User talk:60.224.102.33

Please look into the correct binding affinity for Mirtazapine at the 5-HT3 receptor. Have pulled the figure from ^[1] ; Mirtazapine is mentioned as having strong antiemetic effects relating to 5-HT3 antagonism, which seems to be incorrect.60.224.102.33 (talk) 06:16, 1 March 2019 (UTC)[reply]

There seems to be conflicting information regarding the receptor activity of Mirtazapine. It is described as a strong antiemetic, similar in action to Ondansetron; yet when looking at the binding affinity data at the above link it is shown to possess very modest binding affinity for the 5-HT3 receptor. Promethazine, a phenothiazine derivative used as for its efficacy as an antiemetic (even at low doses, see "No more than necessary: safety and efficacy of low-dose promethazine." ) also does not show to have a binding affinity for the 5-HT3 receptor, yet like Mirtazapine is effective for relieving nausea.

Ondansetron has a high affinity for the 5-HT3 receptor, which by antagonising, prevents and relieves nausea. Mirtazapine is more comparable to Promethazine and follows a different pharmacological route for attenuating and relieving nausea.

Promethazine is listed as an Antiemetic for its antihistamine properties, have reclassified Mirtazapine under this list due to Mirtazapine's strong antihistamine (H1-antagonist) properties.

Nitrazepam\\

misinformation is so prevalent on this website.

^ http://www.guidetopharmacology.org/GRAC/LigandActivityRangeVisForward?ligandId=7241

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[1] ttp://www.guidetopharmacology.org/GRAC/LigandActivityRangeVisForward?ligandId=7241

[1]