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C15orf39

C15orf39 is a protein which in humans is encoded by the chromosome 15 open reading frame 39, C15orf39, gene.

Gene

Location

C15orf39 is located on chromosome 15 (15q24.2), spanning 16.53kb starting at 75487985bp and ending at 75504515bp on the plus DNA strand. C15orf39 has three exons, and seven introns.

Message

Known Isoforms

C15orf39 encodes for eight mRNAs, of those, four isoforms code for good proteins.

Protein

General Properties

C15orf39 is 1,047 amino acids long with a molecular mass of 110.6 kDA. C15orf39 is composed of an above average level of proline, and is deficient in isoleucine and asparagine.

Domains and Motifs

Domains of C15orf39 protein.

Tertiary and Quarternary Structure

Predicted tertiary structure for C-terminal end of C15orf39.

Sub-cellular Location

Uncharacterized protein C15orf39 is located in the cytosol of the cell.

Protein Interactions

C15orf39 has been shown to interact with the protein RPLP1, which is an acidic component of the 60s subunit of a ribosome.

Protein Name		Experimental Evidence	Interaction	Function	Paper
HELZ	Helicase with Zinc Finger	Two-Hybrid	Physical	RNA Helicase	Boldt K, 2016
CTBP2	C-Terminal Binding Protein 2	Two-Hybrid	Physical	Transcriptional Repressor /	Huttlin EL, 2017
RPLP1	Large Ribosomal Subunit P1	Two-Hybrid	Physical	Component of 60S ribosomal subunit	Stelzl U, 2005
HSP90B1	Heat Shock Protein 90 Beta 1	Anti-tag immunoprecipitation	Physical	ATP-metabolizing molecular chaperone	Hein MY, 2015
CARD8	Caspase Recruitment Domain 8	Pull-down	Physical	Activation of caspases, inflammation response, NFKB	Huttlin EL, 2017
EIF4ENIF1	Eukaryotic Translation Initiation Factor 4E Nuclear Important Factor 1	Affinity chromatography technology	Physical	Nucleocytoplasmic shuttle protein for translation initiation factor IF4E	Boldt K, 2016
KLHL10	Kelch Like Family Member 10	Affinity chromatography technology	Physical	Adapter that helps mediate protein degradation in spermatogenesis	Huttlin EL, 2017
APP	Amyloid-Beta Precursor Protein	Pull-down	Physical	Bind acetyltransferase complex to promote activation; Alzheimers due to plaque in brain	Olah J, 2011

String: No results.

RNA Level Regulation

miRNA Targeting

There is a predicted miRNA located at 3584-3490bp in the cDNA transcript. Hsa-miR-31-5p has been shown to suppress breast cancer metastases.

Protein Level Regulation

PTM	Location
Phosphorylation	S208, S322, S467, S496, S497, T970
Acetylation	K17
Sumoylation	K17, K57, K154, K358, K569, K975
Sumoylation Interaction	462-466
O-Glycosylation	S497, T970

Homology/Evolution

Paralogs

There are no known paralogs for the human C15orf39 gene.

Orthologs

#	Scientific Name	Common Name	Clade	MYA	Protein Accession #	Length (AA)	% Identity	% Similarity
Ref.	Homo sapiens	Human	Primate	0	NP_056307	1,047	100	100
1	Gorilla gorilla gorilla	Gorilla	Primate	9.06	XP_004056588.1	1,047	99	99
2	Propithecus coquereli	Coquerel’s Sifaka	Primate	74	XP_012496116.1	1,044	81	85
3	Ictidomys tridecemlineatus	Thirteen-lined ground squirrel	Rodentia	90	XP_005316869.1	1,032	80	84
4	Equus caballus	Horse	Perissodactyla	96	XP_023509136.1	1,033	79	82
5	Panthera pardus	Leopard	Carnivore	96	XP_019296960.1	1,015	78	83
6	Delphinapterus leucas	Beluga Whale	Cetacea	96	XP_022435768.1	1,041	78	82
7	Trichechus manatus latirostris	Florida Manatee	Sirenia	105	XP_023585602.1	1,071	75	80
8	Loxodonta africana	African Bush Elephant	Proboscidea	105	XP_003413993.1	1,072	75	80
9	Bos mutus	Domestic Yak	Artiodactyla	96	XP_005891834.1	1,037	74	80
10	Pteropus vampyrus	Large Flying Fox	Chiroptera	96	XP_011380411.1	1,001	74	79
11	Oryctolagus cuniculus	European Rabbit	Lagomorpha	90	XP_017193482.1	999	71	77
12	Condylura cristata	Star-nosed Mole	Insectivora	96	XP_004687638.1	974	71	76
13	Phascolarctos cinereus	Koala	Marsupialia	159	XP_020850196.1	1,381	40	50
14	Omithorhynchus anatinus	Platypus	Monotremata	177	XP_007656779.1	1,119	37	45
15	Lepisosteus oculatus	Spotted Gar	Osteichthyes	435	XP_015199194.1	1,489	31	46
16	Rhincodon typus	Whale Shark	Chondrichthyes	473	XP_020392571.1	1,491	31	45
17	Gekko japonicus	Gekko Japonicus	Reptilia/Squamata	312	XP_015267003.1	1,387	51	61
18	Xenopus laevis	African Clawed Frog	Amphibia	352	XP_018111022.1	1,475	40	52
19	Alligator sinensis	Chinese Alligator	Reptilia/Crocodilia	312	XP_014377946.1	1,409	34	45
20	Nipponia Nippon	Crested Ibis	Aves	312	XP_009468021.1	1,046	32	43
21	Calypte anna	Anna’s Hummingbird	Aves	312	XP_008497951.1	1,256	32	40

Clinical Significance

Disease Association

There is no known link between C15orf39 and any disease phenotypes.