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Wallace P. Rowe

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Wallace Prescott Rowe (February 20, 1926, Baltimore – July 4, 1983, Baltimore) was an American virologist, known for his research on retroviruses and oncoviruses and as a co-discoverer (with Robert J. Huebner and three other researchers in 1953) of adenoviruses.[1][2][3][4][5][6]

Rowe graduated in 1945 with a B.S. from the College of William and Mary.[1] In 1945 he served in the U.S. Navy.[7] In 1948 he graduated with an M.D. from Johns Hopkins Medical School. From 1949 to 1952 he was a virologist at the Naval Medical Research Institute in Bethesda, Maryland,[1] where he worked in Erich Traub's laboratory.[8] From 1952 until his death in 1983 Rowe was a federal civil servant employed by the U.S. Public Health Service (USPHS) and the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH). In 1952 he started with the tile and pay grade of assistant surgeon. He was promoted in 1956 to full surgeon and in 1968 to chief of the laboratory for NIAID.[1] From 1960 to 1974 he taught part-time at Howard University.[7]

Rowe and his colleagues showed that retroviruses can cause leukemia in mice.[9][10][11][12][13] He was among the first "to recognize the role of the immune response in the pathogenesis of murine lymphocytic choriomeningitis."[1][14] He was a pioneer in research on adenoviruses[15][16] and their role in human diseases.[17][1]

The discoveries of adenoviruses by Rowe et al. (1953) and by Hilleman and Werner (1954) aroused great interest and excitement among clinicians and virologists alike in that no new acute viral respiratory disease of humans had been isolated since the identification of influenza virus 20 years earlier (Smith et al., 1933).[18]

Rowe married Marjorie Louise Power (1927–2006) on 29 May 1948 in Williamsburg, Virginia. They had a son and a daughter. After divorcing his first wife, Wallace Rowe married the virologist Paula Pitha (1937–2015).

Awards and honors

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References

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  1. ^ a b c d e f g h i j "Wallace P. Rowe". Member Directory, National Academy of Sciences.
  2. ^ Rowe, Wallace P.; Pugh, Wendell E.; Hartley, Janet W. (1970). "Plaque assay techniques for murine leukemia viruses". Virology. 42 (4): 1136–1139. doi:10.1016/0042-6822(70)90362-4. PMID 4099080. (over 1400 citations)
  3. ^ Rowe, W. P.; Huebner, R. J.; Gilmore, L. K.; Parrott, R. H.; Ward, T. G. (1953). "Isolation of a Cytopathogenic Agent from Human Adenoids Undergoing Spontaneous Degeneration in Tissue Culture". Experimental Biology and Medicine. 84 (3): 570–573. doi:10.3181/00379727-84-20714. PMID 13134217. S2CID 3097955. (over 1300 citations)
  4. ^ Hartley, J. W.; Wolford, N. K.; Old, L. J.; Rowe, W. P. (1977). "A new class of murine leukemia virus associated with development of spontaneous lymphomas". Proceedings of the National Academy of Sciences. 74 (2): 789–792. Bibcode:1977PNAS...74..789H. doi:10.1073/pnas.74.2.789. PMC 392380. PMID 191826. (over 800 citations)
  5. ^ Lowy, D. R.; Rowe, W. P.; Teich, N.; Hartley, J. W. (1971). "Murine Leukemia Virus: High-Frequency Activation in vitro by 5-Iododeoxyuridine and 5-Bromodeoxyuridine". Science. 174 (4005): 155–156. Bibcode:1971Sci...174..155L. doi:10.1126/science.174.4005.155. PMID 4330367. S2CID 45402929. (over 700 citations)
  6. ^ Staal, S. P.; Hartley, J. W.; Rowe, W. P. (1977). "Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma". Proceedings of the National Academy of Sciences. 74 (7): 3065–3067. Bibcode:1977PNAS...74.3065S. doi:10.1073/pnas.74.7.3065. PMC 431413. PMID 197531.
  7. ^ a b c d "Dr. Wallace P. Rowe, 57, Dies; A Leader in Cancer Research" (PDF). New York Times. July 9, 1983. p. 7, section 1.
  8. ^ Bhatt, Pravin, ed. (2 December 2012). "Chapter 2. Dedication (to Wallace Prescott Rowe) by Janet W. Hartley". Viral and Mycoplasmal Infections of Laboratory Rodents: Effects on Biomedical Research. Elsevier Science. pp. 7–13. ISBN 978-0-323-14218-2.
  9. ^ Rowe, W. P. (1961). "The Epidemiology of Mouse Polyoma Virus Infection". Bacteriological Reviews. 25 (1): 18–31. doi:10.1128/MMBR.25.1.18-31.1961. PMC 441071. PMID 13744141.
  10. ^ Rowe, Wallace P. (1982). "Genetic interactions between tumor viruses and host cells". Cancer. 49 (10): 1958–1962. doi:10.1002/1097-0142(19820515)49:10<1958::AID-CNCR2820491003>3.0.CO;2-#. PMID 7074521. S2CID 196604117.
  11. ^ Hopkins, N.; Rowe, W. P.; Hartley, J. W.; Holland, C. A. (January 1985). "At least four viral genes contribute to the leukemogenicity of murine retrovirus MCF 247 in AKR mice". Journal of Virology. 53 (1): 158–165. doi:10.1128/JVI.53.1.158-165.1985. PMC 254998. PMID 2981335.
  12. ^ Fredrickson, T. N.; Morse H. C., 3rd; Yetter, R. A.; Rowe, W. P.; Hartley, J. W.; Pattengale, P. K. (1985). "Multiparameter analyses of spontaneous nonthymic lymphomas occurring in NFS/N mice congenic for ecotropic murine leukemia viruses". The American Journal of Pathology. 121 (2): 349–360. PMC 1888063. PMID 2998195.{{cite journal}}: CS1 maint: numeric names: authors list (link)
  13. ^ Rowe, W. (1983). "Deformed whiskers in mice infected with certain exogenous murine leukemia viruses". Science. 221 (4610): 562–564. Bibcode:1983Sci...221..562R. doi:10.1126/science.6306769. PMID 6306769.
  14. ^ Pugh, W. E.; Wilsnack, R. E.; Smith, G. H.; Rowe, W. P.; Dalton, A. J. (December 1968). "Morphological and Cytochemical Studies on Lymphocytic Choriomeningitis Virus". Journal of Virology. 2 (12): 1465–1478. doi:10.1128/JVI.2.12.1465-1478.1968. PMC 375491. PMID 4986483.
  15. ^ Hoggan, M. D.; Blacklow, N. R.; Rowe, W. P. (1966). "Studies of small DNA viruses found in various adenovirus preparations: Physical, biological, and immunological characteristics". Proceedings of the National Academy of Sciences. 55 (6): 1467–1474. Bibcode:1966PNAS...55.1467H. doi:10.1073/pnas.55.6.1467. PMC 224346. PMID 5227666.
  16. ^ Huebner, R. J.; Rowe, W. P.; Lane, W. T. (1962). "Oncogenic Effects in Hamsters of Human Adenovirus Types 12 and 18". Proceedings of the National Academy of Sciences. 48 (12): 2051–2058. Bibcode:1962PNAS...48.2051H. doi:10.1073/pnas.48.12.2051. PMC 221121. PMID 13955470.
  17. ^ "Serologic Evidence for Human Infection with Adenovirus-Associated Viruses". JNCI: Journal of the National Cancer Institute. 1968. doi:10.1093/jnci/40.2.319.
  18. ^ Ginsberg, Harold S., ed. (8 March 2013). "Chapter 1. An Overview by Harold S. Ginsberg". The Adenoviruses. Springer Science & Business Media. p. 1. ISBN 978-1-4684-7935-5.
  19. ^ Departments of Labor and Health, Education, and Welfare Appropriatons for Department of Health, Education, and Welfare: Hearings Before the Subcommittee of the Committee on Appropriations, House of Representatives, 87th Congress, First Session. 1961. p. 70.
  20. ^ "Dr. Wallace, Given Another Honor—Second in 2 Months—Ricketts Award" (PDF). The NIH Record. XXVI (11): 1 & 8. May 21, 1974.
  21. ^ "Selman A. Waksman Award in Microbiology". National Academy of Sciences.
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