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Coiled-Coil Domain Containing 11, also known as CCDC11 is a protein that is encoded by CCDC11 gene located at chromosome 18 in humans. [1]

Overview

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The CCDC11 gene is located on chromosome 18q21.1 and is made of 39303 BP [2]. The CCDC11 protein is made of 514 amino acids and has a mass of 61835 Da [2]. Its aliases include coiled-coil domain containing protein 11, FLJ32743, OTTHUMP00000163503[2].

Homology

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CCDC has orthologs all the way back to betaproteobacteria which is a class of Proteobacteria[2]. The following table represents a small selection of orthologs found using searches in BLAST and BLAT. This is by no means a comprehensive list; however, it shows the diversity of species that CCDC11 is found.

Species Organism Common Name NCBI Accession Length (AAs) Sequence Identity Sequence Similarity
Homo sapiens Human NP_659457 514 100% 100%
Pan troglodytes Chimpanzee XP_523923.3 514 99% 99%
Callithrix jacchus Marmoset XP_002757278.1 514 92% 95%
Ailuropoda melanoleuca Panda XP_002939158.1 514 83% 91%
Canis familiaris Dog XP_547689.3 514 82% 91%
Bos taurus Cow XP_002697813.1 514 81% 91%
Loxodonata africana Elephant XP_003406348.1 514 80% 91%
Rattus norvegicus Rat XP_001053914.2 514 71% 87%
Mus musculus Mouse NP_083224.2 514 70% 87%
Ornithorhynchus anatinus Platypus XP_001509001.2 465 49% 72%
Monodelphis domestica Oppossum XP_001372850.2 507 47% 70%
Xenopus tropicalis Frog NP_001120281.1 516 39% 65%
Anolis carolinensis Lizard XP_003227331.1 514 37% 62%
Nematostella vectensis Sea anemone XP_001628275.1 440 36% 58%
Branchiostoma floridae Lancelet XP_002609924.1 528 35% 61%
Trichoplax adhaerens Trichoplax XP_002111027.1 514 33% 60%
Danio rerio Zebra fish NP_001038595.2 519 32% 58%
Amphimedon queenslandica Sponge XP_003389146.1 513 31% 60%

Gene neighborhood

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The below image from NCBI shows the gene neighborhood of CCDC11 on chromosome 18. CCDC11 has methyl-CPG binding domain protein 1, MBD1, upstream and myosin VB3, MYO5B, downstream. All CCDC11, MBD1 and MYO5B are oriented negatively. Note the close proximity between MBD1 and CCDC11.

Predicted Post-Translational Modification

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Tools on the ExPASy Proteomics site[3] predict the following post-translational modifications:

Tool Predicted Modification Homo sapiens Mus musculus Bos taurus
YinOYang[4] O-β-GlcNAc T239, S510 T239 T239, S509, T510
NetPhos[5] phosphorylation T8, T17, S43, S53, S56, S57, Y112, T134, S170, S240, S425, S461 T17, S43, S53, S56, S107, Y112, S114, S170, T284, S287, S492 T17, S56, T64, S107, T112, T122, T325, S442, S482, S507

One tool on the ExPASy, iPSORT, showed no signal peptide;however, it indicated CCDC11 to be mitochondrial. Another toold on the ExPASy, SOSUI, indicated the protein to be a soluble protein.


References

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  1. ^ "coiled-coil domain containing 11". Retrieved 25-Feb-2012. {{cite web}}: Check date values in: |accessdate= (help)
  2. ^ a b c d "GeneCards". Retrieved 25-Feb-2012. {{cite web}}: Check date values in: |accessdate= (help)
  3. ^ "ExPASy Proteomics tools". Retrieved 15-Apr-2012. {{cite web}}: Check date values in: |accessdate= (help)
  4. ^ "YinOYang". Retrieved 15-Apr-2012. {{cite web}}: Check date values in: |accessdate= (help)
  5. ^ "NetPhos". Retrieved 15-Apr-2012. {{cite web}}: Check date values in: |accessdate= (help)