VPS39

VPS39
Identifiers
Aliases	VPS39, TLP, VAM6, hVam6p, HOPS complex subunit, VPS39 subunit of HOPS complex
External IDs	OMIM: 612188; MGI: 2443189; HomoloGene: 41025; GeneCards: VPS39; OMA:VPS39 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q15.1 Start 42,158,701 bp End 42,208,307 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E5 Start 120,146,942 bp End 120,183,618 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube granulocyte gastric mucosa skin of leg right lobe of thyroid gland skin of abdomen left lobe of thyroid gland anterior pituitary apex of heart right adrenal cortex Top expressed in zygote secondary oocyte primary visual cortex genital tubercle neural layer of retina facial motor nucleus superior frontal gyrus cerebellar cortex motor neuron supraoptic nucleus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 23339 269338 Ensembl ENSG00000166887 ENSMUSG00000027291 UniProt Q96JC1 Q8R5L3 RefSeq (mRNA) NM_001301138 NM_015289 NM_147153 NM_178851 NM_001363053 NM_001363054 RefSeq (protein) NP_001288067 NP_056104 NP_671495 NP_849182 NP_001349982 NP_001349983 Location (UCSC) Chr 15: 42.16 – 42.21 Mb Chr 2: 120.15 – 120.18 Mb PubMed search
Wikidata
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hVamp6/Vps39-like protein is a protein that in humans is encoded by the VPS39 gene.

This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–286. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Felici A, Wurthner JU, Parks WT, et al. (2003). "TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling". EMBO J. 22 (17): 4465–4477. doi:10.1093/emboj/cdg428. PMC 202370. PMID 12941698.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.