User:W1i2k3i4p5e6d/Guanylate cyclase activator
 | This is the sandbox page where you will draft your initial Wikipedia contribution.
If you're starting a new article, you can develop it here until it's ready to go live. If you're working on improvements to an existing article, copy only one section at a time of the article to this sandbox to work on, and be sure to use an edit summary linking to the article you copied from. Do not copy over the entire article. You can find additional instructions here. Remember to save your work regularly using the "Publish page" button. (It just means 'save'; it will still be in the sandbox.) You can add bold formatting to your additions to differentiate them from existing content. |
Article Draft
[edit]Lead
[edit]Article body
[edit]A guanylate cyclase activator (or "GUCA") is a member of a group of proteins that upregulate guanylate cyclase. GUCA is also known as guanylate cyclase-activating protein (or "GCAP"). Its mutations can be associated with vision defects.[1]
There are several therapeutic drugs that act as GUCAs, including linaclotide and plecanatide, which are guanylate cyclase-C receptor agonists. These drugs increase the secretion of bicarbonate and chloride in the colon and potentially relieve visceral hypersensitivity in IBS-C patients.[2]
References
[edit]- ^ Payne AM, Downes SM, Bessant DA, et al. (1998). "A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1". Hum. Mol. Genet. 7 (2): 273–7. doi:10.1093/hmg/7.2.273. PMID 9425234.
- ^ Saps, Miguel; Miranda, Adrian (2017), Greenwood-Van Meerveld, Beverley (ed.), "Gastrointestinal Pharmacology", Gastrointestinal Pharmacology, vol. 239, Cham: Springer International Publishing, pp. 147–176, doi:10.1007/164_2016_119, ISBN 978-3-319-56359-6, retrieved 2024-04-27