User talk:Dalexopoulos

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Again, welcome! --Steven Fruitsmaak (Reply) 17:20, 2 October 2008 (UTC)[reply]

Your edits to urinary tract infection

Dear Dalexopoulos,

I appreciate your additions about UTI treatment using D-mannose. However, I have several concerns:

You are including external links to commercial websites without need (better use internal links)
You are mixing alternative medicine methods with scientific evidence. I agree that reducing E. coli adherence is a very interesting potential target for treating UTI. However, I found no studies that show a direct evidence of D-mannose in humans. I also found no evidence (not even in the N Engl J Med article) that antibiotics predispose to UTIs.

Therefore, I consider your additions fail WP:V, which states: "Editors should provide a reliable source for quotations and for any material that is challenged or likely to be challenged, or the material may be removed."

For example, you stated "D-Mannose is a very successful Natural Supplement used to treat UTI." Where can I verify that it is very successful? How often is it used to treat UTI?

Until you provide more evidence of your claims, I suggest you rewrite your material (pasted below), which is pasted below for your courtesy.

I appreciate that this is difficult for a newcomer. I'm dedicated to providing support if you have any problems with editing or with understanding policies.

kindest regards,

--Steven Fruitsmaak (Reply) 17:26, 2 October 2008 (UTC)[reply]

P.S.: To include references, place the <ref> tags in the text, and they will automatically appear under the References header.

Antibiotics are commonly used to treat UTI's However, it is important to cite that antibiotics given for UTI's , or other infection can actually increase the risk of UTI. Similar to spermidice [1], many antibiotics kill vaginal Lactobacilli. Once the antibiotic treatment ceases, the absence of Lactobacilli leaves the vagina vulnerable to E. Coli (and yeast infection. Once in the vagina, e. Coli can more easily reach the urethra and bladder and begin the infection cycle all over again.

D-Mannose is a very successful Natural Supplement used to treat UTI. Similar to Cranberry Juice, but much faster, D-Mannose is taken orally, and simply, but effectively offers the E. Coli a greater source for D-mannose, the substance that E. Coli adheres to on the walls of the bladder. (see References below)The E. Coli adheres to the larger quantities of D-Mannose and is flushed out of the bladder.

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Re: D-mannose

Dear Dalexopoulos,

thanks for your great understanding and wonderful efforts to clarify my concerns.

As I stated before, the underlying mechanism you are proposing is very logical and acceptable. However, the problem is that most of your reference are not referring to clinical trials in humans. That is why I continue to have problem with statements like "very successful". As far as I can conclude from your references and my own literature search, there is no clinical trial proving the use of D-mannose in humans. However, it seems logical and it is indeed mentioned on alternative medicine sites.

The reference about previous antibiotic use and risk of UIT (Clin Infect Dis 1997) is a great reference, and should definitely be incorporated into a paragraph on D-mannose. You're also referring to cranberry juice: note that the evidence for cranberry juice shows that it can do nothing more than preventing UTIs in only certain populations.

I'll try to write up a paragraph on D-mannose in the UTI article, let me know if this comprise is ok for you.

--Steven Fruitsmaak (Reply) 13:10, 4 October 2008 (UTC)[reply]

Have a look and let me know what you think. --Steven Fruitsmaak (Reply) 13:38, 4 October 2008 (UTC)[reply]

^ {{cite Journal |title=Mannose binding and epithelial cell adherence of Escherichia coli. |journal=Infect Immun. |year=1978 |pages=22:247-254|author=Bar-Shavit Z, Goldman R, Ofek I. Sharon B, Mirelman
^ {{cite Journal |title=Nonoxynol-9: differential antibacterial activity and enhancement of bacterial adherence to baginal epithelial cells. |journal=Infect Dis |year=1991 |pages=164:1216-9|author=Hooton TM, Fennell CL, Clark AM Stamm WE.
^ {{cite Journal |title=A prospecitve study of risk factors for symptomatic urinary tract infection in younr women. |journal=N Engl J Med. |year=1996 |pages=335:468-474|author=Hooten TM, Scholes D, Hughes JP, et al.

[1] {{cite Journal |title=Mannose binding and epithelial cell adherence of Escherichia coli. |journal=Infect Immun. |year=1978 |pages=22:247-254|author=Bar-Shavit Z, Goldman R, Ofek I. Sharon B, Mirelman

[2] {{cite Journal |title=Nonoxynol-9: differential antibacterial activity and enhancement of bacterial adherence to baginal epithelial cells. |journal=Infect Dis |year=1991 |pages=164:1216-9|author=Hooton TM, Fennell CL, Clark AM Stamm WE.

[3] {{cite Journal |title=A prospecitve study of risk factors for symptomatic urinary tract infection in younr women. |journal=N Engl J Med. |year=1996 |pages=335:468-474|author=Hooten TM, Scholes D, Hughes JP, et al.

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