User:UltraStableTetraLoop/TRAF interacting protein

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Role In Mitotic DNA Synthesis (MiDAS)

MiDAS is thought to be a DNA repair mechanism to salvage DNA that has not finished replication during S phase, which may be due to DNA replication stress (RS).^[1] Intrinsic sources of RS include transcription-replication conflicts and “difficult-to-replicate’’ regions.^[1] Extrinsic RS includes exposure to genotoxic agents, depletion of dNTPs, and premature S phase activity which can occur in precancerous cells after oncogene activation.^[1] Some MiDAS pathways require the TRAIP protein to disassemble the replication complex at the stalled replication fork in cases where RS causes the fork to stall during replication.^[1]

^ ^a ^b ^c ^d Bhowmick, Rahul; Hickson, Ian D.; Liu, Ying (2023-10). "Completing genome replication outside of S phase". Molecular Cell. 83 (20): 3596–3607. doi:10.1016/j.molcel.2023.08.023. {{cite journal}}: Check date values in: |date= (help)

[:0-1] Bhowmick, Rahul; Hickson, Ian D.; Liu, Ying (2023-10). "Completing genome replication outside of S phase". Molecular Cell. 83 (20): 3596–3607. doi:10.1016/j.molcel.2023.08.023. {{cite journal}}: Check date values in: |date= (help)

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