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Vitaliy Khutoryanskiy

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Vitaliy Khutoryanskiy
Born (1975-05-01) May 1, 1975 (age 49)
Alma materAl-Farabi Kazakh National University
EmployerUniversity of Reading
Known forhis research on interpolymer complexes, water-soluble polymers, hydrogels, functionalized nanoparticles and drug delivery
Websitehttps://www.reading.ac.uk/pharmacy/staff/professor-vitaliy-khutoryanskiy

Vitaliy Khutoryanskiy FRSC FAPS is a British and Kazakhstani scientist, a Professor of Formulation Science and a Royal Society Industry Fellow at the University of Reading.[1] His research focuses on polymers, biomaterials, nanomaterials, drug delivery, and pharmaceutical sciences. Khutoryanskiy has published over 200 original research articles, book chapters, and reviews. His publications have attracted > 12000 citations and his current h-index is 54.[2] He received several prestigious awards in recognition for his research in polymers, colloids and drug delivery[3][4] as well as for contributions to research peer-review[5] and mentoring of early career researchers.[6] He holds several honorary professorship titles from different universities.[7][8]

Education and career

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Khutoryanskiy was born and grew up in Almaty, Kazakhstan.[9] He studied at Al-Farabi Kazakh National University, graduating with a BSc in Chemistry in 1996. He earned his MSc in Polymer Chemistry in 1998, and then his PhD in Polymer Chemistry in 2000, both from the same institution. His PhD project was focused on the studies of hydrogen-bonded interpolymer complexes and preparation of hydrophilic films.[10][11] During his PhD studies, he also spent 4 months in the research group of Janusz Rosiak at Łódź University of Technology, Poland,[9] where specialised in radiation chemistry of hydrophilic polymers.[12] He worked as a Lecturer in Polymer Science at Al-Farabi Kazakh National University in 2000-2002. In 2002, he moved to the United Kingdom and joined the research group of Ijeoma Uchegbu at the University of Strathclyde as a postdoctoral research assistant, where worked on the synthesis of chitosan amphiphiles and their studies for drug delivery.[13] In 2004, he moved to the University of Manchester to work as a postdoctoral research assistant of Nicola Tirelli, studying the design of oxidation-responsive nanoparticles.[14] In 2005, Khutoryanskiy was appointed as a Lecturer in Pharmaceutics at newly-established Reading School of Pharmacy, University of Reading. In 2010, he was promoted to Reader (Associate Professor) in Pharmaceutical Materials and in 2014, he became full Professor of Formulation Science.[9][15] In 2023, he became the founding director of the Physicochemical, Ex Vivo and Invertebrate Tests and Analysis Centre (PEVITAC) at the University of Reading.

Research

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Earlier research of Khutoryanskiy was focused on the studies of hydrogen-bonded interpolymer complexes formed by poly(carboxylic acids) and various non-ionic polymers in aqueous and organic solvents. He established the factors affecting the complexation between polymers such as solvent nature, pH and ionic strength of solutions, nature and molecular weight of interacting polymers as well as environmental temperature.[11][16][17] He also researched radiation-mediated grafting of hydrophilic polymers on polyolefin surfaces[18] and complexes formed between linear polymers and hydrogels.[19] His current research broadly focuses on water-soluble polymers, colloids and hydrogels for applications in drug delivery, biomaterials, and various formulations (food technology, health care products and agrochemicals). His group has pioneered several new families of polymers and nanomaterials with enhanced mucoadhesive properties,[20][21][22] they also were the first to develop mucosa-mimetic polymeric hydrogels that can be used in place of animal tissues to study mucoadhesive dosage forms[23][24][25] and demonstrated that nanoparticles decorated with poly(2-oxazolines), poly(2-hydroxyethylacrylate) and poly(N-vinylpyrrolidone) exhibit mucus-penetrating properties similar to PEGylated nanocarriers.[26][27] Research was carried out to evaluate the adhesive and retention properties of various polymer and colloidal compositions in the oral cavity, with the goal of enhancing the taste of dietary supplements[28] and improving the effectiveness of toothpastes.[29] Additionally, the feasibility of using water-soluble polymers to increase the retention of pesticides on agricultural plant surfaces was explored.[30] His other significant research contributions include the new synthesis of thiolated silica nanoparticles,[31] which were subsequently commercialised by PolySciTech;[32] studies of novel ocular penetration enhancers,[33][34] nanoparticles penetration into various biological membranes,[35] formulation of encapsulated probiotic bacteria,[36][37] new method for synthesis of hydrogels,[38] development of new toxicological assays using planaria[39][40] and the use of various poly(2-oxazolines) for preparation of solid drug dispersions[41] and iodophors.[42]

Books

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He edited and co-edited several books[43]

  • Hydrogen-bonded Interpolymer Complexes: Formation, Structure and Applications (edited by V.V. Khutoryanskiy and G.Staikos), World Scientific, 2009
  • Mucoadhesive Materials and Drug Delivery Systems (edited by V.V. Khutoryanskiy), John Wiley & Sons, 2014
  • Temperature-responsive Polymers: Chemistry, Properties, and Applications (edited by V.V. Khutoryanskiy and T.K. Georgiou), John Wiley & Sons, 2018
  • Advances in Mucoadhesive Polymers and Formulations for Transmucosal Drug Delivery (edited by V.V. Khutoryanskiy), MDPI AG, 2020
  • Solid Dispersions for Drug Delivery: Applications and Preparation Methods (edited by V.V. Khutoryanskiy and H. Al-Obaidi), MDPI AG, 2022

Awards and honours

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Professional services

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Khutoryanskiy serves on editorial boards of several international journals, including European Polymer Journal (Elsevier),[55] Journal of Pharmaceutical Sciences (Elsevier),[56] Pharmaceutics (MDPI),[57] Polymers (MDPI),[58] Gels (MDPI)[59] and Reviews and Advanced in Chemistry (Springer).[60] Also he is associate editor and member of journal editorial boards of several national journals in Kazakhstan,[61][62] Uzbekistan[63] and Russia.[64] He guest edited several special issues of Pharmaceutics, Polymers, Gels and Polymers for Advanced Technologies.[65] He is a committee member of Macro Group UK (RSC & SCI Pure and Applied Macromolecular Chemistry Group)[66] and Engineering and Physical Sciences Research Council (EPSRC) peer-review college member.[67] He was involved in organisation of many conferences and symposia as a chair, co-chair and member of organising committees.[68][69][70][71] He is recognised for his outstanding contributions to research peer review and mentoring of early career researchers.[5] Khutoryanskiy has also made substantial contribution to the development of research, training and education of students and researchers at various universities in Kazakhstan.[72][73][74][75][76][77][78][79]

References

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  1. ^ "University of Reading webpage of Prof Vitaliy Khutoryanskiy".
  2. ^ "Scopus preview – Khutoryanskiy, Vitaliy V. – Author details – Scopus". www.scopus.com. Retrieved 2022-09-05.
  3. ^ a b "PHARMACY ACADEMIC AWARDED MEDAL FOR RESEARCH INTO NEW MATERIALS".
  4. ^ a b "Sticky and slippery drug materials award – University of Reading". www.reading.ac.uk. Retrieved 2022-06-11.
  5. ^ a b c "Web of Science". www.webofscience.com. Retrieved 2022-09-04.
  6. ^ a b "Postgraduate research supervisor at Reading 'best in UK'". Reading Chronicle. 31 August 2020. Retrieved 2022-06-11.
  7. ^ a b "'STICKY DRUGS' ACADEMIC RECEIVES HONOUR FROM PRESTIGIOUS RUSSIAN UNIVERSITY".
  8. ^ a b "A FAMOUS BRITISH SCIENTIST WAS AWARDED THE TITLE OF HONORARY PROFESSOR OF BUKETOV UNIVERSITY".
  9. ^ a b c ""Best PhD supervisor in the UK[1]" discusses pharmaceutics, teaching and karate".
  10. ^ Z.S., Nurkeeva; G.A., Mun; V.V., Khutoryanskiy (2001). "Interpolymer complexes of poly(glycol vinyl ethers) and related composite materials". Высокомолекулярные соединения. Серия Б. 43 (5): 925–935. ISSN 2308-1139.
  11. ^ a b Mun, Grigoriy A.; Nurkeeva, Zauresh S.; Khutoryanskiy, Vitaliy V.; Bitekenova, Asem B. (2000). "Effect of copolymer composition on interpolymer complex formation of (co)poly(vinyl ether)s with poly(acrylic acid) in aqueous and organic solutions". Macromolecular Rapid Communications. 21 (7): 381–384. doi:10.1002/(SICI)1521-3927(20000401)21:7<381::AID-MARC381>3.0.CO;2-B.
  12. ^ Khutoryanskiy, Vitaliy V.; Kujawa, Piotr; Nurkeeva, Zauresh S.; Rosiak, Janusz M. (2001-04-01). <1089::aid-macp1089>3.0.co;2-s "Radiation Synthesis of Linear and Crosslinked Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride and Complex Formation with Potassium Hexacyanoferrates (II, III) in Aqueous Solutions". Macromolecular Chemistry and Physics. 202 (7): 1089–1093. doi:10.1002/1521-3935(20010401)202:7<1089::aid-macp1089>3.0.co;2-s. ISSN 1022-1352.
  13. ^ Qu, Xioazhong; Khutoryanskiy, Vitaliy V.; Stewart, Ailsa; Rahman, Samina; Papahadjopoulos-Sternberg, Brigitte; Dufes, Christine; McCarthy, Dave; Wilson, Clive G.; Lyons, Robert; Carter, Katharine C.; Schätzlein, Andreas (2006-12-01). "Carbohydrate-Based Micelle Clusters Which Enhance Hydrophobic Drug Bioavailability by Up to 1 Order of Magnitude". Biomacromolecules. 7 (12): 3452–3459. doi:10.1021/bm0604000. ISSN 1525-7797. PMID 17154474.
  14. ^ Khutoryanskiy, Vitaliy V.; Tirelli, Nicola (2008-01-01). "Oxidation-responsiveness of nanomaterials for targeting inflammatory reactions". Pure and Applied Chemistry. 80 (8): 1703–1718. doi:10.1351/pac200880081703. ISSN 1365-3075. S2CID 55012679.
  15. ^ "Biography of Prof Khutoryanskiy published in relation to his 2022 Innovative Science Award". The Academy of Pharmaceutical Sciences. Retrieved 2023-01-06.
  16. ^ Khutoryanskiy, Vitaliy V.; Dubolazov, Artem V.; Nurkeeva, Zauresh S.; Mun, Grigoriy A. (2004-04-01). "pH Effects in the Complex Formation and Blending of Poly(acrylic acid) with Poly(ethylene oxide)". Langmuir. 20 (9): 3785–3790. doi:10.1021/la049807l. ISSN 0743-7463. PMID 15875416.
  17. ^ Khutoryanskiy, Vitaliy V; Mun, Grigoriy A; Nurkeeva, Zauresh S; Dubolazov, Artem V (September 2004). "pH and salt effects on interpolymer complexation via hydrogen bonding in aqueous solutions". Polymer International. 53 (9): 1382–1387. doi:10.1002/pi.1549. ISSN 0959-8103.
  18. ^ Aal, Al-Sayed Abdel; Khutoryanskiy, Vitaliy V.; Nurkeeva, Zauresh S.; Mun, Grigoriy A. (2002-08-30). "Radiation grafting of vinyl ether of monoethanolamine on polypropylene films for application in waste water treatment". Journal of Materials Chemistry. 12 (9): 2692–2695. doi:10.1039/B202689A. ISSN 1364-5501.
  19. ^ Khutoryanskiy, Vitaliy V.; Nurkeeva, Zauresh S.; Mun, Grigoriy A.; Sergaziyev, Aibek D.; Ryskalieva, Zhanna; Rosiak, Janusz M. (2003-04-01). "Polyelectrolyte complexes of soluble poly-2-[(methacryloyloxy)ethyl]trimethylammonium chloride and its hydrogels with poly(acrylic acid)". European Polymer Journal. 39 (4): 761–766. doi:10.1016/S0014-3057(02)00293-8. ISSN 0014-3057.
  20. ^ "New extra 'sticky' microgel could revolutionise bladder cancer treatment". phys.org. Retrieved 2022-09-04.
  21. ^ Tonglairoum, Prasopchai; Brannigan, Ruairí P.; Opanasopit, Praneet; Khutoryanskiy, Vitaliy V. (2016-10-12). "Maleimide-bearing nanogels as novel mucoadhesive materials for drug delivery". Journal of Materials Chemistry B. 4 (40): 6581–6587. doi:10.1039/C6TB02124G. ISSN 2050-7518. PMID 32263701.
  22. ^ Brotherton, Emma E.; Neal, Thomas J.; Kaldybekov, Daulet B.; Smallridge, Mark J.; Khutoryanskiy, Vitaliy V.; Armes, Steven P. (2022-05-26). "Aldehyde-functional thermoresponsive diblock copolymer worm gels exhibit strong mucoadhesion". Chemical Science. 13 (23): 6888–6898. doi:10.1039/D2SC02074B. ISSN 2041-6539. PMC 9200053. PMID 35774174. S2CID 249114990.
  23. ^ "University of Reading offers alternative to animals in drug tests". phys.org. Retrieved 2022-06-19.
  24. ^ Guarino, Ben (28 August 2015). "Hydrogel Mucus-Mimic Aims to Replace Animals for Gastric Drug Testing". Inverse. Retrieved 2022-09-04.
  25. ^ Newton, Jennifer. "Synthetic stomach membrane to minimise animal tests". Chemistry World. Retrieved 2022-10-20.
  26. ^ Mansfield, Edward D. H.; Sillence, Katy; Hole, Patrick; Williams, Adrian C.; Khutoryanskiy, Vitaliy V. (2015-08-06). "POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers". Nanoscale. 7 (32): 13671–13679. Bibcode:2015Nanos...713671M. doi:10.1039/C5NR03178H. ISSN 2040-3372. PMID 26214263. S2CID 14523682.
  27. ^ Ways, Twana Mohammed M.; Filippov, Sergey K.; Maji, Samarendra; Glassner, Mathias; Cegłowski, Michal; Hoogenboom, Richard; King, Stephen; Lau, Wing Man; Khutoryanskiy, Vitaliy V. (2022-11-15). "Mucus-penetrating nanoparticles based on chitosan grafted with various non-ionic polymers: Synthesis, structural characterisation and diffusion studies". Journal of Colloid and Interface Science. 626: 251–264. Bibcode:2022JCIS..626..251W. doi:10.1016/j.jcis.2022.06.126. hdl:1854/LU-01GMB2BX6RPB3ZQDS6N7YQC2HW. ISSN 0021-9797. PMID 35797869. S2CID 250097398.
  28. ^ Cook, Sarah L.; Methven, Lisa; Parker, Jane K.; Khutoryanskiy, Vitaliy V. (2018-06-01). "Polysaccharide food matrices for controlling the release, retention and perception of flavours". Food Hydrocolloids. 79: 253–261. doi:10.1016/j.foodhyd.2017.12.023. ISSN 0268-005X.
  29. ^ Aspinall, Sam R.; Parker, Jane K.; Khutoryanskiy, Vitaliy V. (2021-12-01). "Role of mucoadhesive polymers in retention of toothpaste in the oral cavity". Colloids and Surfaces B: Biointerfaces. 208: 112104. doi:10.1016/j.colsurfb.2021.112104. ISSN 0927-7765.
  30. ^ Symonds, Brett L.; Thomson, Niall R.; Lindsay, Christopher I.; Khutoryanskiy, Vitaliy V. (2016-06-08). "Rainfastness of Poly(vinyl alcohol) Deposits on Vicia faba Leaf Surfaces: From Laboratory-Scale Washing to Simulated Rain". ACS Applied Materials & Interfaces. 8 (22): 14220–14230. doi:10.1021/acsami.6b01682. ISSN 1944-8244.
  31. ^ Irmukhametova, Galiya S.; Mun, Grigoriy A.; Khutoryanskiy, Vitaliy V. (2011-08-02). "Thiolated Mucoadhesive and PEGylated Nonmucoadhesive Organosilica Nanoparticles from 3-Mercaptopropyltrimethoxysilane". Langmuir. 27 (15): 9551–9556. doi:10.1021/la201385h. ISSN 0743-7463. PMID 21707076.
  32. ^ "PolySciTech® - PolyVivo PEG PLA PLGA and PCL copolymers by catalog number". akinainc.com. Retrieved 2022-06-11.
  33. ^ Morrison, Peter W. J.; Porfiryeva, Natalia N.; Chahal, Sukhmanpreet; Salakhov, Ilgiz A.; Lacourt, Charlène; Semina, Irina I.; Moustafine, Rouslan I.; Khutoryanskiy, Vitaliy V. (2017-10-02). "Crown Ethers: Novel Permeability Enhancers for Ocular Drug Delivery?". Molecular Pharmaceutics. 14 (10): 3528–3538. doi:10.1021/acs.molpharmaceut.7b00556. ISSN 1543-8384. PMID 28825493.
  34. ^ Broadwith2013-04-09T00:00:00+01:00, Phillip. "From molecules to medicines". Chemistry World. Retrieved 2023-01-03.{{cite web}}: CS1 maint: numeric names: authors list (link)
  35. ^ "Nanotechnology could revolutionize treatment of eye conditions". www.nanowerk.com. Retrieved 2022-09-04.
  36. ^ Howes, Laura. "Cutting edge chemistry in 2012". Chemistry World. Retrieved 2022-09-04.
  37. ^ Hughes2012-11-06T00:00:00+00:00, Elinor. "Helping good bacteria reach their target". Chemistry World. Retrieved 2023-01-03.{{cite web}}: CS1 maint: numeric names: authors list (link)
  38. ^ Cook, Joseph P.; Goodall, Glenn W.; Khutoryanskaya, Olga V.; Khutoryanskiy, Vitaliy V. (2012-02-27). "Microwave-Assisted Hydrogel Synthesis: A New Method for Crosslinking Polymers in Aqueous Solutions". Macromolecular Rapid Communications. 33 (4): 332–336. doi:10.1002/marc.201100742. PMID 22252908.
  39. ^ "New Research Shows Skin Treatments Could Be Tested With Flatworms to Avoid Rabbit Skin Testing". SciTechDaily. 2020-10-01. Retrieved 2022-09-04.
  40. ^ "Flatworms proposed as alternative to rabbit skin testing". cosmeticsbusiness.com. Retrieved 2022-10-20.
  41. ^ Shan, Xiaoning; Williams, Adrian C.; Khutoryanskiy, Vitaliy V. (2020-11-30). "Polymer structure and property effects on solid dispersions with haloperidol: Poly(N-vinyl pyrrolidone) and poly(2-oxazolines) studies". International Journal of Pharmaceutics. 590: 119884. doi:10.1016/j.ijpharm.2020.119884. ISSN 0378-5173. PMID 32950665. S2CID 221826541.
  42. ^ Makhayeva, Danelya N.; Filippov, Sergey K.; Yestemes, Sanzhar S.; Irmukhametova, Galiya S.; Khutoryanskiy, Vitaliy V. (2022-02-15). "Polymeric iodophors with poly(2-ethyl-2-oxazoline) and poly(N-vinylpyrrolidone): optical, hydrodynamic, thermodynamic, and antimicrobial properties". European Polymer Journal. 165: 111005. doi:10.1016/j.eurpolymj.2022.111005. ISSN 0014-3057.
  43. ^ "Amazon.co.uk : Khutoryanskiy". www.amazon.co.uk. Retrieved 2022-09-04.
  44. ^ Khutoryanskiy, Vitaliy V.; Kujawa, Piotr; Nurkeeva, Zauresh S.; Rosiak, Janusz M. (2001). "Radiation Synthesis of Linear and Crosslinked Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride and Complex Formation with Potassium Hexacyanoferrates (II, III) in Aqueous Solutions". Macromolecular Chemistry and Physics. 202 (7): 1089–1093. doi:10.1002/1521-3935(20010401)202:7<1089::AID-MACP1089>3.0.CO;2-S. ISSN 1521-3935.
  45. ^ Khutoryanskiy, Vitaliy V.; Cascone, Maria Grazia; Lazzeri, Luigi; Barbani, Nicoletta; Nurkeeva, Zauresh S.; Mun, Grigoriy A.; Bitekenova, Asem B.; Dzhusupbekova, Aizhana B. (2003). "Hydrophilic Films Based on Blends of Poly(acrylic acid) and Poly(2-hydroxyethyl vinyl ether): Thermal, Mechanical, and Morphological Characterization". Macromolecular Bioscience. 3 (2): 117–122. doi:10.1002/mabi.200390017. ISSN 1616-5195.
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  79. ^ "Учёный из Великобритании читает лекции в университете Жубанова — Новости Университета Жубанова". news-ru.arsu.kz. Retrieved 2023-04-06.
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