User:Willpidduck/sandbox

~~To date,~~ Forty-one ion-channel genes and over 1,600 ion-channel mutations have been implicated in the development of epileptic seizure.^[1] These ion channel mutations tend to confer a depolarized resting state to neurons resulting in pathological hyper-excitability.^[2] Equally important in epileptic neuronal hyper-excitability, is the reduction in the activity of inhibitory GABAergic neurons, an effect known as disinhibition^[2]. Disinhibition may result from inhibitory neuron loss, dysregulation of axonal sprouting from the inhibitory neurons in regions of neuronal damage, or abnormal GABAergic signaling within the inhibitory neuron.^[3]

Comments

Thanks for the suggestions. I have a few short notes:

Can you try to use more lay terms? Etiology, for example, can be replaced. You can also modify other sections to make them more understandable to someone who does not have a medical/science background. It is hard to do for this type of content!
You can probably add a few wikilinks to some of the terms used (even ion channel!)
Remove the "To date" part. See WP:Manual_of_Style/Words_to_watch#Relative_time_references
Good work inserting your citations!

JenOttawa (talk) 03:08, 6 November 2018 (UTC)

^ Wei, Feng; Yan, Li-Min; Su, Tao; He, Na; Lin, Zhi-Jian; Wang, Jie; Shi, Yi-Wu; Yi, Yong-Hong; Liao, Wei-Ping (2017-05-09). "Ion Channel Genes and Epilepsy: Functional Alteration, Pathogenic Potential, and Mechanism of Epilepsy". Neuroscience Bulletin. 33 (4): 455–477. doi:10.1007/s12264-017-0134-1. ISSN 1673-7067. PMC 5567559. PMID 28488083.{{cite journal}}: CS1 maint: PMC format (link)
^ ^a ^b Ropper, A (2014). Adams and Victor's Principles of Neurology (10th ed., p. Chapter 16. Epilepsy and Other Seizure Disorders). New York: McGraw-Hill.
^ Liu, Yu-Qiang; Yu, Fang; Liu, Wan-Hong; He, Xiao-Hua; Peng, Bi-Wen (2014-11-05). "Dysfunction of hippocampal interneurons in epilepsy". Neuroscience Bulletin. 30 (6): 985–998. doi:10.1007/s12264-014-1478-4. ISSN 1673-7067. PMC 5562563. PMID 25370443.{{cite journal}}: CS1 maint: PMC format (link)

[1] Wei, Feng; Yan, Li-Min; Su, Tao; He, Na; Lin, Zhi-Jian; Wang, Jie; Shi, Yi-Wu; Yi, Yong-Hong; Liao, Wei-Ping (2017-05-09). "Ion Channel Genes and Epilepsy: Functional Alteration, Pathogenic Potential, and Mechanism of Epilepsy". Neuroscience Bulletin. 33 (4): 455–477. doi:10.1007/s12264-017-0134-1. ISSN 1673-7067. PMC 5567559. PMID 28488083.{{cite journal}}: CS1 maint: PMC format (link)

[:0-2] Ropper, A (2014). Adams and Victor's Principles of Neurology (10th ed., p. Chapter 16. Epilepsy and Other Seizure Disorders). New York: McGraw-Hill.

[3] Liu, Yu-Qiang; Yu, Fang; Liu, Wan-Hong; He, Xiao-Hua; Peng, Bi-Wen (2014-11-05). "Dysfunction of hippocampal interneurons in epilepsy". Neuroscience Bulletin. 30 (6): 985–998. doi:10.1007/s12264-014-1478-4. ISSN 1673-7067. PMC 5562563. PMID 25370443.{{cite journal}}: CS1 maint: PMC format (link)

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