User talk:Firefly's luciferase/Archive 1

Archive 1

Help with dermatology-related content

I know you passed before, I am looking for more help at the dermatology task force, particularly with our new Bolognia push 2009!? Perhaps you would you be able to help us? I could send you the login information for the Bolognia push if you are interested? ---kilbad (talk) 03:57, 4 December 2009 (UTC)

Thank you very much for your kind invitation. Currently I do not have the time to be actively involved in a task force. I just jump from flower to flower and improve a little bit here and there whenever I find a little time. Good luck for the task force. --Firefly's luciferase (talk) 04:25, 4 December 2009 (UTC)

Rh blood group system

Thanks for correcting this article. What do you mean by " Initially it was wrongly named Rhesus blood group system"? Do you mean it is often wrongly named Rhesus, or it was first named Rhesus incorrectly ... apers0n (talk) 22:49, 6 December 2009 (UTC)

Yes, the antibodies against antigens of the Rh blood group system have nothing to do with the Rhesus Macaque. It was first thought that the recognized antibody to blood of about 80% of even ABO matching donors (see case report) was the same as then described by Landsteiner and Wiener that was produced by rabbits after infusion of red cells of Rhesus Macaque, which also reacted with about 80% of human red cells. Therefore, it was called anti-Rh (or Rh factor) referring to the Rhesus Macaque (or Macaca mulatta).

Later it was, however, recognized that they were antibodies to different antigens on the red blood cells. The one reacting with ape cells was called anti-LW (see Landsteiner-Wiener antigen system); the anti-Rh (or Rh factor) was recognized to react with an antigen called D of a blood group system with 2 genes, therefore 2 proteins presenting various antigens, of which D, C, c, E and e are the most important ones. This blood group system is officially called Rh blood group system (and not Rhesus blood group system; see ISBT terminology reference table). "Rh positive/negative" or even "Rhesus positive/negative" is so far kept for probably historical reasons and just referring to the most immunizing D antigen of this Rh blood group system. Nevertheless, the other antigens are also clinically important. The cited review gives a good introduction into the topic.

By the way: I did not want to diminish the amazing scientific work that has been done to realize these antibodies (see also the Nobel Prize 1930 to Dr. Landsteiner for ABO). Nor did I want to confuse people. :-) I just tried to untie some of probably not so precise elements in the article. However, there are still certain points in it that need clarification in particular to render it correct but also easy to understand for readers with different backgrounds. I am glad for all positive contributions. Thanks. --Firefly's luciferase (talk) 23:33, 6 December 2009 (UTC)

Fascinating, thanks for the explanation. apers0n (talk) 17:21, 8 December 2009 (UTC)

Yes, it is a fascinating story. I will do some cleanups during the next weeks in the article. --Firefly's luciferase (talk) 23:00, 8 December 2009 (UTC)

COTM

You'd be very welcome. I haven't seen this discussed anywhere recently, so the page itself is probably the best place to start. I'm afraid I'm dealing with some serious personal issues at the moment, but I'll certainly help as much as time allows. Tim Vickers (talk) 04:28, 24 February 2010 (UTC)

Thanks. Tim Vickers (talk) 04:39, 24 February 2010 (UTC)

peer review

You are very welcome - glad to help, Ruhrfisch _><>°^° 04:17, 9 March 2010 (UTC)