User talk:Chandler.c.ho/sandbox/Terminator (genetics)
"Transcription termination is vital to gene expression and protein functions. Unstoppable transcriptions consume rNTPs and affect gene expression of itself and other genes. Without a termination mechanism in place, additional nucleotide would be translated into peptide. The additional of unwanted peptides ultimately distort protein conformation and its functionalities. Loss of functions of cellular proteins is detrimental to cells. This article does not have an expanded explanation on how rho dependent transcription terminators or rho independent transcription terminators ends transcription. It briefly touched on the topic. Additional pictures should be incorporated to illustrate these two mechanisms. In the case of intrinsic transcription terminators, no description of the terminate sequence was shown. A lot more information on prokaryotic and eukaryotic transcription termination can be appended. Transcription termination is an important aspect of the underlying system of gene expression. Our article should be linked to group B’s eukaryotic transcription in my opinion." -Quoted from Chandler.c.ho on our group page
So I this is the outline I was thinking of
General description
- we need to find/create a good image to post on the page perhaps showing intrinsic termination and/or eukaryotic
termination Contents Prokaryotic termination
- Rho independent
- we can give a brief description with a link to the main article about intrinsic termination
- Rho dependent
- requirement of rho which binds to the rho sequence and dislodges the RNA polymerase. Here's a reference [1]
Eukaryotic termination
- give a brief description including AATAAA sequence that is transcribed and cleaved by a specific endonuclease and then the
addition of polyA with a link to polyadenylation. See Also
References
External Links
- ^ Ciampi, MS. (2006). "Rho-dependent terminators and transcription termination". Microbiology. 152 (Pt 9): 2515–28. doi:10.1099/mic.0.28982-0. PMID 16946247.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: unflagged free DOI (link) - ^ Arimbasseri, AG.; Rijal, K.; Maraia, RJ. "Transcription termination by the eukaryotic RNA polymerase III". Biochim Biophys Acta. 1829 (3–4): 318–30. doi:10.1016/j.bbagrm.2012.10.006. PMID 23099421.
{{cite journal}}: Cite has empty unknown parameter:|month=(help) - ^ Anamika, K.; Gyenis, À.; Tora, L. "How to stop: the mysterious links among RNA polymerase II
occupancy 3' of genes, mRNA 3' processing and termination". Transcription. 4 (1): 7–12. doi:10.4161/trns.22300. PMID 23131668.
{{cite journal}}: Cite has empty unknown parameter:|month=(help); line feed character in|pages=at position 4 (help); line feed character in|title=at position 60 (help) - ^ Santangelo, TJ.; Artsimovitch, I. (2011). "Termination and antitermination: RNA polymerase runs a stop
sign". Nat Rev Microbiol. 9 (5): 319–29. doi:10.1038/nrmicro2560. PMID 21478900.
{{cite journal}}: Unknown parameter|month=ignored (help); line feed character in|title=at position 62 (help) - ^ Hsin, JP.; Manley, JL. (2012). "The RNA polymerase II CTD coordinates transcription and RNA processing". Genes Dev. 26 (19): 2119–37. doi:10.1101/gad.200303.112. PMID 23028141.
{{cite journal}}: Unknown parameter|month=ignored (help)
Oalnafo1 (talk) 02:48, 23 October 2013 (UTC)
Hey chandler.c.ho, the eukaryotic section still needs work which you volunteered to work on. Please let me know if you need help on this section and I will try to help develop it as well. We will be working on the real page now and not on the sandbox page so we can just use this talk page to have constructive discussion. I think I will begin working on a prokaryotic terminator image that can be posted in wikimedia and so we can use them for this page. In addition I will do some further elaboration of the prokaryotic section.64.183.84.198 (talk) 01:22, 10 November 2013 (UTC)