User talk:Dgary0202

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Hello, Dgary0202, and welcome to Wikipedia! My name is Ian and I work with the Wiki Education Foundation; I help support students who are editing as part of a class assignment.

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If you have any questions, please don't hesitate to contact me on my talk page. Ian (Wiki Ed) (talk) 15:47, 26 January 2018 (UTC)

Topics

My topic will be Proteogenomics

List of Possible topics- Assignment 3

1. Proteogenomics

2. Infrared photodissociation spectroscopy

3. Proton-transfer-reaction mass spectrometry

4. Isobaric labeling

5. Ion-mobility spectrometry–mass spectrometry

Articles list

The list of possible articles to edit is here: Wikipedia talk:Wiki Ed/Louisiana State University/Chemistry 4558 Mass Spectrometry (Spring 2018). Check for possible conflicts. mke sure that your list is on your talk page so that I can leave comments on your choices. --Kkmurray (talk) 18:01, 13 February 2018 (UTC)

Bibliography

1. Nesvizhskii, Alexey (November 2014). "Proteogeonomics: concepts, applications, and computational strategies". nature methods. 11 (11): 1114-1125. doi:10.1038/nmeth.3144.
2. Faulkner, Sam; Dun, Matthew D.; Hondermarck, Hubert (22 January 2015). "Proteogenomics: emergence and promise". Cellular and Molecular Life Sciences. 72 (5): 953–957. doi:10.1007/s00018-015-1837-y.
3. Low, Teck Yew; Heck, Albert JR (February 2016). "Reconciling proteomics with next generation sequencing". Current Opinion in Chemical Biology. 30: 14–20. doi:10.13140/RG.2.1.4711.8808.
4. Saeed, F. (2015). "Big data proteogenomics and high performance computing: Challenges and opportunities". 2015 IEEE Global Conference on Signal and Information Processing (GlobalSIP): 141–145. doi:10.1109/GlobalSIP.2015.7418173.

My Outline and Description

I plan to expand on the introduction, methodology, and applications sections and to create a new section discussing the challenges of proteogeonomics.

Outline: 1.Introduction- The introduction section needs to be expanded Proteonomics assumes that current gene models are correct and that the correct protein sequences can be found using a reference protein sequence data base. This is not always the case as novel proteins sequences can occur through mutations, but this issue can be fixed with the use of genomic data.

• Proteogenomic has applications outside of improving gene annotations
• Proteogeonomics also Incorporates transcrptiomics

2. Mehtodology

• In proteogeonmics, geonomic and transcription information is considered and included in the protein sequence data base, where it can be compared with MS spectra to aid in the identification of peptides
• Peptide classes identified by proteogeonomics
• I will discuss the main two classes of peptides and how proteogenomics and how the customizable protein data base can be used for peptide/protein identification

3. Applications- I will add additional information

• Quantitative proteogeonomics
• Oncology Research- I will briefly explain how genomics was used to study cancer causing mutations and how it was realized that proteins plays a role in cancer as well, leading to proteomic research

4. Challenges- I will add a new section that provides information regarding the different challenges of proteogeonomics

• Miss identifying new peptides due to the large amount of data being analyzed, such errors of false discovery are a concern
• Mass spec issues- volume of data and the amount of time it takes to produce spectra
• Computational issues

Speedy deletion nomination of Proteogeonomics

Hello Dgary0202,

I wanted to let you know that I just tagged Proteogeonomics for deletion, because it appears to duplicate an existing Wikipedia article, Proteogenomics.

If you feel that the article shouldn't be deleted, you can contest this deletion, but please don't remove the speedy deletion tag from the top.

You can leave a note on my talk page if you have questions.

Hzh (talk) 14:32, 11 March 2018 (UTC)

Proteogeonomics

Please note that there is no such thing as proteogeonomics, it is merely a mispelling of proteogenomics. Hzh (talk) 14:42, 11 March 2018 (UTC)