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PAROMOMYCIN:

Pharmacokinetics:

Absorption

GI absorption is poor. For IM injection, the absorption is rapid. Paromomycin will reach peak plasma concentration within one following an IM injection. Sundar S, Jha TK, Thakur CP et al. Injectable paromomycin for visceral leishmaniasis in India. N Engl J Med. 2007; 356:2571-81. [PubMed 17582067]. The invitro and invivo activities parallel those of neomycin. http://www.drugbank.ca/drugs/DB01421

Anything that impairs GI motility or any obstructions may increase the absorption of the drug. In addition structural damage such as lesions or ulcerations will tend to increase drug absorption.

Distribution

Accumulation can occur in patients with impaired renal function. citation?

Elimination

Almost 100% of the oral dose is eliminated unchanged via feces; and if there is any absorbed drug, it is will be excreted in urine. Product Information: Humatin(R), paromomycin sulfate capsules. Parke-Davis, Division of Warner-Lambert Company, Morris Plains, NJ, 1999

Drug Interactions:

As any other drug, if you have hypersensitivity to Paromomycin or any of its ingredients, please alert your doctor. Anything that impairs GI motility or any obstructions may increase the absorption of the drug. In addition intestinal structural damages such as lesions or ulcerations will tend to increase drug absorption. Caraco Pharmaceutical Laboratories. Paromomycin sulfate capsules, USP prescribing information. Detroit, MI; 1997 Mar