User:Yj2907/Demethylating agent
Procaine (PCA) is a demethylating agent considered to be effective in inhibiting the growth of human cancer cells. Several studies have explored and elucidated the effects of procaine on human liver cancer cells and breast cancer cells. Studies have shown that procaine, as an inhibitor of DNA methylation in breast cancer cells, can effectively cause hypomethylation and demethylation of the entire group of breast cancer cell DNA genomes by reducing 5-methylcytosine DNA content.[1] In addition, procaine can effectively restore the gene expression of tumor suppressor genes by demethylating densely hypermethylated CpG-enriched DNA.[1] For human liver cancer cells, procaine is capable of reducing tumor volume by suppressing the cell viability of HLE, HuH7, and HuH6 cells, and it has shown effective inhibition of S/G2/M transition in HLE cells.[2]
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[edit]- ^ a b Villar-Garea, Ana; Fraga, Mario F.; Espada, Jesus; Esteller, Manel (15 August 2003). "Procaine Is a DNA-demethylating Agent with Growth-inhibitory Effects in Human Cancer Cells". Ana Villar-Garea, Mario F. Fraga, Jesus Espada, Manel Esteller; Procaine Is a DNA-demethylating Agent with Growth-inhibitory Effects in Human Cancer Cells1. Cancer Res 15 August 2003; 63 (16): 4984–4989.
- ^ Tada, Motohisa; Imazeki, Fumio; Fukai, Kenichi; Sakamoto, Akemi; Arai, Makoto; Mikata, Rintarou; Tokuhisa, Takeshi; Yokosuka, Osamu (27 July 2007). "Procaine inhibits the proliferation and DNA methylation in human hepatoma cells". Tada, M., Imazeki, F., Fukai, K. et al. Procaine inhibits the proliferation and DNA methylation in human hepatoma cells. Hepatol Int 1, 355–364 (2007).