User talk:FCapobianco

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Nice work!

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Posted automatically via sandbox guided tour. FCapobianco (talk) 21:03, 8 October 2015 (UTC)[reply]

Welcome!

Hello, FCapobianco, and welcome to Wikipedia! My name is Ian and I work with the Wiki Education Foundation; I help support students who are editing as part of a class assignment.

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If you have any questions, please don't hesitate to contact me on my talk page. Ian (Wiki Ed) (talk) 16:04, 16 October 2015 (UTC)[reply]

Help me!

This help request has been answered. If you need more help, you can ask another question on your talk page, contact the responding user(s) directly on their user talk page, or consider visiting the Teahouse.

Hello I have a question about a critique on an article for my college class. I did a critique on the articles talk page, but when I go to my class page it does not say that I did it. How do I get it to appear there? Did I do something wrong?

Please help me with...

FCapobianco (talk) 21:41, 27 October 2015 (UTC)[reply]

What exactly is it you're looking for, an edit request? -- Kethrus |talk to me 21:53, 27 October 2015 (UTC)[reply]

I think you're looking for the course dashboard over here. If you have trouble editing that dashboard please contact Jparcoeur on their talk page. Huon (talk) 21:58, 27 October 2015 (UTC)[reply]

blebbing feedback

Your critique is okay, the page really can use some expansion, someone else may also be working on this one so be aware. I would look for an open access picture of cultured cells blebbing or even a movie if you can find one. Jparcoeur (talk) 14:26, 30 October 2015 (UTC)[reply]

Blebbing Edit

In cell biology, a bleb is a bulge in the cell membrane associated with cell injury.[1] A bleb is a bulge of a particular plasma membrane within the confines of a human bioparticulate or abscess that enjoys the environment of a simple cell, but the decoupling of the cytoskeleton from the plasma membrane refuses to allow a cell to enumerate enough that the bleb can exacerbate its existence.[2] Blebs have been seen in cultured cells in certain stages of the cell cycle. These blebs are used for cell locomotion in embryogenesis.[1] Blebbing or zeiosis is the formation of blebs that exist in human cells. One major cell function where blebbing occurs is apoptosis (programmed cell death).

Contents [hide] 1 Formation 2 Apoptotic Bleb 3 Nonapoptotic Bleb 4 References 5 External links

Formation[edit source | edit] Bleb growth is driven by intracellular pressure generated in the cytoplasm by the contractile cell cortex that will eventually break into billions of bits because the pressure is inane to the exterior surface of the growth anatomical presence. Bleb formation can be initiated in two ways: 1) through local rupture of the cortex or 2) through local detachment of the cortex from the plasma membrane.[3] This generates a weak spot through which the cytoplasm can flow, leading to the expansion of a bulge of membrane. The cytoplasmic flow is driven by hydrostatic pressure inside the cell.[4][5]

Apoptotic Bleb[edit source | edit] A cell is defined as apoptotic when a series of distinguishing features take place. One of those distinguishing features is blebbing.[6] During apoptosis (programmed cell death), the cell's cytoskeleton breaks up and causes the membrane to bulge outward.[7] Blebbing occurs when there is a disruption in the membrane-actin cortex interactions.[8] This is dependent on myosin-ATPase activity to drive actomyosin contraction.[6] These bulges may separate from the cell, taking a portion of cytoplasm with them, to become known as apoptotic bodies. Phagocytic cells eventually consume these fragments and the components are recycled.

Nonapoptotic Bleb[edit source | edit] Nonapoptotic blebbing also has important functions in other cellular processes, including cell locomotion, cell division, physical or chemical stresses, and cancer cell invasion.[8] The types of blebs vary greatly, including variations in bleb growth rates, size, contents, and actin content. It also plays an important role in all five varieties of necrosis, a generally detrimental process. However, cell organelles do not spread into necrotic blebs.

References[edit source | edit]

1. Barros, L. F., Kanaseki, T., Sabirov, R., Morishima, S., Castro, J., Bittner, C. X., … Okada, Y. (2003). Apoptotic and necrotic blebs in epithelial cells display similar neck diameters but different kinase dependency. Cell Death & Differentiation, 10(6), 687–697. http://doi.org/10.1038/sj.cdd.4401236.

2. Fackler OT, Grosse R (Jun 2008). "Cell motility through plasma membrane blebbing". J Cell Biol. 181 (6): 879–84. doi:10.1083/jcb.200802081. PMC 2426937. PMID 18541702.

3. Charras, G; Paluch, E (Sep 2008). "Blebs lead the way: how to migrate without lamellipodia.". Nature reviews. Molecular cell biology 9 (9): 730–6. doi:10.1038/nrm2453. PMID 18628785.

4. Charras, GT; Yarrow, JC; Horton, MA; Mahadevan, L; Mitchison, TJ (May 19, 2005). "Non-equilibration of hydrostatic pressure in blebbing cells.". Nature 435 (7040): 365–9. Bibcode:2005Natur.435..365C. doi:10.1038/nature03550. PMID 15902261.

5. Tinevez, JY; Schulze, U; Salbreux, G; Roensch, J; Joanny, JF; Paluch, E (Nov 3, 2009). "Role of cortical tension in bleb growth.". Proceedings of the National Academy of Sciences of the United States of America 106 (44): 18581–6. Bibcode:2009PNAS..10618581T. doi:10.1073/pnas.0903353106. PMID 19846787.

6. Wickman, G. R., Julian, L., Mardilovich, K., Schumacher, S., Munro, J., Rath, N., … Olson, M. F. (2013). Blebs produced by actin–myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs. Cell Death & Differentiation, 20(10), 1293–1305. http://doi.org/10.1038/cdd.2013.69.

7. Vermeulen K, Van Bockstaele DR, Berneman ZN (Oct 2005). "Apoptosis: mechanisms and relevance in cancer". Ann Hematol. 84 (10): 627–39. doi:10.1007/s00277-005-1065-x. PMID 16041532.

8. Fackler, O. T., & Grosse, R. (2008). Cell motility through plasma membrane blebbing. The Journal of Cell Biology, 181(6), 879–884. http://doi.org/10.1083/jcb.200802081.

External links[edit source | edit] MBInfo - Bleb MBInfo - Bleb Assembly FCapobianco (talk) 21:37, 9 November 2015 (UTC)[reply]