User talk:1093connola

primary source reviewer

This article was well written overall! Good work you guys.

A couple comments:

1. There were a couple grammatical errors and spelling errors that need to be fixed when you edit this page again. 2. I read a couple of your sources and really thought you guys did a good job of picking good sources. There is a lot of information about this topic and I thought you explained elements of confusing information very well and in better terms. In particular I focused on the pharmacology sources. You did a good job of explaining that these channels are becoming more studied and more of a pharmacological target. The source was very well-written. 3. I think that you did a good job of broadly explaining the topic of acid-sensing channels. I think you could add a little more to the introduction paragraph regarding the location of acid-sensing channels and perhaps their relevance on a greater scale (target for drugs/medical use) etc. 4. I think that you guys could switch a couple of your paragraphs in an order that would make more sense. I think switching the channel opening section and the structural paragraphs would be less confusing for the reader. That way the reader can understand the structure first, and then when you are explaining the finger and thumb regions in the channel opening paragraph, it will make more sense. Another thought I had was placing the last four paragprahs in the order of function, location, physiology, and then pharmacology last. AS a reader, that made the most sense to me. 5. OVerall, the information you had for this article was very good and you had great sources. Well done

Secondary Review

Overall, very well written! I especially liked how you linked these pores to diseases that we have heard about. I think that in your introduction you could mention that the two-pore channels play a role in these diseases so the reader gets a very broad idea of the importance of these channels. Also i think you could combine the basic feature paragraph with the structure and domains paragraph, because essentially you are describing the make up of the channel in both. A couple words that would be helpful maybe to describe a little more to the reader such as shaker-like and quasi-tetrameters would make the structure of these pores a little more clear. As mentioned in previous comment, a picture would help a lot.