen's Lab".
  4. ^ Murphy, William (2008). Phylogenomics. College Station, TX, USA: Library Genesis. ISBN 978-1-58829-764-8.
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